Persistent Depressive Symptoms are Independent Predictors of Low-Grade Inflammation
            Onset Among Healthy Individuals

Franco, Frederico Souzalima Caldoncelli; Laurinavicius, Antonio Gabriele; Lotufo, Paulo A; Conceição, Raquel; Morita, Fernando; Katz, Marcelo; Wajngarten, Maurı́cio; Carvalho, José A.M.; Bosworth, Hayden B.; Santos, Raul D.

doi:10.5935/abc.20170080

Cited by 6 publications

(9 citation statements)

References 30 publications

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“…After adjusting for age, sex, metabolic syndrome, BMI, levels of physical activity, smoking, presence of hepatic steatosis, and waist circumference, it was confirmed the association of depressive symptoms and low-grade inflammation. New cases of inflammation were associated with depressive symptoms (OR = 1.76; 95% CI = 1.03-3.02, p = 0.04) [100].…”

Section: Cohort Studiesmentioning

confidence: 95%

“…A cohort study selected 1508 young individuals who were evaluated regarding the incidence of low-grade inflammation (i.e., CRP < 3 mg/L at baseline) and the depressive state using the Beck Depression Inventory (BDI) [100]. The authors found that the incidence of low-grade inflammation was more frequent in patients with depressive symptoms than among healthy controls (OR = 2.05; 95% CI = 1.31-3.21, p < 0.001).…”

Section: Cohort Studiesmentioning

confidence: 99%

“…Based on our judgment, 40 studies were rated as "good" studies [16,45,46,48,49,[51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66]68,[71][72][73]75,76,78,81,83,[88][89][90][92][93][94][96][97][98]100] and 16 as "satisfactory" studies [47,50,67,69,70,74,77,79,80,82,[84]…”

Section: Quality Assessmentmentioning

confidence: 99%

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C-Reactive Protein as a Biomarker for Major Depressive Disorder?

Orsolini

Pompili

Valenta

et al. 2022

IJMS

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The etiopathogenesis of depression is not entirely understood. Several studies have investigated the role of inflammation in major depressive disorder. The present work aims to review the literature on the association between C-Reactive Protein (CRP) and depression. A systematic review was performed for the topics of ‘CRP’ and ‘depression’ using the PubMed database from inception to December 2021. Fifty-six studies were identified and included in the review. Evidence suggested the presence of dysregulation in the inflammation system in individuals with depression. In most studies, higher blood CRP levels were associated with greater symptom severity, a specific pattern of depressive symptoms, and a worse response to treatment. Moreover, about one-third of depressed patients showed a low-grade inflammatory state, suggesting the presence of a different major depressive disorder (MDD) subgroup with a distinct etiopathogenesis, clinical course, treatment response, and prognosis, which could benefit from monitoring of CRP levels and might potentially respond to anti-inflammatory treatments. This work provides robust evidence about the potential role of CRP and its blood levels in depressive disorders. These findings can be relevant to developing new therapeutic strategies and better understanding if CRP may be considered a valuable biomarker for depression.

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Section: Cohort Studiesmentioning

confidence: 95%

Section: Cohort Studiesmentioning

confidence: 99%

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C-Reactive Protein as a Biomarker for Major Depressive Disorder?

Orsolini

Pompili

Valenta

et al. 2022

IJMS

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“…This relationship is quite common in other studies on depression in which the initial severity of depressive symptoms was a strong predictor of depressive symptomatology. [23][24][25][26] Depressive symptoms in general seem to be the main predictor of depressive disorders and broad psychiatric and somatic symptomatology. A similar situation has been replicated in the present study -depressive symptoms, despite their origin, foreshadowed MDD in patients treated for hepatitis C. Moreover, the diagnosis of depression during treatment depended solely on the initial severity of depressive symptoms.…”

Section: Discussionmentioning

confidence: 99%

Biological and psychological components of depression in patients receiving IFN-alpha therapy for hepatitis C

Małyszczak¹,

Inglot²,

Frydecka³

et al. 2019

Adv Clin Exp Med

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Background. Depressive symptoms are frequent side effects of interferon α therapy (IFN-α). Both biological and psychological processes may occur concomitantly during hepatitis C treatment.Objectives. This study was carried out to determine the impact of biological (immune response) and psychological factors on formation of depressive symptoms and major depressive disorder (MDD) during hepatitis C treatment. Material and methods.A total of 99 patients receiving pegylated IFN-α and ribavirin for chronic C type hepatitis participated in the prospective cohort study. Symptoms of depression were assessed with the Montgomery-Åsberg Depression Rating Scale (MADRS) during treatment and 24 weeks after treatment. Neuroticism was measured with the Eysenck Personality Questionnaire -Revised (EPQ-R/N). Diagnosis of MDD was made using the Present State Examination (PSE-10) and DSM-IV-TR criteria. Factor analysis was used to detect factors adding up to total severity of depressive symptoms. Predictors of MDD were investigated using logistic regression analysis.Results. Factor analysis returned 3 factors: 1 st -MADRS scores at weeks 0-12, 2 nd -MADRS and N scores before treatment, 3 rd -MADRS at the 24 th week of treatment and 24 weeks after treatment. The total severity of depressive symptoms consisted of 3 components: personality-related before treatment, IFN-α-related during treatment and dependent on the effect of treatment. Regression analysis showed that a history of psychiatric disorders (OR = 4.8) and MADRS scores before treatment (OR = 1.25) were predictors of MDD, as opposed to level of neuroticism.Conclusions. The severity of depressive symptoms and MDD during the hepatitis C treatment was related to general depressive vulnerability, not to psychological factors related to neuroticism.

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“…Chronic, low-grade inflammation (distinct from acute, life-saving inflammatory responses) has been linked to socioeconomic disadvantage, environmental insults (including the aforementioned lifestyle habits of the westernized diet), excess alcohol, tobacco use, sedentary behavior, exposure to toxins, and psychological stress. Persistent depression and anxiety can predict low-grade inflammation [76,77]. On the other hand, low-grade inflammation (demonstrated most notably by laboratory-induced elevations in inflammatory cytokines, such as IL-6 and TNF-α) can itself promote depressive symptoms, anxiety, fatigue, cognitive disruptions, and pain [78].…”

Section: Biophilosophymentioning

confidence: 99%

Down to Earth: Planetary Health and Biophilosophy in the Symbiocene Epoch

Prescott

Logan

2017

Challenges

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Advances in science have illuminated the role of the "ecological theatre"-the total living environment-in human health. In a rapidly changing epoch known as the anthropocene, microbiome science is identifying functional connections between all life, both seen and unseen. Rather than an easily identifiable era appearing in rock strata, the anthropocene is more of a diagnostic syndrome, a set of signs and symptoms including climate change, gross biodiversity losses, environmental degradation, and an epidemic of non-communicable diseases. The syndrome is intertwined with politics, economics, public policies (or lack thereof), social values, and a global push of calorie-dense, nutrient-poor foods and beverages. The healing of anthropocene syndrome is the grand challenge of humanity. Expanding on the "Mars Can Wait" argument of Geoffrey Goodman, et al., we focus on the urgency with which health promotion must be prioritized here on Earth. We revive Jonas Salk's biophilosophy: a call to action for collaboration between biologists, humanists, and scholars of all stripes. From this perspective, lines of distinction between personal, public, and planetary health are removed. We also describe the symbiocene: the possibility of a new epoch in which mutualism will be considered imperative. If society asks the right questions, a transition to the symbiocene is possible; the "stratigraphical" mark of the new epoch will be found in a repudiation of authoritarianism, and the promotion of empathy, cultural competency, emotional intelligence, and commitment to optimism, tolerance, and the facilitation of the WHO definition of health, i.e., the fulfillment of human potential.

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Persistent Depressive Symptoms are Independent Predictors of Low-Grade Inflammation Onset Among Healthy Individuals

Cited by 6 publications

References 30 publications

C-Reactive Protein as a Biomarker for Major Depressive Disorder?

C-Reactive Protein as a Biomarker for Major Depressive Disorder?

Biological and psychological components of depression in patients receiving IFN-alpha therapy for hepatitis C

Down to Earth: Planetary Health and Biophilosophy in the Symbiocene Epoch

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