Clinically Manifested Myocarditis in Acute Rheumatic Fever

Xavier, José L.; Soeiro, Alexandre de Matos; Lopes, Antonio S; Spina, Guilherme Sobreira; Serrano, Carlos; Oliveira, Múcio Tavares de

doi:10.5935/abc.20140017

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…Importantly, collagen sponges are already used in clinical practice for bone regeneration, so incorporation of this nanosilicate/growth factor system into a pre-established material could expedite clinical translation. Moreover, nanosilicates can also be combined with various ranges of natural and synthetic polymeric hydrogel systems including gelatin, 19,51 kappa carrageenan, 36,52 and poly(ethylene oxide) 53 for sustained and prolonged delivery of therapeutic proteins. These nanocomposite systems have been investigated for both injectable systems 54 and 3D printed constructs.…”

Section: Nanosilicate/tgf-β 3 Delivery Promotes Chondrogenic Differenmentioning

confidence: 99%

Sustained and Prolonged Delivery of Protein Therapeutics from Two-Dimensional Nanosilicates

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Ding

et al. 2019

ACS Appl. Mater. Interfaces

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We present a nanoengineered system for sustained and prolonged delivery of protein therapeutics, which has the potential to impact current orthopedic regeneration strategies. Specifically, we introduce two-dimensional nanosilicates with a high surface area and charged characteristics for delivery of active proteins for more than 30 days. The nanosilicates show high binding efficacy without altering the protein conformation and bioactivity. The released proteins are able to maintain high activity as demonstrated by enhanced differentiation of human mesenchymal stem cells at 10-fold lower concentration compared to the exogenous control. Utilizing the nanosilicates as a delivery vehicle could minimize the negative side effects observed because of the use of supraphysiological dosages of protein therapeutics for orthopedic regeneration strategies.

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Section: Nanosilicate/tgf-β 3 Delivery Promotes Chondrogenic Differenmentioning

confidence: 99%

Sustained and Prolonged Delivery of Protein Therapeutics from Two-Dimensional Nanosilicates

Cross

Carrow

Ding

et al. 2019

ACS Appl. Mater. Interfaces

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“…Its presence remains in the UK serving as a reminder that suspected ARF cases should always undergo echocardiographic assessment to identify subclinical valvulitis, to allow appropriate prophylaxis against RHD 7 16Multiple choice questions

The prevalence of rheumatic fever is?

…”

Section: Discussionmentioning

confidence: 99%

Fifteen-minute consultation: rheumatic fever

Markham

Tulloh

2015

Arch Dis Child Educ Pract Ed

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“…The echocardiography allows assessing the intensity of the valvular lesion, pericardial effusion, ventricular and atrial dilatation, and ventricular dysfunction. 10 Therefore, rheumatic fever does not seem to be the most likely cause for this cardiopathy with dilatation and rapid and progressive aggravation. In addition, the clinical and image findings in this case are not those of rheumatic cardiopathy.…”

Section: Clinical Aspectsmentioning

confidence: 99%