2016
DOI: 10.5935/abc.20160074
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Genetics of Dyslipidemia

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Cited by 27 publications
(25 citation statements)
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References 28 publications
(33 reference statements)
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“…Collectively, data from 70 independent GWAS with sample sizes ranging from ten thousand to several hundred thousand participants have identified associations of traditional lipid levels with 500 single nucleotide polymorphism (SNPs) in 167 loci that explain up to 40% of individual variance in these traditional lipid measures ( Matey-Hernandez et al, 2018 ). This number suggests that LDL, HDL, total cholesterol and triglyceride levels undergo a substantial degree of genetic regulation, but also highlights that much of the lipid variance is still unaccounted for, possibly related to rare variants or environmental factors ( Matey-Hernandez et al, 2018 ; García-Giustiniani and Stein, 2016 ).…”
Section: Introductionmentioning
confidence: 99%
“…Collectively, data from 70 independent GWAS with sample sizes ranging from ten thousand to several hundred thousand participants have identified associations of traditional lipid levels with 500 single nucleotide polymorphism (SNPs) in 167 loci that explain up to 40% of individual variance in these traditional lipid measures ( Matey-Hernandez et al, 2018 ). This number suggests that LDL, HDL, total cholesterol and triglyceride levels undergo a substantial degree of genetic regulation, but also highlights that much of the lipid variance is still unaccounted for, possibly related to rare variants or environmental factors ( Matey-Hernandez et al, 2018 ; García-Giustiniani and Stein, 2016 ).…”
Section: Introductionmentioning
confidence: 99%
“…Investigating genetic associations with LDL-cholesterol levels among sub-Saharan Africans is the focus of this study. LDL-cholesterol levels have a multifactorial aetiology, where environmental factors and variants in many different genes contribute to determining levels of LDLcholesterol [6,7]. We aimed at selecting variants potentially associated with LDL-cholesterol levels.…”
Section: Introductionmentioning
confidence: 99%
“…Nem sempre o fenótipo das dislipidemias mostra-se claro, mesmo com exames complementares, dificultando o diagnóstico precoce e a conduta apropriada. 15 A associação de estatina (alta potência) e ciprofibrato alcançou o objetivo esperado, haja vista os resultados laboratoriais e a cicatrização dos xantomas. Caso não fossem alcançadas as metas de lipoproteína de baixa densidade (LDL-c), a associação de estatina com inibidores de pró-proteína convertase subtilisina/kexina tipo 9 (PCSK9) ou ezetimiba seria uma opção, assim como ômega-3, em conjunto com fibrato, para redução da hipertrigliceridemia.…”
Section: Discussionunclassified