Environmental Enrichment Effect on Oxidative Stress in Hypertensive Rats

Cezar, M. D. M.; Lima, A. R. R.; Pagan, Luana Urbano; Damatto, Ricardo Luiz

doi:10.5935/abc.20190221

Cited by 2 publications

(2 citation statements)

References 10 publications

(8 reference statements)

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“…Previous research has indicated that an enriched environment promotes antioxidant effects on the ventrolateral bulb and kidneys and is a potential factor for reducing mean arterial pressure and oxidative damage in renovascular hypertensive rats. 27 Thus, driving cessation most likely reduced participants' exposure to an enriched environment, which may have had negative health effects and contributed to physical frailty transition. Moreover, driving cessation may lead to life-space constriction and decreased physical activity, which is a component of physical frailty.…”

Section: Discussionmentioning

confidence: 99%

Driving cessation and physical frailty in community‐dwelling older adults: A longitudinal study

Ishii

Doi

Tsutsumimoto

et al. 2021

Geriatrics Gerontology Int

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Physical frailty is a critical health problem that can increase the risk of adverse health outcomes in older adults. Driving cessation has been associated with negative outcomes such as disability. However, the relationship between physical frailty and driving cessation remains unclear. Thus, this study aimed to examine whether driving cessation is associated with physical frailty transition in community-dwelling older adults.Methods: This prospective cohort study was performed in a community setting in Japan. Participants were 2934 older Japanese adults, classified into two groups according to their driving status: a driving group (drivers at baseline who continued driving at a 4-year follow-up) and a driving cessation group (drivers at baseline who ceased driving by 4-year follow-up). We examined the association between physical frailty transition and driving cessation over a 4-year period, using logistic regression analysis before and after imputation.Results: In total, 3.9% of community-dwelling older adults had ceased driving by the 4-year follow-up. Rates for physical frailty transition in the driving and driving cessation groups were 4.6% and 17.1%, respectively (P < 0.001). In fully adjusted logistic regression analysis, when compared with driving, driving cessation independently affected physical frailty transition. The results were similar after multiple imputations.Conclusions: Our findings indicated driving cessation was an independent risk factor associated with physical frailty transition in older adults. As physical frailty in older adults can contribute to negative health outcomes, including increased disability and mortality, preventing frailty has important public health implications.

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Section: Discussionmentioning

confidence: 99%

Driving cessation and physical frailty in community‐dwelling older adults: A longitudinal study

Ishii

Doi

Tsutsumimoto

et al. 2021

Geriatrics Gerontology Int

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“…Moderate-intensity training improves OS while high-intensity training does not reverse OS and muscle damage during aerobic exercises ( 33 – 37 ). Breathing exercises, a moderate-intensity training technique used in pulmonary rehabilitation, have been widely used in clinical practice ( 38 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of breathing exercises on oxidative stress biomarkers in humans: A systematic review and meta-analysis

Wang

Zhang

et al. 2023

Front. Med.

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BackgroundBreathing exercises improve oxidative stress in healthy young adults and patients with diabetes, hypertension, and chronic obstructive pulmonary disease. Furthermore, the mechanism of respiratory intervention is controversial. Therefore, in this meta-analysis, we aimed to systematically evaluate the effects of breathing exercises on oxidative stress biomarkers in humans and provide evidence for the clinical application of breathing exercises.MethodsThe Embase, PubMed, Cochrane Library, Web of Science, CNKI, and WANFANG databases were searched for studies about the effects of breathing exercises on human oxidative stress levels, with no restraints regarding time, race, or language. The experimental group included various breathing exercises, and the outcome index included malondialdehyde, superoxide dismutase, and glutathione, nitric oxide, vitamin C, or total antioxidant capacity levels from a randomized controlled trial. Data were extracted by more than two authors and reviewed by one author.ResultsTen studies were included from five countries. Data from patients with no disease, chronic obstructive pulmonary disease, hypertension, or diabetes were included. Participants who performed breathing exercises had greater changes in the included biomarkers than those who did not, suggesting that these biomarkers can be used to evaluate oxidative stress after respiratory interventions.ConclusionBreathing exercises increased SOD and GSH activities and decreased MDA content.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022337119, identifier CRD42022337119.

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Environmental Enrichment Effect on Oxidative Stress in Hypertensive Rats

Cited by 2 publications

References 10 publications

Driving cessation and physical frailty in community‐dwelling older adults: A longitudinal study

Driving cessation and physical frailty in community‐dwelling older adults: A longitudinal study

Effect of breathing exercises on oxidative stress biomarkers in humans: A systematic review and meta-analysis

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