Angiotensin-converting Enzyme Genetic Polymorphism

Wiwanitkit, Somsri; Wiwanitkit, Viroj

doi:10.5935/abc.20140077

Cited by 2 publications

(3 citation statements)

References 7 publications

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“…34 They also contribute to activation of MMP and increases in oxidative stress and cell death through apoptosis and necrosis, in addition to their effect on salt and water retention and vasoconstriction, which will be discussed further in the following section. [35][36][37] Angiotensin II independently promotes cardiac remodeling through increased perivascular and interstitial collagen content as well as direct cytotoxic effects on cardiomyocytes promoting apoptosis and cellular hypertrophy. 38 The changes modulated through angiotensin II can be directly enhanced by chronic SNS activation which can, on its own, promote cardiomyocyte apoptosis.…”

Section: Neurohumoral Regulationmentioning

confidence: 99%

Left Ventricular Reverse Remodeling in Heart Failure: Remission to Recovery

Boulet

Mehra

2021

Structural Heart

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Section: Neurohumoral Regulationmentioning

confidence: 99%

Left Ventricular Reverse Remodeling in Heart Failure: Remission to Recovery

Boulet

Mehra

2021

Structural Heart

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“…ACE is a key component of renin-angiotensin-aldosterone system that has a wide-ranging impact on human body. ACE I/D polymorphism has an important in uence on ACE level [4]. ACTN3 is closely related to muscle function, while XX genotype of ACTN3 gene leads to ACTN3 complete de ciency [5].…”

mentioning

confidence: 99%

“…ACTN3 is closely related to muscle function, while XX genotype of ACTN3 gene leads to ACTN3 complete de ciency [5]. In general populations of different ethnicities, it is common to carry ACE D or ACTN3 X mutation allele [4,5].…”

mentioning

confidence: 99%

The relationships between ACE I/D and ACTN3 R577X genetic polymorphisms and the response to short-term high-altitude exercise training

Liu

2023

Preprint

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Evidence strongly shows that ACE I/D and ACTN3 R577X genetic polymorphisms are closely related to outstanding exercise performance. This study explored the relationships between the two polymorphisms and the response to short-term high-altitude exercise training. 49 young Han nationality male subjects who were newcomers to high-altitude were selected. At 3200-m high-altitude, the subjects were trained for 4 weeks, and 30-m × 2 snake run, pull-up, sit-up and 3000-m run were tested before and after training. ACE gene was grouped by II and ID + DD genotypes, and ACTN3 gene was grouped by RR and RX + XX genotypes. Results showed that the performances of ACE ID + DD groups were both slight lower than II groups in pull-up and sit-up before training, while no differences after adjusting for covariates (age, body mass index and pre-training baseline) after training. No differences existed between the groups in 30-m × 2 snake run and 3000-m run, whether before training or after training. No ACE gene × training interactions were found in all exercise indicators. For ACTN3 gene, no significances were observed. Results suggest that ACE I/D polymorphism maybe have slight effect on the response to short-term high-altitude strength training. The discussion on the results implies that enough training duration and intensity are probably important in achieving significant gene × training interaction, and there may be the difference of gender in the interaction for ACTN3 gene.

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Angiotensin-converting Enzyme Genetic Polymorphism

Cited by 2 publications

References 7 publications

Left Ventricular Reverse Remodeling in Heart Failure: Remission to Recovery

Left Ventricular Reverse Remodeling in Heart Failure: Remission to Recovery

The relationships between ACE I/D and ACTN3 R577X genetic polymorphisms and the response to short-term high-altitude exercise training

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