Protective Effect of Ischemic Preconditioning on Myocardium Against Remote Tissue Injury Following Transient Focal Cerebral Ischemia in Diabetic Rats

Kumaş, Meltem; Altıntaş, Özge; Karataş, Ersin; Koçyiğit, Abdürrahim

doi:10.5935/abc.20170164

Cited by 7 publications

(7 citation statements)

References 40 publications

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“…Soon after, it was found that the brief and complete interruptions of blood supply to a particular vascular territory provide benefits to other vascular territories to a certain extent (26)(27)(28)(29). Since then, the heart protection effect of RIC has been repeatedly confirmed in various animal models (30)(31)(32)(33)(34)(35)(36). Furthermore, several clinical studies have also shown the beneficial effects of RIC on heart injuries, such as ST-segment elevation myocardial infarction (37,38), and heart failure after primary percutaneous coronary intervention (39).…”

Section: Rationale For the Present Studymentioning

confidence: 99%

Effect of Remote Ischemic Conditioning in Patients With Takotsubo Syndrome After Acute Stroke: Study Protocol for a Randomized Controlled Trial

Wang

et al. 2020

Front. Neurol.

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Introduction: Takotsubo syndrome (TTS) is an acute heart failure syndrome which is preceded by a variety of emotional or physical triggers, with central nervous system conditions being an important trigger. Remote ischemic conditioning (RIC) is a promising interventional treatment based on the probability that both TTS and acute coronary syndrome may respond similarly to interventions. The heart protection effect of RIC has been repeatedly confirmed in animal models and observational clinical trials; however, it has never been studied in patients with TTS after acute stroke in randomized clinical trials with a higher level of evidence. The present study will be a proof-of-concept study to determine whether RIC can reduce cardiac injury and eventually improve the heart function and clinical outcomes of TTS patients after acute stroke.Methods and Analysis: A single-center, outcome-assessor-blinded, randomized controlled trial (RCT) will be conducted to evaluate the effect of RIC in TTS patients after acute stroke. Major eligibility criteria include TTS patients diagnosed with acute stroke, which can be confirmed on computed tomography or magnetic resonance imaging; patients aged 18-75 years; patients admitted to a hospital within 48 h after the onset of acute stroke; and patients diagnosed with Takotsubo cardiomyopathy with an InterTAK diagnostic score ≥50. A total of 60 eligible patients will be randomly allocated into either the RIC or the control group. The primary endpoint is a composite of death from any cause and major adverse cardiac and cerebrovascular events during the in-hospital period and at the 1-and 6-month follow-up.Ethics and dissemination: This study has been approved by the Medical Ethics Committee of Xuanwu Hospital, Capital Medical University ([2017] 072). The study findings will be presented at international conferences and published in a peer-reviewed journal.Trial registration: This study has been prospectively registered in the Chinese Clinical Trial Registry on September 10, 2018 (ChiCTR1800018290).

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Section: Rationale For the Present Studymentioning

confidence: 99%

Effect of Remote Ischemic Conditioning in Patients With Takotsubo Syndrome After Acute Stroke: Study Protocol for a Randomized Controlled Trial

Wang

et al. 2020

Front. Neurol.

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“…The levels of Bcl-2, Bax and caspase-3 in cardiac tissue extract were examined using a Western blot, as described by Kumas et al 32 . In this study, the primary antibodies such as Rabbit anti-Bcl-2 (1:400, Santa Cruz, USA), Rabbit anti-Bax (1:400, Santa Cruz, USA), Rabbit anti-caspase-3 (1:400) and rabbit anti-$-actin (control) (1:400, Santa Cruz, USA) were used.…”

Section: Western Blot Techniquementioning

confidence: 99%

Celastrol Improves Isoproterenol-Induced Heart Failure by Reducing Inflammation, Apoptosis and Oxidative Stress

Lian¹,

Liu²,

Wang³

et al. 2023

International J. of Pharmacology

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Background and Objective: Celastrol is a pentacyclic triterpenoid with a long history of therapeutic potential. Unfortunately, their prime mechanism for myocardial infarction was unknown. Therefore, the current study has investigated celastrolʼs efficiency and its cardioprotective role in isoproterenol-induced heart injury. Materials and Methods: The animals have been separated into 4 groups (n = 6). The test group was pretreated with celastrol on the 7th day at the same time as isoproterenol-induced heart damage on the 6th-7th days. The biochemical parameters were determined in serum and heart tissue homogenates. Results: Celastrol significantly decreased the myocardial infarction markers concentration in serum and increased the antioxidant concentration in isoproterenol-induced heart tissue. In addition to this, celastrol also regulates the membrane-bound as well as lysosome enzymes located in the heart tissue. Furthermore, the elevation of pro-inflammatory cytokines and NF-kB mRNA was lessened by celastrol administration. Celastrol also reduced isoproterenol-induced programmed cell death, by altering the Bcl-2, Bax and caspase-3 levels in cardiac tissue. Conclusion: Current findings suggested that administering celastrol may help to reduce cardiac damage in myocardial infarction by reducing inflammation, apoptosis and oxidative stress.

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“…Histologic data confirming this come from experimental and necropsy studies (2). Ischemic preconditioning/postconditioning (129) emerged as a valuable method to use endogenous rescue mechanisms to decrease myocardial damage by ischemia/reperfusion injury (130,131). Preconditioning has the advantage of having two phases, an early phase that occurs immediately and a late phase after 48-72 h after (132,133).…”

Section: Ischemic Preconditioning/post-conditioningmentioning

confidence: 99%

Getting an Early Start in Understanding Perinatal Asphyxia Impact on the Cardiovascular System

et al. 2020

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Perinatal asphyxia (PA) is a burdening pathology with high short-term mortality and severe long-term consequences. Its incidence, reaching as high as 10 cases per 1000 live births in the less developed countries, prompts the need for better awareness and prevention of cases at risk, together with management by easily applicable protocols. PA acts first and foremost on the nervous tissue, but also on the heart, by hypoxia and subsequent ischemia-reperfusion injury. Myocardial development at birth is still incomplete and cannot adequately respond to this aggression. Cardiac dysfunction, including low ventricular output, bradycardia, and pulmonary hypertension, complicates the already compromised circulatory status of the newborn with PA. Multiorgan and especially cardiovascular failure seem to play a crucial role in the secondary phase of hypoxic-ischemic encephalopathy (HIE) and its high mortality rate. Hypothermia is an acceptable solution for HIE, but there is a fragile equilibrium between therapeutic gain and cardiovascular instability. A profound understanding of the underlying mechanisms of the nervous and cardiovascular systems and a close collaboration between the bench and bedside specialists in these domains is compulsory. More resources need to be directed toward the prevention of PA and the consecutive decrease of cardiovascular dysfunction. Not much can be done in case of an unexpected acute event that produces PA, where recognition and prompt delivery are the key factors for a positive clinical result. However, the situation is different for high-risk pregnancies or circumstances that make the fetus more vulnerable to asphyxia. Improving the outcome in these cases is possible through careful monitoring, identifying the high-risk pregnancies, and the implementation of novel prenatal strategies. Also, apart from adequately supporting the heart through the acute episode, there is a need for protocols for long-term cardiovascular follow-up. This will increase our recognition of any lasting myocardial damage and will enhance our perspective on the real impact of PA. The goal of this article is to review data on the cardiovascular consequences of PA, in the context of an immature cardiovascular system, discuss the potential contribution of cardiovascular impairment on short and long-term outcomes, and propose further directions of research in this field.

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Protective Effect of Ischemic Preconditioning on Myocardium Against Remote Tissue Injury Following Transient Focal Cerebral Ischemia in Diabetic Rats

Cited by 7 publications

References 40 publications

Effect of Remote Ischemic Conditioning in Patients With Takotsubo Syndrome After Acute Stroke: Study Protocol for a Randomized Controlled Trial

Effect of Remote Ischemic Conditioning in Patients With Takotsubo Syndrome After Acute Stroke: Study Protocol for a Randomized Controlled Trial

Celastrol Improves Isoproterenol-Induced Heart Failure by Reducing Inflammation, Apoptosis and Oxidative Stress

Getting an Early Start in Understanding Perinatal Asphyxia Impact on the Cardiovascular System

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