The Lack of Clinical Applications Would be the Cause of Low Interest in an Endothelial Dysfunction Classification

Arcêncio, Livia; Évora, Paulo Roberto Barbosa

doi:10.5935/abc.20170019

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…Peripheral skin capillary density is shown to be reduced in patients with premature coronary artery disease, and peripheral microvascular and the blood flow predicts the incidence of cardiovascular events 9 . In addition, early detection of microcirculatory density and reactivity in subclinical cardiovascular disease patients through non‐invasive techniques may help to apply early interventions to prevent cardiovascular events 10 …”

Section: Introductionmentioning

confidence: 99%

Enlargement of opisthenar microcirculatory area predicts impaired heart function in severe acute coronary syndrome patients

et al. 2023

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Background Impaired microcirculation in acute coronary syndrome (ACS) patients manifests inadequate recovery and adverse clinical outcome. Here, we analyzed correlations between peripheral microcirculation and heart function in ACS patients. Methods Opisthenar microvessel area (OMA) were measured with optical coherence tomography angiography (OCTA), cardiac functional indexes (echocardiograph) were assessed 48–72 h after therapeutic interventions. Results Results showed that OMA normalized with heart rate (OMA‐HR) were significantly greater in ACS patients with percutaneous intervention (ACS‐PCI, n = 25, stenosis >80%) compared to those with pharmacological intervention (ACS‐PI, n = 23, stenosis <50%, p = .02). Ejection fraction (EF) and fractional shortening (FS), which were not different between two groups, showed negative correlations with OMA‐HR in ACS‐PCI (EF: r = −0.512, p = .009; FS: r = −0.594, p = .002). Cardiac output (CO) inversely correlated with OMA‐HR in both groups (r = −0.697, p < .0001; r = −0.527, p = .01). Neutrophil to lymphocyte ratio (NLR) on admission was greater in ACS‐PCI group. NLR, which was negatively associated with EF or FS, was positively associated with OMA‐HR in all patients. The area under the curve (AUC) for OMA‐HR was 0.683 (specificity 0.696 and sensitivity 0.72, p = .02). OMA‐HR at >376.5 μm2 predicts reduced FS and CO (p = .002, p = .005, respectively). Summary OMA‐HR predicts inadequate recovery of the heart in severe ACS patients post‐PCI.

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Section: Introductionmentioning

confidence: 99%

Enlargement of opisthenar microcirculatory area predicts impaired heart function in severe acute coronary syndrome patients

et al. 2023

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“…Endothelial dysfunction is an early stage in several vascular diseases and inflammation is involved in the pathological process of organ dysfunction, primarily by motivating endothelial dysfunction. One of the most common results of inflammation is the activation of endothelial cell apoptosis (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

2,3,5,4'‑Tetrahydroxystilbene‑2‑O‑β‑D‑glucoside inhibits septic serum‑induced inflammatory injury via interfering with the ROS‑MAPK‑NF‑κB signaling pathway in pulmonary aortic endothelial cells

Li¹,

Sun²,

Zhou³

et al. 2017

Int J Mol Med

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Sepsis is characterized by injury to the microvasculature and the microvascular endothelial cells, leading to barrier dysfunction. However, the specific role of injury in septic endothelial barrier dysfunction remains to be elucidated. In the present study, it was hypothesized that endothelial cell inflammatory injury is likely required for barrier dysfunction under septic conditions in vitro. 2,3,5,4'‑Tetrahydroxystilbene‑2‑O‑β‑D‑glucoside (TSG), a compound extracted from Chinese herbs, is able to inhibit the inflammatory injury of septic‑serum in endothelial cells. In the present study, cell viability was assayed by CCK‑8 method; mRNA and protein expression was identified by RT‑qPCR, western blot or Elisa, respectively and the production of reactive oxygen species was observed by a fluorescence microscope. The present study indicated that septic serum significantly decreased the cell viability of pulmonary aortic endothelial cells (PAECs) following co‑cultivation for 6 h, which occurred in a time‑dependent manner. TSG notably increased the viability of PAECs in a time‑ and concentration‑dependent manner. Further investigations revealed that septic serum increased the secretion of interleukin (IL)‑1β, IL‑6 and C‑reactive protein in PAECs, whereas pretreatment with TSG significantly decreased the secretion of these inflammatory factors. These data indicated that septic serum increased inflammatory injury to the PAECs, and TSG decreased this injury via the reactive oxygen species‑mitogen‑activated protein kinase‑nuclear factor‑κB signaling pathway.

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“…20 Moreover, microcirculation assessment could be useful to evaluate the chronic effects of cardiovascular drugs, making it attractive not only in research contexts but also in clinical practice.…”

mentioning

confidence: 99%

“…Therefore, the early detection of subclinical cardiovascular disease through the assessment of microcirculatory density and reactivity non-invasive techniques could represent an opportunity for early intervention, and consequently, prevention of cardiovascular events. 20 Moreover, microcirculation assessment could be useful to evaluate the chronic effects of cardiovascular drugs, making it attractive not only in research contexts but also in clinical practice.…”

mentioning

confidence: 99%

Microcirculation and Cardiovascular Diseases

Tibiriçá

Lorenzo

Oliveira

2018

Arquivos Brasileiros De Cardiologia

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The Lack of Clinical Applications Would be the Cause of Low Interest in an Endothelial Dysfunction Classification

Cited by 4 publications

References 19 publications

Enlargement of opisthenar microcirculatory area predicts impaired heart function in severe acute coronary syndrome patients

Enlargement of opisthenar microcirculatory area predicts impaired heart function in severe acute coronary syndrome patients

2,3,5,4'‑Tetrahydroxystilbene‑2‑O‑β‑D‑glucoside inhibits septic serum‑induced inflammatory injury via interfering with the ROS‑MAPK‑NF‑κB signaling pathway in pulmonary aortic endothelial cells

Microcirculation and Cardiovascular Diseases

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