Electrocardiographic Findings in Brazilian Adults without Heart Disease: ELSA-Brasil

Filho, Marcelo; Brant, Luísa Campos Caldeira; Padilha-da-Silva, José Luiz; Foppa, Murilo; Lotufo, Paulo A; Mill, José Geraldo; Vasconcelo-Silva, Paulo R.; Almeida, Maria da Conceição Chagas de; Barreto, Sandhi Maria; Ribeiro, Antônio Luiz Pinho

doi:10.5935/abc.20170146

Cited by 7 publications

(3 citation statements)

References 19 publications

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“…In a recent systematic review and meta-analysis published in 2018, involving 6763 subjects and 6189 controls, Reimers et al [9] reported their mean heart rate to be 72.4 beats per minute and 72.3 beats per minute respectively. These figures are close to that reported in the current study as well as that reported by Kostis et al It is important to note, however, that gender differences in heart rate [10] as well as racial differences in electrocardiographic parameters [11] have been highlighted by previous researchers. Also, racial differences in electrocardiographic abnormalities has been reported [12].…”

Section: Discussionsupporting

confidence: 93%

The Relationship Between Resting Heart Rate and Age in Adult Nigerians

Chime¹,

Okenwa²,

Oti³

2020

AJIM

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Background: Resting heart rate is related to cardiovascular mortality as well as to all-cause mortality. It is therefore important to know whether resting heart rate changes with age in adults. The aim of this study was to determine the relationship between heart rate and age in adult Nigerians. Methods: It was a retrospective study on adult Nigerians attending a University Teaching Hospital in Nigeria. All the needed data were retrieved from the medical records. Heart rate was calculated from the electrocardiogram and correlated with age. Results: There were 99 cases aged between 20 and 54 years and comprised of 60 males and 39 females. The mean heart rate was 73.40±13.16 beats/minute. Across the various decades, the mean heart rate in beats per minute was 73.46±10.70 in the third decade, 75.52±12.16 in the fourth decade, 72.38±13.91 in the fifth decade, and 71.60±18.77 in the sixth decade of life (p=0.770). Heart rate correlated negatively and weakly with age (r=-0.034, p=0.736). There were more cases of sinus bradycardia than sinus tachycardia, but the proportion of cases with heart rate outside 60 beats per minute to 100 beats per minute was small. Conclusion: This study showed that resting heart rate did not change with age in young adult and middle-aged Nigerians who had no clinical evidence of heart disease. A greater proportion of them were in normal sinus rhythm.

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Section: Discussionsupporting

confidence: 93%

The Relationship Between Resting Heart Rate and Age in Adult Nigerians

Chime¹,

Okenwa²,

Oti³

2020

AJIM

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“…Heart rate and all QTc interval had a higher mean and SD in males than females. Pinto Filho et al [ 44 ] in a large Brazilian population showed that mean of P duration, PR interval, QRS duration were higher in their male subjects which were in contrast to our results but in case the mean of P axis was in a line with our study. Moreover, the median of P duration, PR interval, P axis in the aforementioned study was higher than ours.…”

Section: Discussioncontrasting

confidence: 85%

“…Moreover, the median of P duration, PR interval, P axis in the aforementioned study was higher than ours. The increasing trends of P duration, PR interval, QRS duration, P axis, and QTc intervals with increasing age were almost similar to other populations such as Brazilian [ 44 ], Netherlands [ 45 ], Indians [ 46 ], and Chinese [ 47 ].…”

Section: Discussionsupporting

confidence: 75%

The best QT correction formula in a non-hospitalized population: the Fasa PERSIAN cohort study

Yazdanpanah

Naghizadeh

Sayyadipoor

et al. 2022

BMC Cardiovasc Disord

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Background QT interval as an indicator of ventricular repolarization is a clinically important parameter on an electrocardiogram (ECG). QT prolongation predisposes individuals to different ventricular arrhythmias and sudden cardiac death. The current study aimed to identify the best heart rate corrected QT interval for a non-hospitalized Iranian population based on cardiovascular mortality. Methods Using Fasa PERSIAN cohort study data, this study enrolled 7071 subjects aged 35–70 years. Corrected QT intervals (QTc) were calculated by the QT interval measured by Cardiax® software from ECGs and 6 different correction formulas (Bazett, Fridericia, Dmitrienko, Framingham, Hodges, and Rautaharju). Mortality status was checked using an annual telephone-based follow-up and a minimum 3-year follow-up for each participant. Bland–Altman, QTc/RR regression, sensitivity analysis, and Cox regression were performed in IBM SPSS Statistics v23 to find the best QT. Also, for calculating the upper and lower limits of normal of different QT correction formulas, 3952 healthy subjects were selected. Results In this study, 56.4% of participants were female, and the mean age was 48.60 ± 9.35 years. Age, heart rate in females, and QT interval in males were significantly higher. The smallest slopes of QTc/RR analysis were related to Fridericia in males and Rautaharju followed by Fridericia in females. Thus, Fridericia’s formula was identified as the best mathematical formula and Bazett’s as the worst in males. In the sensitivity analysis, however, Bazett’s formula had the highest sensitivity (23.07%) among all others in cardiac mortality. Also, in the Cox regression analysis, Bazett’s formula was better than Fridericia’s and was identified as the best significant cardiac mortality predictor (Hazard ratio: 4.31, 95% CI 1.73–10.74, p value = 0.002). Conclusion Fridericia was the best correction formula based on mathematical methods. Bazett’s formula despite its poorest performance in mathematical methods, was the best one for cardiac mortality prediction. Practically, it is suggested that physicians use QTcB for a better evaluation of cardiac mortality risk. However, in population-based studies, QTcFri might be the one to be used by researchers.

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Association of hypertension and insulin resistance in individuals free of diabetes in the ELSA-Brasil cohort

Castro

Brant

Diniz

et al. 2023

Sci Rep

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Insulin resistance (IR) is defined as the subnormal response to insulin action on its target tissues. Studies suggest that IR may increase the risk of hypertension, but the results are inconsistent and it is not known whether such an effect is independent of overweight/obesity. We aimed to evaluate the association between IR and the incidence of prehypertension and hypertension in the Brazilian population and whether this association is independent of overweight/obesity. In 4717 participants of the Brazilian Longitudinal Study of Adult’s Health (ELSA-Brasil), free of diabetes and cardiovascular disease at baseline (2008–2010), we investigated the incidence of prehypertension and hypertension after a mean follow-up of 3.8 ± 0.5 years. Insulin resistance at baseline was assessed by the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) index, defined if above the 75th percentile. The risk of IR-associated prehypertension/hypertension was estimated by multinomial logistic regression after adjustment for confounding factors. Secondary analysis were stratified by body mass index. The mean (SD) age of participants was 48 (8) years, 67% were women. The 75th percentile of HOMA-IR at baseline was 2.85. The presence of IR increased the chance of developing prehypertension by 51% (95% CI 1.28–1.79) and hypertension by 150% (95% CI 1.48–4.23). In individuals with BMI < 25 kg/m2, the presence of IR remained associated with the incidence of prehypertension (OR 1.41; 95% CI 1.01–1.98) and hypertension (OR 3.15; 95% CI 1.27–7.81). In conclusion, our results suggest that IR is a risk factor for hypertension, regardless of the presence of overweight or obesity.

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Electrocardiographic Findings in Brazilian Adults without Heart Disease: ELSA-Brasil

Cited by 7 publications

References 19 publications

The Relationship Between Resting Heart Rate and Age in Adult Nigerians

The Relationship Between Resting Heart Rate and Age in Adult Nigerians

The best QT correction formula in a non-hospitalized population: the Fasa PERSIAN cohort study

Association of hypertension and insulin resistance in individuals free of diabetes in the ELSA-Brasil cohort

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