Cardiac Effects of Trimetazidine in Diabetic Rats

Mansur, Alfredo José

doi:10.5935/abc.20190012

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…Trimetazidine, as classical prazosin, plays an important role in mediating myocardial metabolism. It can reduce the uptake of FFAs [ 91 ] and strengthen the utilization of glucose by the mitochondria [ 92 ], thereby playing a role in protecting the myocardium [ 93 ]. As a drug of the same class, ranolazine is effective in improving the myocardial metabolism [ 94 ] and in regulating the systemic metabolism in some experiments [ 95 ].…”

Section: Protective Effects Of Lipid-lowering Drugs and The Heart ( ...mentioning

confidence: 99%

Mechanisms of Myocardial Damage Due to Hyperlipidemia: A Review of Recent Studies

Zhang

Wang

et al. 2022

Med Sci Monit

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Myocardial injury and necrosis caused by hyperlipidemia have been investigated by several researchers. Their pathogenesis and molecular basis are different from those of the more common clinical ischemic myocardial injury. Hyperlipidemia leads to peroxide accumulation in the cardiomyocytes, causes lipid overload, decreases the antioxidant capacity of the body, and promotes the inflammatory response. Furthermore, hyperlipidemia causes changes in the structure and function of mitochondria in the cardiomyocytes, which results in their injury and necrosis. Many previous studies have shown that metabolic diseases (eg, obesity and diabetes) and chemical poisoning can lead to hyperlipidemic myocardial injury and necrosis. Moreover, it has been observed that this pathological process can be inhibited by many small molecular substances. In the clinic, myocardial damage can be prevented or reduced by lowering the levels of triglyceride and cholesterol. Myocardial damage can also be regulated via the molecular pathway of myocardial injury caused by hyperlipidemia so that the disease can be treated. The present article reviewed the recent findings reported on the mechanisms of myocardial damage due to hyperlipidemia.

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Section: Protective Effects Of Lipid-lowering Drugs and The Heart ( ...mentioning

confidence: 99%

Mechanisms of Myocardial Damage Due to Hyperlipidemia: A Review of Recent Studies

Zhang

Wang

et al. 2022

Med Sci Monit

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“…The myocardium is a highly energy-consuming and energy-independent morphophysiological structure. In the cell, we separate 2 ways of energy supplying regulation-production and accumulation, in the case of the myocardium, energy accumulation is onerous due to the well-developed myofibrillar apparatus of the cardiomyocytes' cytoplasm [11]. Consequently, only energy generation is possible in the myocardium, and therefore a relatively low content and a high rate of ATP hydrolysis are determined in heart tissue [4].…”

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confidence: 99%

Trimeatazidine: Effective Protector of Heart and Vessels

Avagimyan

Kakturskiy

Gogiashvili

et al. 2022

Medical Science of Armenia

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Триметазидин, соединение пиперазина, широко применяемое в современной клинической практике кардиологами и терапевтами. Данный препарат относится к группе ингибиторов β-окисления свободных жирных кислот. Известно, что при окислении жирных кислот выделяется большое количество энергии, однако данный процесс требует повышенного потребления кислорода. При ишемии происходит сдвиг метаболизма в сторону β-окисления свободных жирных кислот, что связано с еще большим ростом потребности миокарда в кислороде, в то время как метаболизм глюкозы снижается, что приводит к накоплению лактата и, в крайнем случае, к развитию метаболического ацидоза. Таким образом, триметазидин, селективно ингибируя длинноцепочечную 3-кетоацилкофермент А тиолазу (LC 3-KAT), которая является конечным ферментом в пути β-окисления свободных жирных кислот, увеличивает тем самым скорость метаболизма глюкозы.

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Cardiac Effects of Trimetazidine in Diabetic Rats

Cited by 2 publications

References 7 publications

Mechanisms of Myocardial Damage Due to Hyperlipidemia: A Review of Recent Studies

Mechanisms of Myocardial Damage Due to Hyperlipidemia: A Review of Recent Studies

Trimeatazidine: Effective Protector of Heart and Vessels

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