Sudden Cardiac Death and Short QT Syndrome

Pavão, Maria Licia Ribeiro Cury; Ono, Viviane Cristina; Arfelli, Elerson; Simões, Marcus Vinı́cius; Marin-Neto, José Antônio; Schmidt, André

doi:10.5935/abc.20140133

Arquivos Brasileiros De Cardiologia

2014

DOI: 10.5935/abc.20140133

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Sudden Cardiac Death and Short QT Syndrome

Maria Licia Ribeiro Cury Pavão¹,

Viviane Cristina Ono²,

Elerson Arfelli³

et al.

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Cited by 2 publications

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“…The deviation from physiological norms of QTc interval duration is an important unfavorable clinical prognostic sign (Mal`ceva et al, 2014). The reduction in the QTc interval by adrenergic stimulation that alters autonomic balance is likely caused by the release of catecholamines during exertion (Pavão et al, 2014). One of the reasons for the transient form of the syndrome of the shortened QT interval, might be the autonomic nervous system tone disorder.…”

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confidence: 99%

Evaluation of Cardiovascular Dysregulation in Patients After Hemorrhagic Stroke as a Complication of Essential Hypertension

Tkachyshyn

2021

USMYJ

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The aim of the study was to compare blood pressure and electrocardiogram indices, assessed by their daily monitoring, and anamnestic data on mild traumatic brain injury between a group of patients with essential hypertension ≥6 months after a hemorrhagic stroke and a group of patients with essential hypertension without complications. Materials and methods. The total number of examined patients was 198 people, who were divided into 2 groups: the main (n = 94; age – 54,4±8,8 years, M±σ years) and the control (n = 104; age – 53,7±8,9 years) one. Patients in the main group suffered a hemorrhagic stroke as a complication of essential hypertension ≥6 months ago. The control group included patients with essential hypertension, stage II. In both groups of patients, the parameters of 24-hour ambulatory blood pressure monitoring and electrocardiogram were determined. Results. The indices of 24-hour ambulatory blood pressure monitoring in the main group and the control group were the following ones, respectively: the mean daytime systolic blood pressure was 109,6±1,6 and 121,1±1,1 mm Hg, the minimal one was 74,4±2,0 mm Hg and 82,3±12,5 mm Hg, and the maximal one was 168,2±1,9 and 161,9±1,7 mm Hg, p<0,05. The daytime sigma systolic blood pressure (17,9±0,6) and its average real variability of (11,31±2,52 mm Hg) were bigger in the main group (p<0,05). The daytime index of the hyperbaric load of systolic blood pressure was bigger in the main group: it was 403,6±25,9 against 231,7±12,1 mm Hg×h in the comparison group (p<0,05). The mean, minimum and maximum heart rate at night were significantly lower in the main group (p<0,05). The QTcmin index was significantly lower in the main group in contrast to the control one – 286,28±43,34 and 336,69±22,55, and the QT variance was greater – 232,56±44,55 – in comparison to the control group (188,31±33,67) (p<0,05). From the anamnestic data of patients, a significantly higher prevalence of mild traumatic brain injury was found in 37,4% (35 patients out of 94) in the main group relative to the control one – 13,5% (14 out of 104), p<0,05. Conclusions: The results of the study indicate the larger ranges of blood pressure variability in patients with essential hypertension complicated with hemorrhagic stroke, which can be caused by impaired autoregulation according to the QTc interval data. In combination with the disturbances of cerebral circulation, caused by the injury of the brain due to the hemorrhagic stroke alone or in combination with mild traumatic brain injury episode, such a situation may lead to the development of recurrent stroke.

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Evaluation of Cardiovascular Dysregulation in Patients After Hemorrhagic Stroke as a Complication of Essential Hypertension

Tkachyshyn

2021

USMYJ

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Short QT Interval and Short QT Syndrome

Sano

2019

Ped Cardiol Card Surg

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Short QT syndrome (SQTS) is a hereditary lethal arrhythmia; it was first described in 2000. SQTS is characterized by an abnormal short QT interval on electrocardiogram (ECG), and causes arrhythmia, such as ventricular fibrillation and atrial fibrillation. Although clinical characteristics of SQTS have not been appropriately elucidated, several victims, individuals in the teenage and those in their 20s, have been reported. Therefore, SQTS diagnosis at an early age is important and is recognized as a concern in a school screening program for heart disease. According to an expert consensus statement published in 2013, even an asymptomatic individual with a short QT interval, who has neither a family history nor a pathogenic gene mutation, can be diagnosed with SQTS. Studies with various adult populations have identified individuals who met the SQTS diagnostic criteria; however, these patients were asymptomatic and did not have a poor prognosis. Some asymptomatic children and adolescents with SQTS were also identified in our study, in which we mainly focused on a school screening program for heart disease. Risk stratification of SQTS is necessary because clinical characteristics of SQTS are variable, including no symptoms and sudden cardiac death. Hence, we compared the ECGs of asymptomatic individuals with a short QT interval in a school screening program for heart disease with those of previously reported symptomatic patients with SQTS, to screen for SQTS patients with a high risk. A prospective study thus needs to be conducted to elucidate the prognosis of asymptomatic patients with SQTS who are diagnosed in their childhood.

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Sudden Cardiac Death and Short QT Syndrome

Cited by 2 publications

References 10 publications

Evaluation of Cardiovascular Dysregulation in Patients After Hemorrhagic Stroke as a Complication of Essential Hypertension

Evaluation of Cardiovascular Dysregulation in Patients After Hemorrhagic Stroke as a Complication of Essential Hypertension

Short QT Interval and Short QT Syndrome

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