Echocardiographic Assessment of Ventricular Function in Young Patients with Asthma

De-Paula, Camilla Rayane; Magalhães, Giselle Santos; Jentzsch, Nulma Souto; Botelho, Camila Figueredo; Mota, Cleonice de Carvalho Coelho; Murça, Tatiane M.; Ramalho, L.F.C.; Tan, Timothy C.; Capuruço, C.A.; Rodrigues‐Machado, Maria da Glória

doi:10.5935/abc.20180052

Cited by 13 publications

(24 citation statements)

References 33 publications

(48 reference statements)

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“…In the present study, preservation of RV systolic function was confirmed by the use of the 2D STE derived RV strain which did not differ significantly between patients and controls. Preservation of RV systolic function was among the parameters reported by previous studies in asthmatic patients . In contrast to our study, Shedeed reported RV systolic dysfunction in asthmatic patients .…”

Section: Discussioncontrasting

confidence: 99%

“…In our study, PVR and PAP were higher in the patients’ group (compared with the control group). Several studies reported similar results to ours . Additionally, pulmonary VTI was significantly lower in our patients when compared with controls.…”

Section: Discussionsupporting

confidence: 90%

“…In the examined cohort, the diastolic RV dysfunction was noticed since the tricuspid annulus (E′) derived from TDI was significantly lower in asthmatic patients, when compared with the controls. Several studies reported RV diastolic dysfunction in asthmatic patients even before any impairment of RV systolic function.…”

Section: Discussionmentioning

confidence: 99%

“…In favor of this assumption speaks the preserved RV systolic and early diastolic dysfunction discussed earlier among the studied cohort. Several studies reported elevated RV‐MPI in asthmatic patients …”

Section: Discussionmentioning

confidence: 99%

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Evaluation of cardiac function in pediatric patients with mild to moderate bronchial asthma in the era of cardiac strain imaging

Abdelmohsen

Mohamed

Mohsen

et al. 2019

Pediatric Pulmonology

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Objective Bronchial asthma is a common chronic inflammatory airway disease, which may be associated with pulmonary hypertension and cardiac dysfunction. The aim of this study was to evaluate the ability of 2D‐speckle tracking echocardiography (2D‐STE) and tissue doppler imaging (TDI) to detect subtle cardiac dysfunction in pediatric patients with mild to moderate bronchial asthma. Methodology The study included 30 children with mild to moderate bronchial asthma and 27 age‐matched healthy controls. Both groups underwent pulmonary function tests, TDI and 2D‐STE. Myocardial performance index (MPI), S′, E′, A′ velocities, global strain of left ventricle (LV), right ventricle (RV), and right atrium (RA) were measured. Results RV diastolic function was impaired in the patient group, as the tricuspid E′ velocity was significantly lower in the patients when compared with the controls (16 [14‐17] vs 16 [17‐19] cm/s, P = .044), while the RV‐MPI was significantly higher in patients when compared to controls (0.30 [0.27‐0.36] vs 0.30 [0.30‐0.30], P = .001). The global RV longitudinal strain, RA strain, and LV strain did not show significant differences between the test and the control groups. RV systolic parameters and LV systolic and diastolic parameters did not differ significantly between the two groups. Conclusion Pediatric patients with mild to moderate bronchial asthma may have early RV diastolic dysfunction with preserved other cardiac functions.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Evaluation of cardiac function in pediatric patients with mild to moderate bronchial asthma in the era of cardiac strain imaging

Abdelmohsen

Mohamed

Mohsen

et al. 2019

Pediatric Pulmonology

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“…[8][9][10][11][12][13][14] In this population, pulmonary diseases affecting the right heart, especially OSAS and COPD, may cause right heart dysfunction without PHT. De-Paula et al 15 reported similar results in mild-moderate asthma patients. In our study population, TA B L E 3 Evaluation of variables associated with pulmonary artery stiffness there was not any patient with PHT.…”

Section: Pas Is a Relatively New Doppler Echocardiographic Parametermentioning

confidence: 66%

Evaluation of pulmonary artery stiffness in newly diagnosed adult patients with asthma

Baysal

Has

2019

Echocardiography

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Background There are limited studies on the effects of asthma on cardiac function. Right ventricular dysfunction and pulmonary hypertension are cardiovascular complications that may be seen in advanced stages of the disease. Pulmonary artery stiffness (PAS), is a promising, relatively new echocardiographic index that has been reported to increase in right ventricular failure, providing information about pulmonary vascular bed. Aim In this study, we aimed to evaluate PAS, a marker of pulmonary artery elasticity, in adult‐onset asthma. Methods Ninety‐nine nonsmokers who had a new asthma diagnosis between the ages of 18 and 65 years and 97 healthy controls with similar age and sex distribution were included in the study. PAS was calculated by dividing the maximal frequency shift of pulmonary flow (MFS) in pulmonary acceleration time (PAT). Results Clinical and demographic characteristics of both groups were similar (P ˃ 0.05). PAS values were higher in the asthma group than in the control group (25.2 ± 4.5 vs 22.4 ± 4.1, P ˂0.001). TAPSE was lower in the case group (24.9 ± 2.0 vs 25.5 ± 2.1, P = 0.043), while RV MPI was higher (0.36 ± 0.07 vs 0.32 ± 0.06, P ˂0.001). In the multivariate linear regression analysis, RV MPI, RV Em, and TAPSE variables were independent predictors of PAS. Conclusion In our study, PAS values were higher in patients with newly diagnosed adult asthma and we found a significant weak correlation between PAS values and subclinical right ventricular dysfunction.

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Levels of physical activity in children and adolescents with asthma: A systematic review and meta‐analysis

Vasconcello‐Castillo

Torres‐Castro

Sepúlveda-Cáceres

et al. 2021

Pediatric Pulmonology

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Background: In children and adolescents with asthma, the disease may reduce the perceived capability to participate in physical activity (PA) contributing to an increase in the sedentary lifestyle. The literature is unclear as to whether children and adolescents with asthma differ their PA levels from their healthy peers.Objective: Our objective was to describe the different methods and instruments used to measure PA and to compare the PA levels of children and adolescents with asthma with those of their healthy peers.Study Design: We conducted a systematic review of five databases. We included studies that compared the PA measured by objective and subjective instruments in children and adolescents with asthma versus controls. Two independent reviewers analyzed the studies, extracted the data, and assessed the quality of evidence.Results: Of the 5966 reports returned by the initial search, 28 articles reporting on 3184 patients were included in the data synthesis. A forest plot showed that both groups had similar values of moderate to vigorous PA (MVPA; mean difference, −0.05 h/day; 95% confidence interval [CI], −0.11-0.01; p = .13), sedentary time (mean difference 0.00 h/day; 95% CI, −0.22-0.23 h/day; p = .99) and steps/day (mean difference 354 steps/day; 95% CI, −563-1270 steps/day; p = .45). Conclusion:Children and adolescents with asthma have similar MVPA, steps/day, and sedentary time compared to the controls. The main instruments used were questionnaires and accelerometers.

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Echocardiographic Assessment of Ventricular Function in Young Patients with Asthma

Cited by 13 publications

References 33 publications

Evaluation of cardiac function in pediatric patients with mild to moderate bronchial asthma in the era of cardiac strain imaging

Evaluation of cardiac function in pediatric patients with mild to moderate bronchial asthma in the era of cardiac strain imaging

Evaluation of pulmonary artery stiffness in newly diagnosed adult patients with asthma

Levels of physical activity in children and adolescents with asthma: A systematic review and meta‐analysis

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