Hypertension and Exercise: A Search for Mechanisms

Polegato, Bertha Furlan; Paiva, Sérgio Alberto Rupp de

doi:10.5935/abc.20180146

Cited by 5 publications

(5 citation statements)

References 9 publications

(11 reference statements)

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“…[3][4][5][6][7][8][9] The warning of the upcoming magnificent burden of disease and death worldwide is calling for public health interventions with low healthcare cost.Elevated blood pressure (BP) is modifiable by non-pharmacological interventions such as regular physical activity. [10][11][12] We know from previous epidemiological studies that regular physical activity is associated with lower mortality in the general population. 13,14 Intervention studies in patients with hypertension have granted us the knowledge on how regular physical activity resulted in a significant reduction in BP values.…”

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confidence: 99%

Dose-Response Association Between Level of Physical Activity and Mortality in Normal, Elevated, and High Blood Pressure

et al. 2019

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It has been a challenge to verify the dose of exercise that will produce the maximum health benefits in hypertension. This study aimed to explore the association between level of daily physical activity, all-cause mortality and cardiovascular outcome at different blood pressure levels. A random sample of 18 974 white men and women aged 20 to 98 years were examined in a prospective cardiovascular population study. Self-reported activity level in leisure-time was drawn from the Physical Activity Questionnaire (level I: inactivity; II: light activity; and III: moderate/high-level activity). Blood pressure was defined as normal blood pressure: <120/<80 mm Hg; Prehypertension: 120–139/80–89 mm Hg; Stage I hypertension: 140–159/90–99 mm Hg; Stage II hypertension ≥160/≥100 mm Hg. The mean follow-up time was 23.4±11.7 years. At all levels of blood pressure, higher levels of physical activity were associated with lower all-cause mortality in a dose-response pattern. The pattern remained unchanged after adjustment for following confounders: sex, age, smoking status, education, diabetes mellitus, previous cardiovascular disease, body mass index, and calendar time. Compared with inactivity, following hazard ratios were found for stage I hypertension: light activity, hazard ratio 0.78 (0.72–0.84; P <0.001), moderate/high-level activity, hazard ratio 0.69 (0.63–0.75; P <0.001). At all levels of blood pressure, the risk of cardiovascular events was significantly reduced independent of the level of physical activity. In conclusion, the association between physical activity and all-cause mortality was present in an inverse dose-response pattern at all levels of blood pressure. Physical activity was associated with reduction in cardiovascular events independent of the level of physical activity.

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confidence: 99%

Dose-Response Association Between Level of Physical Activity and Mortality in Normal, Elevated, and High Blood Pressure

et al. 2019

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“…MiRNA expression can also have a role in exercise effects on AH. 32 Relaxing environments (e.g., spa facilities) have been shown to contribute to the modulation of the immune system and inflammation. [33][34][35][36] Inflammation cytokines have been demonstrated to play critical roles in endothelial and smooth muscle cell responses, contributing to endothelial dysfunction and 37 Only 20% of the capillary network of the human body is active at rest, while the remaining 80% of the capillaries are in a reserve state and they start working during physical activities, especially in the mode of relaxation movements.…”

Section: Discussionmentioning

confidence: 99%

Is relaxation exercise therapy effective in the management of patients with severe arterial hypertension?

Lebedeva

Achilov²,

Mavlyanova

et al. 2021

Eur J Transl Myol

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Arterial hypertension (AH) is a burning problem in the world. Antihypertensive pharmacological therapy combined by physical exercises is well-studied in patients with mild and moderate AH. However, studies that have investigated relaxation in patients with severe AH in addition to drug therapy are lacking. Optimization of a comprehensive treatment for patients with severe AH, by using a multicomponent rational antihypertensive pharmacotherapy (PT) with subsequent application of relaxation exercise therapy (RET). The study involved 32 male patients with severe AH. Initially, clinical-instrumental and laboratory examination, blood pressure registration and daily arterial blood pressure monitoring were carried out. Suitable PT was selected for all the patients. 3 months after starting PT the patients were divided in 2 groups. The patients of the 1st group were prescribed RET in addition to PT. The 2nd group of patients continued receiving PT alone. 3 months later, average daily blood pressure (ADBP)-syst and ADBP-diast were compared in both groups. Three months after PT both groups demonstrated a significant decrease in ADBP-syst and ADBP diast, but these indicators remained higher than normal and did not reach the target level. Three months after the inclusion of RET in the comprehensive treatment, the 1st group demonstrated a significant decrease in ADBP (systolic and diastolic), not only in comparison with the initial data, but also with the data observed three months after PT. After 6 months, ADBP-syst and ADBP-diast in the 1st group were significantly lower compared with those of patients in the 2nd group. The inclusion of RET in addition to a multicomponent antihypertensive PT is a promising treatment option for severe AH.

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“…Such treatments, through the use of telecommunications, aim to reduce the side effects of diseases, in addition to improving cost-effectiveness, which has drastically impacted the health system. 3,4 Telemedicine is defined as the use of information and telecommunications technologies to carry out healthcare from a distance, 5 that aims to provide medical care to patients without physical contact, through the use of electronic devices capable of connecting health professionals to patients and to each other, facilitating the enforcement of exams, diagnoses, and remote clinical follow-up. Telemedicine can also provide self-care and self-monitoring regimens for patients at home, which are ideal strategies to facilitate patient management in the absence of face-to-face consultations.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analysis of the effectiveness of remote intervention of patients affected by chronic diseases: A systematic review and meta-analysis

Rezende,

Neto,

Iunes

et al. 2023

The Journal of Medicine Access

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Objectives: The aim of the study was to verify the effectiveness of telemedicine in randomized controlled trials (RCTs) in terms of its influence on physical conditioning, quality of life, and health conditions in adults/elderly people affected by chronic diseases. Design: This was a systematic review and meta-analysis. Methods: The search covered RCTs published from 2011 to 2021 and was conducted using the PubMed, Embase, PEDro, Lilacs, and Cochrane Library databases, on volunteers of both sexes, that were rehabilitated, and/or monitored, and/or evaluated, specifically, via remote care. The extraction, quality of studies, and risk of bias were assessed using the RoB2 (risk of bias) tool, for analysis of the strength of evidence, the GRADE (Grading of Recommendations Assessment, Developing, and Evaluation) method was used, and for the preparation of meta-analysis was used at RevMan 5.4 (Review Manager) was used. Results: The database search identified 3949 potential articles for screening, 13 of which were eligible for the present systematic review, involving 1469 participants with chronic diseases (chronic obstructive pulmonary disease (COPD), asthma, heart failure, diabetes mellitus, and fibromyalgia). Through the meta-analysis, an advantage was identified for the remote intervention on physical conditioning ( p = 0.001), with an estimated effect of 0.29 (0.11, 0.46) and on health conditions ( p = 0.0004), –0.30 (–0.47, –0.14), while for quality of life, no significant difference was identified ( p = 0.90), 0.01 (–0.13, 0.14). Conclusion: Telemedicine has clinical effectiveness for the outcome of physical conditioning and general health conditions in adults with chronic diseases when compared to usual care without face-to-face intervention.

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Hypertension and Exercise: A Search for Mechanisms

Cited by 5 publications

References 9 publications

Dose-Response Association Between Level of Physical Activity and Mortality in Normal, Elevated, and High Blood Pressure

Dose-Response Association Between Level of Physical Activity and Mortality in Normal, Elevated, and High Blood Pressure

Is relaxation exercise therapy effective in the management of patients with severe arterial hypertension?

Analysis of the effectiveness of remote intervention of patients affected by chronic diseases: A systematic review and meta-analysis

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