What is the Role of Two-Dimensional Speckle Tracking Echocardiography in the Diagnosis and Management of Anthracycline-Induced Cardiotoxicity?

Costa, Isabela Bispo Santos da Silva; Hajjar, Ludhmila Abrahão

doi:10.5935/abc.20180047

Cited by 3 publications

(2 citation statements)

References 10 publications

(11 reference statements)

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“…By 2026, data from the USA suggest that 20.3 million people will survive cancer [2,3]. The injuries caused to the cardiovascular system fall within a spectrum and might affect all cardiovascular structures, with manifestations ranging from asymptomatic disease to cardiovascular death [4]. Therefore, a structured programme aimed at caring for these patients has the potential to evaluate cancer patients with safety and quality during different phases of therapy.…”

Section: Introductionmentioning

confidence: 99%

Brazilian cardio-oncology: the 10-year experience of the Instituto do Cancer do Estado de Sao Paulo

Costa

Bittar

Fonseca

et al. 2020

BMC Cardiovasc Disord

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Background In recent years, the field of cardio-oncology has grown worldwide, bringing benefits to cancer patients in terms of survival and quality of life. This study reports the experience of a pioneer cardio-oncology programme at University Cancer Hospital in Brazil over a period of 10 years, describing the clinical profile of patients and the clinical outcomes. Methods A retrospective study was conducted on a cohort of patients treated at the cardio-oncology programme from April 2009 to February 2019. We analysed the characteristics of patients and outcomes, including mortality, according to the type of clinical indication for outpatient care (general cardiology, perioperative evaluation and follow-up and treatment cardiotoxicity). Results From a total of 26,435 medical consultations, we obtained the data of 4535 individuals among the medical care outpatients. When we analysed the clinical characteristics of patients considering the clinical indication - general cardiology, perioperative evaluation and cardiotoxicity outpatient clinics, differences were observed with respect to age (59 [48–66], 66 [58–74] and 69 [62–76], p < 0.001), diabetes (67 [15%], 635 [22.6%] and 379 [29.8%]; p < 0.001), hypertension (196 [43.8%], 1649 [58.7%] and 890 [70.1%], p < 0.001) and dyslipidaemia (87 [19.7%), 735 [26.2%] and 459 [36.2%], p < 0.001). A similar overall mortality rate was observed in the groups (47.5% vs. 45.7% vs. 44.9% [p = 0.650]). Conclusion The number of oncologic patients in the Cardio-Oncology Programme has grown in the last decade. A well-structured cardio-oncology programme is the key to achieving the true essence of this area, namely, ongoing care for cancer patients throughout the disease treatment process, optimizing their cardiovascular status to ensure they can receive the best therapy against cancer.

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Section: Introductionmentioning

confidence: 99%

Brazilian cardio-oncology: the 10-year experience of the Instituto do Cancer do Estado de Sao Paulo

Costa

Bittar

Fonseca

et al. 2020

BMC Cardiovasc Disord

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“…Na população pediátrica, principalmente nos tumores hematológicos em que, altas de doses de AC são esperadas, o uso do dexrazoxano já foi amplamente avaliado em vários estudos(Macedo, 2017).Devido à importância da cardiotoxicidade associada a essas medicações, observa-se que a detecção subclínica dos danos cardíacos, identificada por meio da liberação de biomarcadores como a troponina e o BNP, pode representar uma oportunidade de prevenção da injúria cardiovascular propriamente dita, propiciando tratamento precoce e seguimento individualizado mais adequado. Faz-se relevante a investigação de problemas cardíacos primários, para o seguimento a longo prazo, pois como já visto uma das complicações pode ser a insuficiência cardíaca, carditoxicidade aguda apresentando-se como vasoespasmo coronariano e infarto agudo do miocárdio(Costa; Hajjar, 2018; Mainu et al, 2018).Enfatiza-se o reconhecimento oportuno da disfunção cardíaca nos pacientes. De maneira geral, os efeitos colaterais cardiovasculares observados são arritmias e distúrbios de condução, insuficiência cardíaca (HF), síndromes coronárias agudas, miocardite e pericardite.…”

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TOXICIDADE CARDIOLÓGICA POR ANTRACICLINAS APÓS TRATAMENTO DE LEUCEMIA AGUDA EM CRIANÇAS: revisão integrativa

Costa,

Izane Luisa Xavier Carvalho Andrade,

Maria Belquiane Carvalho Pereira

et al. 2024

Braz. J. Implantol. Health Sci.

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O presente estudo visa discutir as evidências científicas sobre a cardiotoxicidade em crianças após tratamento de Leucemia Linfóide Aguda por antraciclinas. Estudo do tipo revisão integrativa da literatura, associado ao acrônimo PICo e estruturado com os descritores: Cardiotoxicidade, Antraciclinas, Leucemia-Linfoma Linfoblástico de Células Precursoras, no recorte temporal de 2017 a 2022, sendo desenvolvido por meio das bases de dados: Literatura Latino-americana e do Caribe em Ciências da Saúde (LILACS), Medical Literature Analysis and Retrieval System Online (MEDLINE), e Scientific Electronic Library Online (SciELO). O emprego das antraciclinas e seus derivados têm elevado a taxa de sobrevida dos pacientes oncológicos pediátricos. A cardiotoxicidade está descrita como um dos efeitos colaterais mais comuns nessa população, no entanto as pesquisas desenvolvidas demonstram que a modificação dos protocolos terapêuticos buscam reduzir os eventos cardiovasculares indesejáveis.

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Evaluation of Cardiac Function before and after PAD Regimen in Patients with Multiple Myeloma by Three-Dimensional Speckle Tracking Imaging

Chen

Yan

Fan

et al. 2022

Journal of Healthcare Engineering

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In this manuscript, we have evaluated numerous changes of cardiac function in patients with multiple myeloma before and after PAD chemotherapy with 3D speck tracking imaging (3D-STI). For this purpose, 39 patients with multiple myeloma, from July 2019 to December 2020, who received the PAD regimen (bortezomib + doxorubicin liposome + dexamethasone, a course of 12 days) were selected as subjects. A comparison of two-dimensional conventional echocardiographic parameters before and after chemotherapy and 3D-STI related parameters was carried out. After 6 cycles of chemotherapy, the levels of TAPSE, RVFAC, and LVEF were significantly lower than those before chemotherapy ( P < 0.05 ). There was no significant difference in the results of left and right ventricle two-dimensional conventional echocardiography before chemotherapy and 2 or 4 cycles after chemotherapy ( P > 0.05 ). There were significant differences in the levels of RVGCS, RVGLS, RVGRS, LVGLS, and LVGRS before and after chemotherapy ( P < 0.05 ). Specifically, RVGCS: after 6 cycles of chemotherapy < after 4 cycles of chemotherapy < before chemotherapy; RVGLS: after 6 cycles of chemotherapy < after 4 cycles of chemotherapy < after 2 cycles of chemotherapy < before chemotherapy; RVGRS: after 6 cycles of chemotherapy < after 4 cycles of chemotherapy < before chemotherapy; LVGLS: after 6 cycles of chemotherapy < after 4 cycles of chemotherapy < before chemotherapy; and LVGRS: after 6 cycles of chemotherapy < before chemotherapy. The results of Pearson correlation analysis showed that the dose of doxorubicin was negatively correlated with RVGCS, RVGLS, RVGRS, and LVGLS, but not with TAPSE, RVFAC, LVEF, and LVGRS. 3D-STI is helpful for early detection of the changes of left and right ventricular myocardial function after PAD chemotherapy in patients with multiple myeloma. And the early screening value of the RVGLS parameter is higher.

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What is the Role of Two-Dimensional Speckle Tracking Echocardiography in the Diagnosis and Management of Anthracycline-Induced Cardiotoxicity?

Cited by 3 publications

References 10 publications

Brazilian cardio-oncology: the 10-year experience of the Instituto do Cancer do Estado de Sao Paulo

Brazilian cardio-oncology: the 10-year experience of the Instituto do Cancer do Estado de Sao Paulo

TOXICIDADE CARDIOLÓGICA POR ANTRACICLINAS APÓS TRATAMENTO DE LEUCEMIA AGUDA EM CRIANÇAS: revisão integrativa

Evaluation of Cardiac Function before and after PAD Regimen in Patients with Multiple Myeloma by Three-Dimensional Speckle Tracking Imaging

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