“…There are numerous reports on the estimation of the real risk of the TLE [ 26 , 27 , 28 , 29 ] but none of them considered LRVSO as a predictor of procedure difficulties. Among twenty reports on LRVSO [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ], only three papers analyzed the occurrence of LRVSO before TLE [ 2 , 6 , 14 ], and only two considered the influence of LRVSO on procedure complexity providing at the same time conflicting results. Among 20 reports on LRVSO only two studies were carried out in populations over 200 patients [ 1 , 2 ], 10 in 100–150 participants [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ] and the remaining eight studies in populations consisting of 30–89 patients [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ].…”