Exertional Rhabdomyolysis after Military Training Paralleled by Systemic Microvascular Dysfunction and Plasma Cytokine Increase: A Case Report

Pereira, Flavio; Moraes, Roger de; Bavel, Diogo Van; Lorenzo, Andréa Rocha de; Tibiriçá, Eduardo

doi:10.5935/abc.20190165

Cited by 5 publications

(4 citation statements)

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“…Multiple cytokines have not been measured simultaneously in patients with rhabdomyolysis following COVID-19 vaccination, but they have been measured in patients with rhabdomyolysis of other causes. The IL-6 and IL-1β concentrations were increased in a patient with exertional rhabdomyolysis [7], and the IL-6 concentration was increased in a patient with rhabdomyolysis with COVID-19 [8]. The IL-1β concentration did not increase in our patient.…”

Section: Discussioncontrasting

confidence: 42%

“…We measured several cytokines over time in our patient to help to elucidate the pathogenetic mechanism of rhabdomyolysis following COVID-19 mRNA vaccination. Multiple cytokines have not been measured simultaneously in patients with rhabdomyolysis following COVID-19 vaccination, but they have been measured in patients with rhabdomyolysis from other causes [7,8]. We report a rare case of an older woman with muscle weakness that completely resolved once and then developed in other muscles owing to rhabdomyolysis after COVID-19 mRNA vaccination.…”

Section: Introductionmentioning

confidence: 99%

“…There are multiple and diverse causes of rhabdomyolysis [2], including various types of vaccinations [3][4][5][6]. Interleukin (IL)-6 and IL-1β concentrations were reported to be increased in a patient with exertional rhabdomyolysis [7], and the IL-6 concentration was increased in a patient with rhabdomyolysis and coronavirus disease 2019 (COVID-19) [8].…”

Section: Introductionmentioning

confidence: 99%

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Recurring Weakness in Rhabdomyolysis Following Pfizer–BioNTech Coronavirus Disease 2019 mRNA Vaccination

2022

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Rhabdomyolysis is a well-known clinical syndrome of muscle injury. Rhabdomyolysis following coronavirus disease 2019 (COVID-19) vaccination has recently been reported. The patients’ weakness gradually subsided and did not recur. Rhabdomyolysis associated with COVID-19 vaccination has not been assessed by repeated magnetic resonance imaging (MRI) within a short time. We report a rare case of an older woman who developed recurring weakness with rhabdomyolysis after COVID-19 vaccination. A 76-year-old woman presented with myalgia 2 days after receiving a third dose of the COVID-19 vaccine. A physical examination showed weakness of the bilateral iliopsoas muscles. Her creatine kinase concentration was 9816 U/L. MRI showed hyperintensity of multiple limb muscles. She was treated with intravenous normal saline. Her symptoms disappeared within 3 days. However, MRI on day 4 of hospitalization showed exacerbation of the hyperintensity in the left upper limb muscles. On day 5 of hospitalization, weakness of the left supraspinatus and deltoid muscles appeared. MRI on day 8 of hospitalization showed attenuation of the hyperintensity in all muscles. Her weakness and elevated creatine kinase concentration disappeared by day 10. Repeated MRI over a short time may be useful to predict potential weakness and monitor the course of COVID-19 vaccine-induced rhabdomyolysis.

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Section: Discussioncontrasting

confidence: 42%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Recurring Weakness in Rhabdomyolysis Following Pfizer–BioNTech Coronavirus Disease 2019 mRNA Vaccination

2022

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“…No ambiente militar, um estudo de caso avaliou a saúde de três combatentes expostos a exercícios de rastejamento, carregamento de cargas, corrida e desafios mentais, realizados ao longo de dois dias, durante um intenso processo de seleção militar (Atias-Varon et al, 2017 (Pereira et al, 2019).…”

Section: Causas E Fatores De Risco Para Rabdomióliseunclassified

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Editora¹

2021

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os profissionais que o prescrevem. Na pesquisa, os investigadores mostram que, de forma aguda, o exercício é seguro com a carga, volume e intervalos utilizados.Em conclusão, apesar da tendência transdisciplinar em saúde, ainda falta uma verdadeira transferência do conhecimento para a aplicação prática em muitas organizações. Essa revista não tem a pretensão de resolver essa problemática internacional, mas tem a persistência, vontade e investigadores que podem colaborar com os profissionais da saúde nas várias pesquisas que vão sendo efetuadas pelo mundo.É nossa permanente vontade apresentar autores que mostrem os seus trabalhos e que a comunidade científica seja mais valorizada na pesquisa de soluções para uma melhor saúde do indivíduo, dos grupos, da comunidade e da sociedade em geral.

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Analysis of physiological markers and risk factors for the development of rhabdomyolysis in military personnel: a systematic review

Dantas

Nunes

Casimiro-Lopes

et al. 2022

Reviews on Environmental Health

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Objectives To analyze case reports with individual patient data belonging to the Armed Forces submitted to specific physical or military combat training that was affected by rhabdomyolysis and identify factors that influenced the diagnosis and clinical evolution of the syndrome. Content We conducted a systematic review following the PRISMA guidelines and registered on PROSPERO (CRD42021242465). We searched MedLine (via PubMed), Scopus, Cochrane, Lilacs, SciELO, CINAHL, Web of Science, SPORTDiscus, ScienceDirect, and PEDro databases for studies that reported cases of military personnel affected by rhabdomyolysis. Summary and outlook Thirteen studies met the inclusion criteria. Forty-nine individual cases of rhabdomyolysis were analyzed. From them, it was possible to identify several associated factors, which were responsible for developing rhabdomyolysis in military personnel. Thirty military personnel (60%) practiced physical training and 20 (40%) practiced specific military combat training. The creatine kinase (CK) peak ranged from 1,040 to 410,755 U/L, with an average of 44.991 U/L, and 14 (28%) of the cases reported alteration of renal function and four militaries (8%) evolved to death condition. Physical activities performed strenuously and without proper planning conditions such as room temperature, the period without adequate water intake, the amount of equipment used during the activity contributed to the development of rhabdomyolysis in the cases of military personnel analyzed in the present study. Therefore, it is recommended that future studies investigate the relationship between the prevalence of rhabdomyolysis cases and the severity of its consequence when associated with progressive methods of training, hydration control, acclimatization to austere environments, monitoring for the existence of hereditary diseases, and control of the use of supplementary nutritional substances.

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Exertional Rhabdomyolysis after Military Training Paralleled by Systemic Microvascular Dysfunction and Plasma Cytokine Increase: A Case Report

Cited by 5 publications

References 11 publications

Recurring Weakness in Rhabdomyolysis Following Pfizer–BioNTech Coronavirus Disease 2019 mRNA Vaccination

Recurring Weakness in Rhabdomyolysis Following Pfizer–BioNTech Coronavirus Disease 2019 mRNA Vaccination

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Analysis of physiological markers and risk factors for the development of rhabdomyolysis in military personnel: a systematic review

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