Back to Basics: PCSK9 as a New Target for the LDL Receptor

Corral, Pablo

doi:10.5935/abc.20130248

Cited by 3 publications

(2 citation statements)

References 10 publications

(17 reference statements)

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“…After the blood draw procedure volunteers, tests of total cholesterol, triglycerides and serum concentrations of LDL and HDL, C-reactive protein, latosterol, β-sitosterol, campesterol and plasma levels of PCSK9, also called convertase 1, an enzyme that interacts directly with LDL receptors, decreasing its metabolism [25]. In conclusion, consumption of short-term buttermilk significantly reduced total serum cholesterol and triglyceride concentrations.…”

Section: Hypocholesterolemic Activitymentioning

confidence: 86%

Technological and Biological Properties of Buttermilk: A Minireview

Mascarello¹,

Pinto²,

Araújo³

et al. 2019

Whey - Biological Properties and Alternative Uses

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Buttermilk is a by-product obtained from the batting insertion in the process of obtaining cream and butter and it is constituted by fat globules which are surrounded by milk fat globule membranes (MFGMs). During the stirring process, the membrane is ruptured and the various components present therein are released. Because it has a high nutritional content and low cost, buttermilk has drawn attention in the prospect of new forms of application. In addition, its disposal is expensive and not biologically viable. The objective of this work is to present a compilation of the technological and biological activities of buttermilk. Among the technological properties, it is worth mentioning its application as in the production of functional foods, a conduit for the incorporation of probiotics, inhibition of bacterial adherence on industrial surfaces, as well as the encapsulation of easily degraded activities and fermentative processes. Among the biological properties, its antioxidant, hypocholesterolemic, antimicrobial, and anticancer activities stand out. In conclusion, the reuse of buttermilk is economically and sustainably viable and encourages increasing research related to its use.

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Section: Hypocholesterolemic Activitymentioning

confidence: 86%

Technological and Biological Properties of Buttermilk: A Minireview

Mascarello¹,

Pinto²,

Araújo³

et al. 2019

Whey - Biological Properties and Alternative Uses

View full text Add to dashboard Cite

show abstract

“…This auto-cleavage process of PCSK9 is crucial for both its activation and release from the endoplasmic reticulum. 11 , 14 PCSK9 binds to the LDLR and directs the receptors for lysosomal destruction, thus reducing their recycling and decreasing the removal rate of circulating LDL-C with a subsequent increase of the LDL-C levels in the blood. 11 , 15 – 19 Gain-of-function mutations of PCSK9 in humans are linked to hypercholesterolaemia and elevated risk of CAD, 20 , 21 whereas loss-of-function mutations of PCSK9 are linked to low LDL-C levels and reduced cardiovascular risk.…”

Section: Reviewmentioning

confidence: 99%