Mechanical Dyssynchrony is Similar in Different Patterns of Left Bundle-Branch Block

Barretto, Rodrigo Bellio de Mattos; Piegas, Leopoldo Soares; Assef, Jorge Eduardo; Neto, José Francisco Melo; Resende, Thiago Uchoa; Moreira, Dalmo Antônio Ribeiro; Lebihan, D; França, Francisco Faustino; Meneghelo, Romeu Sérgio; Sousa, Amanda G.M.R.

doi:10.5935/abc.20130190

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…Such a delay generates interventricular dyssynchrony, i.e. the RV contracts before the LV [12], [70]. In addition, due to late-activation of the LV free wall with respect to the interventricular septum activation, an intraventricular dyssynchrony occurs in the LV, i.e., the interventricular septum contracts before the LV free wall [13].…”

Section: Heart Failure and Left Bundle Branch Blockmentioning

confidence: 99%

Contribution to the improvement of electrical therapies and to the comprehension of electrophysiological mechanisms in heart failure and acute ischemia using computational simulation

Garay¹,

Fernando²

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A better understanding of the mechanisms underlying ventricular arrhythmias, as well as an improvement of the associated electrical and pharmacological therapies, are a key factor to prevent sudden cardiac death in patients with structural and electrical heart diseases. An important cardiomyopathy that can lead to life-threatening ventricular arrhythmias is heart failure (HF). Patients with HF also often suffer from left bundle branch block (LBBB), which worsens their condition. Currently, the most effective treatment to these patients is cardiac resynchronization therapy (CRT). However, many patients are non-responders, so further studies are needed to improve this treatment.

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Section: Heart Failure and Left Bundle Branch Blockmentioning

confidence: 99%

Contribution to the improvement of electrical therapies and to the comprehension of electrophysiological mechanisms in heart failure and acute ischemia using computational simulation

Garay¹,

Fernando²

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Real-time three dimensional tte in quantification of left ventricular dyssynchrony

Mamedova

Prihod’ko

Lubimceva

et al. 2023

Transl. med. (Print)

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Background. The main problem in the patient selection for cardiac resynchronization therapy (CRT) is the lack of unified approaches to the definition of mechanical dyssynchrony (MD) and selection criteria.Objective. To reveal the dependence of the criteria of dyssynchrony in patients on the method and point of stimulation and to reveal the correlation of these data with the width of the QRS complex and the percentage of global two-dimensional longitudinal deformation.Design and methods. The study involved 12 patients with drug-compensated CHF of class II-IV, LVEF< 35 % and a QRS duration >130 ms, having CRT indications. All patients were intraoperatively injected with a retrograde transaortically guided electrode. During stimulation of each point (88 points), transesophageal Echo-KG (PE Echo-KG) was performed. TomTec and Philips Qlab 3DQ Advanced software was used for data analysis.Results. The segmental excursion and myocardial contractility differed significantly depending on the stimulation point. A moderate inverse correlation was found between ExcAvg, LVEF and QRS duration. There were a direct correlation of the SDI-16 and the QRS duration was shown, and an inverse correlation of SDI-16 with ExcAvg and LVEF. 2D longitudinal global strain was inversely correlated with the EF.Conclusion. The technique is useful for regional LV myocardial contractility assessment and patient selection and comparison of alternative approaches to LV pacing to improve response to CRT.

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Mechanical Dyssynchrony is Similar in Different Patterns of Left Bundle-Branch Block

Cited by 2 publications

References 35 publications

Contribution to the improvement of electrical therapies and to the comprehension of electrophysiological mechanisms in heart failure and acute ischemia using computational simulation

Contribution to the improvement of electrical therapies and to the comprehension of electrophysiological mechanisms in heart failure and acute ischemia using computational simulation

Real-time three dimensional tte in quantification of left ventricular dyssynchrony

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