Adropin and Irisin in Patients with Cardiac Cachexia

Mansur, Alfredo José

doi:10.5935/abc.20180121

Cited by 3 publications

(4 citation statements)

References 4 publications

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“…Serum adropin was negatively correlated with BMI.Concentration of adropin differed between patients with and without cachexia. (18,19,(43)(44)(45) In our study, a decreasing pattern in adropin levels were detected. However, decreases were not significant.…”

Section: Discussionsupporting

confidence: 61%

Morbi̇d Obez Ve Metaboli̇k Sendromlu Çocuklarda Yeni̇ Nesi̇l Enflamatuvar Beli̇rteçleri̇n Değerlendi̇ri̇lmesi̇

Donma¹,

Erselcan²,

Yılmaz³

et al. 2020

Namık Kemal Tıp Dergisi

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Technological advancements, unbalanced nutrition, sedentary life style, are important factors in obesity. Obesity-inflammation relationis beingexamined. In this study, the relationships among new generation inflammatory markers in children with normal body mass index (C) as well as obese (OB), morbid obese (MO) children and those with metabolic syndrome (MetS) were investigated. Materials and Methods: A total of 172 children participated in the study.Group 1 comprised children with normal body-mass index (control group) (C). Obese (OB) children were in Group 2, MO children constituted Group 3 and Group 4 included MO children with MetS. The number of cases were 37, 34, 51 and 50 in groups 1, 2, 3 and 4, respectively. Anthropometric measurements were recorded. Serum spexin, adropin, adipolipin, fibroblast growth factor-21 and fetuin-A levels were determined. Statistical analyses were performed. Result: Spexin and adipolin levels were significantly lower in obese groups than C group (p<0.05). Although adropin and FGF-21 levels did not differ significantly between groups, levels were lower in OB, MO, and MetS groups than C group.There were no significant differences among fetuin-A levels of the groups. Correlations between spexin and adipolin were the highest. These cytokines were negatively correlated with obesity parameters. The correlations between these cytokines were weakened from C group to MetS group. Conclusion: Decreasing spexin and adipolin levels in accordance with increasing obesity degrees and weakening of the correlation between these cytokines in MO group compared to C group may be helpful during the further investigation of obesity.

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Section: Discussionsupporting

confidence: 61%

Morbi̇d Obez Ve Metaboli̇k Sendromlu Çocuklarda Yeni̇ Nesi̇l Enflamatuvar Beli̇rteçleri̇n Değerlendi̇ri̇lmesi̇

Donma¹,

Erselcan²,

Yılmaz³

et al. 2020

Namık Kemal Tıp Dergisi

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“…A low level of circulating irisin was noted in female patients with heart failure with cachexia [69]. By contrast, another study showed a high level of irisin in heart failure with cachexia [70].…”

Section: Irisin In Patients With Heart Failurementioning

confidence: 83%

Role of Irisin in Myocardial Infarction, Heart Failure, and Cardiac Hypertrophy

Wang

2021

Cells

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Irisin is a myokine derived from the cleavage of fibronectin type III domain-containing 5. Irisin regulates mitochondrial energy, glucose metabolism, fatty acid oxidation, and fat browning. Skeletal muscle and cardiomyocytes produce irisin and affect various cardiovascular functions. In the early phase of acute myocardial infarction, an increasing irisin level can reduce endothelial damage by inhibiting inflammation and oxidative stress. By contrast, higher levels of irisin in the later phase of myocardial infarction are associated with more cardiovascular events. During different stages of heart failure, irisin has various influences on mitochondrial dysfunction, oxidative stress, metabolic imbalance, energy expenditure, and heart failure prognosis. Irisin affects blood pressure and controls hypertension through modulating vasodilatation. Moreover, irisin can enhance vasoconstriction via the hypothalamus. Because of these dual effects of irisin on cardiovascular physiology, irisin can be a critical therapeutic target in cardiovascular diseases. This review focuses on the complex functions of irisin in myocardial ischemia, heart failure, and cardiac hypertrophy.

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“…Accumulating evidence supports the role of certain myokines in CVD, with some having the potential to serve as novel biomarkers reflecting disease development (Table 1 , Ref. [ 12 , 13 , 14 , 18 , 19 , 20 , 21 , 24 , 25 , 26 , 34 , 38 , 39 , 40 , 41 , 44 , 46 , 47 , 54 , 56 , 57 , 60 , 62 , 63 , 65 , 66 , 67 , 72 , 73 , 77 , 78 , 81 , 82 , 83 , 87 , 88 , 89 , 90 , 91 , 95 , 96 , 97 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 113 , 115 , 116 , 117 , 119 , 120 , 121 , 122 , 125 , 126 , 128 ]). Myokines are involved in CVD development and can provide new insights into CVD progression and help identify patients at a high risk of poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…Decreased serum irisin levels were reported in patients with sarcopenia, combined with chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) [ 38 ]. Additionally, other studies have shown that HFrEF patients with cardiac cachexia had considerably greater serum adropin and irisin levels than the controls [ 39 ].…”

Section: Irisinmentioning

confidence: 99%

Circulating Myokines as Novel Biomarkers for Cardiovascular Diseases

Lyu,

Guo,

Song

et al. 2024

Rev. Cardiovasc. Med.

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Myokines are a group of cytokines or polypeptides released from skeletal muscle during exercise. Growing evidence suggests that myokines are associated with the development of cardiovascular disease (CVD). Moreover, several myokines in peripheral blood exhibit dynamic changes in different CVD stages. This review summarizes the potential roles of myokines such as myostatin, irisin, brain-derived neurotrophic factor, mitsugumin 53, meteorin-like, and apelin in various CVD, including myocardial infarction, heart failure, atherosclerosis, hypertension, and diabetes. The association of these myokines with biomarkers currently being used in clinical practice is also discussed. Furthermore, the review considers the emerging role of myokines in CVD and addresses the challenges remaining in translating these discoveries into novel clinical biomarkers for CVD.

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Adropin and Irisin in Patients with Cardiac Cachexia

Cited by 3 publications

References 4 publications

Morbi̇d Obez Ve Metaboli̇k Sendromlu Çocuklarda Yeni̇ Nesi̇l Enflamatuvar Beli̇rteçleri̇n Değerlendi̇ri̇lmesi̇

Morbi̇d Obez Ve Metaboli̇k Sendromlu Çocuklarda Yeni̇ Nesi̇l Enflamatuvar Beli̇rteçleri̇n Değerlendi̇ri̇lmesi̇

Role of Irisin in Myocardial Infarction, Heart Failure, and Cardiac Hypertrophy

Circulating Myokines as Novel Biomarkers for Cardiovascular Diseases

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