Low-Flow Aortic Stenosis and Reduced Ejection Fraction: New Insights

Rosa, Vitor Emer Egypto; Accorsi, Tarso Augusto Duenhas; Fernandes, João Ricardo Cordeiro; Lopes, Antonio Sérgio de Santis Andrade; Sampaio, Roney Orismar; Tarasoutchi, Flávio

doi:10.5935/abc.20150080

Cited by 2 publications

(3 citation statements)

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“…However, reduced EF has a multifactorial background [ 34 ]. Mentioned earlier aortic stenosis, which is one of the greatest death risk indicators also leads to this condition [ 36 , 37 ]. Therefore, detailed diagnosis is a key tool in identifying reduced EF etiology.…”

Section: Discussionmentioning

confidence: 99%

Impact of chronic kidney disease on long-term outcome of patients with valvular heart defects

Kuźma

Małyszko

Bachórzewska−Gajewska

et al. 2020

Int Urol Nephrol

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Introduction Valvular heart diseases (VHD) are becoming a significant problem in the Polish population. Coexistence of chronic kidney disease (CKD) in patients with VHD increases the risk of death and affects further therapeutic strategy. Aim Analysis impact of CKD on long-term prognosis in patients with VHD. Material and methods The inclusion criteria were met by 1025 patients with moderate and severe VHD. Mean observation time was 2528 ± 1454 days. Results The average age of the studied population was 66.75 (SD = 10.34), male gender was dominant 56% (N = 579). Severe aortic valve stenosis (AVS) occurred in 28.2%, severe mitral valve insufficiency (MVI) in 20%. CKD occurred in 37.1% (N = 380) patients mostly with mitral stenosis (50%, N = 16) and those with severe MVI (44.8%, N = 94). During the observational period, 52.7% (N = 540) deaths were noted. Increased risk of mortality was associated mostly with age (OR: 1.02, 95% CI: 1.00–1.03, p < 0.001), creatinine (OR:1.27, 95% CI: 1.12–1.43, p < 0.001), CKD (OR: 1.30, 95% CI: 1.17–1.44, p < 0.001), reduced ejection fraction (EF) (OR: 0.98, 95% CI: 0.97–0.99, p = 0.01) and coexisting of AVS (OR: 1.19, 95% CI: 1.04–1.35, p = 0.01). Conclusions Mitral valve defects more often than aortic valve defects coexist with chronic kidney disease. Regardless of the stage, chronic kidney disease is an additional factor affecting the prognosis in patients with heart defects. Factors increasing the risk of death were age, creatinine concentration and reduced EF. The monitoring of renal function in patients with VHD should be crucial as well as the implementation of treatment at an early stage.

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