Diagnosis of an ectopic adrenocorticotropic hormone-secreting bronchial carcinoid by somatostatin receptor scintigraphy

Anaforoğlu, İnan; Ersoy, Kerem; Aşık, Mehmet; Karyağar, Savaş; Algün, Ekrem

doi:10.6061/clinics/2012(08)21

Cited by 6 publications

(5 citation statements)

References 10 publications

(23 reference statements)

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“…Some BC may be too small to be identified by CT scan or show heterogeneity of SSTR expression preventing them from being visualized by SRS (22). It is worth noting that in some cases, the negative somatostatin receptor scintigraphy or 68 Ga-DOTA-peptide PET/CT can be due to downregulated SSTR expression after long-term exposure to hypercortisolism ( 23,24).…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors in ectopic Cushing’s syndrome due to neuroendocrine tumors: a multicenter study

Davì

Cosaro

Piacentini

et al. 2017

European Journal of Endocrinology

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Objective: Evidence is limited regarding outcome of patients with ectopic Cushing's syndrome (ECS) due to neuroendocrine tumors (NETs). Design: We assessed the prognostic factors affecting the survival of patients with NETs and ECS. Methods: Retrospective analysis of clinicopathological features, severity of hormonal syndrome, treatments from a large cohort of patients with NETs and ECS collected from 17 Italian centers. Results: Our series included 110 patients, 58.2% female, with mean (±s.d.) age at diagnosis of 49.5 ± 15.9 years. The main sources of ectopic ACTH were bronchial carcinoids (BC) (40.9%), occult tumors (22.7%) and pancreatic (p)NETs (15.5%). Curative surgery was performed in 56.7% (70.2% of BC, 11% of pNETs). Overall survival was significantly higher in BC compared with pNETs and occult tumors (P = 0.033) and in G1-NETs compared with G2 and G3 (P = 0.007). Negative predictive factors for survival were severity of hypercortisolism (P < 0.02), hypokalemia (P = 0.001), diabetes mellitus (P = 0.0146) and distant metastases (P < 0.001). Improved survival was observed in patients who underwent NET removal (P < 0.001). Adrenalectomy improved short-term survival. Clinical Study

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Section: Discussionmentioning

confidence: 99%

Prognostic factors in ectopic Cushing’s syndrome due to neuroendocrine tumors: a multicenter study

Davì

Cosaro

Piacentini

et al. 2017

European Journal of Endocrinology

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“…63 Functional imaging studies such as PET and somatostatin receptor scintigraphy (SRS) are complementary imaging tools. [68][69][70] Somatostatin receptor scintigraphy might be considered superior to PET in detecting bronchial carcinoids, especially that these tumors specifically are known to have low proliferation index. [69][70]…”

Section: Ectopic Cushing Syndrome Prevalence Presentation and Diagnosismentioning

confidence: 99%

“…[68][69][70] Somatostatin receptor scintigraphy might be considered superior to PET in detecting bronchial carcinoids, especially that these tumors specifically are known to have low proliferation index. [69][70]…”

Section: Ectopic Cushing Syndrome Prevalence Presentation and Diagnosismentioning

confidence: 99%

Endocrine Paraneoplastic Syndromes: A Review

Arabi¹

2015

EMIJ

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This paper provides an overview on the common PNES, their prevalence, diagnosis, prognosis and response to treatment. (Table 1) Methodology of literature searchEligible studies were identified by a search, from year 1920 up till February 2014, in Medline, PUBMED and EMBASE using a refined search strategy with several terms used including "endocrine paraneoplastic syndromes", "ectopic hormones", "humoral hypercalcemia of malignancy", "ectopic parathyroid hormone related peptide", "ectopic ACTH", "ectopic Cushing syndrome", "ectopic

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“…Adrenocorticotropic hormone (ACTH) dependent Cushing syndrome is divided into Cushing disease from pituitary secretion and ectopic ACTH syndrome from an extra-pituitary secretion. Ectopic ACTH production accounts for 10%-20% of the cases of ACTH-dependent Cushing syndrome [ 1 ]. Common sites of paraneoplastic ACTH secretion include small cell lung carcinoma, islet cell tumor, bronchial carcinoid, and pheochromocytoma.…”

Section: Introductionmentioning

confidence: 99%

Elevated Adrenocorticotropic Hormone, Hypercortisolism, and Marked Hypernatremia

Wassel¹,

Umeh²,

Giberson³

et al. 2021

Cureus

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We present a case of refractory hypernatremia in a patient with elevated adrenocorticotropic hormone (ACTH) and hypercortisolism. Cortisol’s effect in tissues results in various outcomes, from maintaining blood pressure to increasing serum glucose levels. In addition, cortisol, cortisone, and aldosterone activate mineralocorticoid receptors with the same affinity; therefore, the activation of mineralocorticoid receptors by elevated cortisol levels leads to increased sodium reabsorption, increased potassium secretion, and metabolic alkalosis. Hypernatremia in our patient was initially refractory to fluid replacement but was eventually corrected with intravenous fluid and desmopressin. Overall, we suggest that hypercortisolism should be considered a differential diagnosis in hypernatremia refractory to fluids replacement.

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Diagnosis of an ectopic adrenocorticotropic hormone-secreting bronchial carcinoid by somatostatin receptor scintigraphy

Cited by 6 publications

References 10 publications

Prognostic factors in ectopic Cushing’s syndrome due to neuroendocrine tumors: a multicenter study

Prognostic factors in ectopic Cushing’s syndrome due to neuroendocrine tumors: a multicenter study

Endocrine Paraneoplastic Syndromes: A Review

Elevated Adrenocorticotropic Hormone, Hypercortisolism, and Marked Hypernatremia

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