An economic evaluation of antihypertensive therapies based on clinical trials

Abstract

OBJECTIVE:Hypertension is a major issue in public health, and the financial costs associated with hypertension continue to increase. Cost-effectiveness studies focusing on antihypertensive drug combinations, however, have been scarce. The cost-effectiveness ratios of the traditional treatment (hydrochlorothiazide and atenolol) and the current treatment (losartan and amlodipine) were evaluated in patients with grade 1 or 2 hypertension (HT1-2). For patients with grade 3 hypertension (HT3), a third drug was added to the treatment combinations: enalapril was added to the traditional treatment, and hydrochlorothiazide was added to the current treatment.METHODS:Hypertension treatment costs were estimated on the basis of the purchase prices of the antihypertensive medications, and effectiveness was measured as the reduction in systolic blood pressure and diastolic blood pressure (in mm Hg) at the end of a 12-month study period.RESULTS:When the purchase price of the brand-name medication was used to calculate the cost, the traditional treatment presented a lower cost-effectiveness ratio [US$/mm Hg] than the current treatment in the HT1-2 group. In the HT3 group, however, there was no difference in cost-effectiveness ratio between the traditional treatment and the current treatment. The cost-effectiveness ratio differences between the treatment regimens maintained the same pattern when the purchase price of the lower-cost medication was used.CONCLUSIONS:We conclude that the traditional treatment is more cost-effective (US$/mm Hg) than the current treatment in the HT1-2 group. There was no difference in cost-effectiveness between the traditional treatment and the current treatment for the HT3 group.

Antihypertensive use, prescription patterns, and cost of medications in a Teaching Hospital in Lagos, Nigeria

“…[13,14] Studies have reported the direct costs in the treatment of hypertension (cost of medication, consultation, laboratory investigations) and indirect costs (increased absenteeism from work, decreased productivity, and disease-related disabilities). [15,16] Management of hypertension is for life and antihypertensive medications are relatively expensive. In a study conducted in a rural community in Ibadan, it found that the economic burden of hypertension treatment was significant and that half of the patients were spending a tenth or more of their income on health care-related Table 2].…”

Clinical and cost-effectiveness analysis of the methods of therapy and prevention of andrological pathologies using drugs based on ozone and nano-biomaterials

“…Дослідженнями даної проблематики займається наука -фармакоекономіка, розвиток якої бере свій початок у 90-х роках минулого століття (Bowling, 1996). На сьогодні фармакоекономічні дослідження стали невід'ємною складовою системи оцінки ефективності новостворених лікарських засобів або раціональності використання коштів, що витрачаються на терапію і профілактику різноманітних захворювань (Yokohama et al, 2007;Tsuji et al, 2012).…”

“…Отримані результати узгоджуються з даними інших дослідників щодо особливостей оцінки ефекту деяких препаратів, вартісна характеристика яких не завжди виступає головним критерієм їхньої рентабельності (Tsuji et al, 2012;Allen et al, 2018;Fleck, 2018).…”