Cohort of Patients Referred for Brugada Syndrome Investigation in an
            Electrophysiology Service - 19-Year Registry

Neto, Stefan Warpechowski; Leiria, Tiago Luiz Luz; Ley, Laura; Ley, Antonio Lessa Gaudie; Dutra, Luiza Zwan; Pires, Leonardo Martins; Kruse, Marcelo Lapa; Lima, Gustavo Glotz de

doi:10.5935/abc.20180094

Cited by 1 publication

(2 citation statements)

References 21 publications

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“…The mean age and gender was not significantly different between inducible and noninducible patients. In line with our results, no considerable differences were found between inducible and noninducible patients 26 …”

Section: Discussionsupporting

confidence: 92%

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Brugada syndrome in Iran: Insights from a 12‐year longitudinal study

Haghjoo,

Askarinejad,

Madadi

et al. 2024

Cardiovasc electrophysiol

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BackgroundBrugada syndrome (BrS) is characterized by ST‐segment elevation in the right precordial leads, which is not explained by ischemia, electrolyte disturbances, or obvious structural heart disease.AimIn present study, we aim to evaluate presentation, long‐term outcome, genetic findings, and therapeutic interventions in patients with BrS.MethodsBetween September 2001 and June 2022, all consecutive patients with diagnosis of BrS were enrolled in the present study. All patients gave written informed consent for the procedure, and the local ethical committee approved the study.ResultsOf the 76 cases, 79% were proband and 21% were detected during screening after diagnosis of BrS in a family member. Thirty‐three (43%) patients had a typical spontaneous electrocardiogram (ECG) pattern. Thirty percent of the patients were symptomatic; symptomatic patients were more likely to have spontaneous type 1 Brugada ECG pattern in their ECGs (p = .01), longer PR interval (p = .03), and SCN5A mutation (p = .01) than asymptomatic patients. The mean PR interval was considerably longer in men than women (p = .034). SCN5A mutation was found in 9 out of 50 (18%) studied patients. Fifteen percent received appropriate implantable cardioverter‐defibrillator (ICD) therapy and inappropriate ICD interventions were observed in 17%. Presentation with aborted SCD or arrhythmic syncope was the only predictor of adverse outcome in follow‐up (odds ratio: 3.1, 95% confidence interval: 0.7–19.6, p = .001).ConclusionsSymptomatic patients with BrS are more likely to present with spontaneous type 1 Brugada ECG pattern, longer PR interval, and pathogenic mutation in SCN5A gene. Appropriate ICD interventions are more likely in symptomatic patients and those with SCN5A mutation.

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Section: Discussionsupporting

confidence: 92%

“…In line with our results, no considerable differences were found between inducible and noninducible patients. 26…”

Section: Electrophysiology Studymentioning

confidence: 99%