The Echocardiography in the Cardiovascular Laboratory: A Guide to Research with Animals

Abduch, Maria Cristina Donadio; Assad, Renato S.; Mathias, Wilson; Aiello, Vera Demarchi

doi:10.5935/abc.20130239

Cited by 11 publications

(22 citation statements)

References 33 publications

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“…In this study, we used a noninvasive and rapid method, to evaluate the ventricular anatomy. Although the cut-off point for normal relative parietal thickness in humans is 0.42 mm, this criterion was highly speci c in our animals because the rats presented a relative parietal thickness below that limit [11,12]. Additionally, in this work the presence of Baker's cyst (QB), or popliteal cyst, was rst described in 1840 by Adams [16] and later by Baker [17].…”

Section: Discussionmentioning

confidence: 91%

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Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats

Coria

Estrada-Cruz

Ordoñez

et al. 2020

Preprint

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Background: Modern imaging plays a central role in the care of obese patients, and there is an integral focus on its use and accessibility in individuals who have alterations of various in various organs. The objective in this study was to perform an echographic analysis of musculoskeletal system disorders, endothelial dysfunction and the left ventricle (LV) in obese rats. Methods: Sprague Dawley rats (250±5g) were obtained and divided into two groups: the control (C) group was fed with a standard diet, and the obese (Ob) group was fed hyper caloric diet with a high fructose-fat content for 4 months. Body weight, cholesterol, triglycerides, glucose, inflammatory cytokines and adhesion molecules (ICAM-1, VCAM-1) were measured. Additionally, two-dimensional echocardiography, abdominal ultrasound and musculoskeletal system studies were performed in the lower extremities. Results: The body weight in the Ob group was increased compared to that in the control group, (p<0.001); in addition, increased glucose, cholesterol and triglyceride concentrations (p<0.05) as well as increased levels of the adhesion molecules ICAM-1 and, VCAM-1 (p<0.01) were found in the Ob group vs the C group. On ultrasound, 75% of the Ob group presented fatty liver and distal joint abnormalities. Conclusion: Obese rats exhibit endothelial dysfunction and musculoskeletal changes, also, fatty liver and articular cysts in the posterior region of the distal lower- extremity joints.

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Section: Discussionmentioning

confidence: 91%

“…Two-dimensional echocardiography is very useful for the study of congenital anomalies, the differentiation between thrombi and intracardiac masses, and the analysis of regions that are di cult to access via the one-dimensional echocardiogram [11].…”

Section: Introductionmentioning

confidence: 99%

Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats

Coria

Estrada-Cruz

Ordoñez

et al. 2020

Preprint

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“…In mammals, cardiac functional parameters such as fractional shortening, heart rate, cardiac output and end systolic and end diastolic volumes are measured via echocardiography (ECHO) [ 149 , 150 ]. By combining conventional echocardiography with modern speckle-tracking analyses, a recent study has overcome the challenge of small heart and body size of the adult zebrafish to perform highly sensitive non-invasive assessment of cardiac performance [ 151 ].…”

Section: Adult Functional Assaysmentioning

confidence: 99%

Advances in the Study of Heart Development and Disease Using Zebrafish

Brown

Samsa

et al. 2016

JCDD

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Animal models of cardiovascular disease are key players in the translational medicine pipeline used to define the conserved genetic and molecular basis of disease. Congenital heart diseases (CHDs) are the most common type of human birth defect and feature structural abnormalities that arise during cardiac development and maturation. The zebrafish, Danio rerio, is a valuable vertebrate model organism, offering advantages over traditional mammalian models. These advantages include the rapid, stereotyped and external development of transparent embryos produced in large numbers from inexpensively housed adults, vast capacity for genetic manipulation, and amenability to high-throughput screening. With the help of modern genetics and a sequenced genome, zebrafish have led to insights in cardiovascular diseases ranging from CHDs to arrhythmia and cardiomyopathy. Here, we discuss the utility of zebrafish as a model system and summarize zebrafish cardiac morphogenesis with emphasis on parallels to human heart diseases. Additionally, we discuss the specific tools and experimental platforms utilized in the zebrafish model including forward screens, functional characterization of candidate genes, and high throughput applications.

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“…Os transdutores utilizados em Medicina Veterinária são do tipo setorial e, atualmente, multifrequenciais de 2,5-3,5 MHz para cães adultos e de 4,0-8,0 MHz em cães de pequeno porte, filhotes e gatos (ABDUCH et al, 2014).…”

Section: Como Funciona O Transdutor De Ecocardiografia?unclassified

“…Em cães e gatos são representadas pelo terceiro e quarto espaços intercostais direito e esquerdo, cerca de 1 a 2 centímetros do bordo esternal e pelo quinto espaço intercostal esquerdo, na região do ictus (onde é possível sentir o choque de ponta do coração, correspondente ao sangue sendo ejetado através da aorta) (ABDUCH, 2004;ABDUCH et al, 2014). Nestes locais a ponta do sulco ou a fenda do transdutor (índex) deverão ser direcionadas à base do coração ou cranialmente para se obter a orientação correta (KEALY e Mc ALLISTER, 2005).…”

Section: Janelas Acústicas Planos Ou Eixos Dos Cortes Ecocardiográficosunclassified

A Ecocardiografia Nas Clínicas Veterinárias De Pequenos Animais: Roteiro Prático Para Graduandos Em Estágio

Conrado

Corredor-Castillo²,

Cardoso³

et al. 2017

INVESTIGACAO

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RESUMO ABSTRACTA Ecocardiografia é uma das áreas do rol da Imagenologia Veterinária em expansão nas clínicas veterinárias. Nesta revisão são descritas as noções básicas sobre o funcionamento dos equipamentos e a aquisição das imagens, a avaliação anatômica e fisiológica do coração a partir de modalidades de imagens em modo M (movimento) e em Doppler, além das alterações mais comuns observadas em exames ecocardiográficos de cães e gatos. Esta revisão é dirigida principalmente para alunos de Medicina Veterinária em estágio na área de diagnóstico por imagem.Palavras-chave: Cardiologia de pequenos animais, Doppler, ecocardiografia, estágio, modo M.Echocardiography is one of the areas of the Veterinary Imaging list in expansion in veterinary clinics. In this review it is described the basics of the operation of echocardiography equipment and the acquisition of the images, the anatomical and physiological assessment of heart in M-mode (motion mode) and Doppler images, besides the more common changes seen in echocardiographic examination of dogs and cats. This review is addressed primarily for students of Veterinary Medicine in diagnostic imaging internship.

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The Echocardiography in the Cardiovascular Laboratory: A Guide to Research with Animals

Cited by 11 publications

References 33 publications

Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats

Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats

Advances in the Study of Heart Development and Disease Using Zebrafish

A Ecocardiografia Nas Clínicas Veterinárias De Pequenos Animais: Roteiro Prático Para Graduandos Em Estágio

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