Ventricular Arrhythmias and Left Ventricular Hypertrophy in Hypertrophic Cardiomyopathy

Mattos, Beatriz Piva e; Torres, Marco Antônio Rodrigues; Freitas, Valéria Centeno de; Scolari, Fernando Luís; Loreto, Melina Silva de

doi:10.5935/abc.20130078

Cited by 5 publications

(4 citation statements)

References 37 publications

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“…HCM is an arrhythmogenic heart disease, whose histopathological substrate characterized by hypertrophy, cell disarray, fibrosis and coronary microvascular disease favors the occurrence of lethal ventricular arrhythmias. 5,6,19,20 Risk stratification for SCD is based on observational data obtained in very selected populations. It is considered complex, due to the heterogeneous character of the disease, and imperfect because many deaths occur in the absence of risk predictors.…”

Section: Discussionmentioning

confidence: 99%

Discordância entre Diretrizes Internacionais sobre Critérios de Prevenção Primária de Morte Súbita na Cardiomiopatia Hipertrófica

Mattos

Scolari

Garbin

2020

Arquivos Brasileiros De Cardiologia

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Background: Risk stratification for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) is based on different algorithms proposed by the 2011 ACCF/AHA and 2014 ESC guidelines. Objective: To analyze the 2014 ESC model for SCD risk stratification and primary prevention ICD (implantable cardioverter defibrillator) in HCM in comparison to the North American guideline. Methods: An HCM cohort was evaluated and the ESC HCM-Risk SCD score was calculated. Agreement of ICD recommendations criteria between the two guidelines was analyzed with Kappa coefficient. P<0.05 was adopted for the statistical analysis. Results: In 90 consecutive patients followed for 6±3 years, the mean calculated ESC risk score was 3.2±2.5%. The risk predictors that have mainly contributed to the score calculation in the low (1.88% [1.42-2.67]), intermediate (5.17% [4.89-5.70]) and high-risk (7.82% [7.06-9.19]) categories were: maximal left ventricular wall thickness (1.

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Section: Discussionmentioning

confidence: 99%

Discordância entre Diretrizes Internacionais sobre Critérios de Prevenção Primária de Morte Súbita na Cardiomiopatia Hipertrófica

Mattos

Scolari

Garbin

2020

Arquivos Brasileiros De Cardiologia

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“…It is characterized by myocardial growth, causing hypertrophy and odd structural disorganization of cardiomyocytes in a diffuse way as well as fibrosis of varying degrees, being listed in the genesis of ventricular arrhythmias, which in turn are related to the risk of sudden death. 9 , 10 …”

Section: Discussionmentioning

confidence: 99%

“…The case of this patient suggests no development of arterial rigidity with aging and thus turns out to be protected from the effects of low compliance. 10 …”

Section: Discussionmentioning

confidence: 99%

Ehlers-Danlos Syndrome associated with cardiomyopathy hypertrophic obstructive

Pinto

Santos

Azevedo

et al. 2015

An. Bras. Dermatol.

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Ehlers-Danlos syndrome is a rare clinical condition caused by a genetic change that results in the formation of structurally or functionally altered collagen. The clinical manifestations are varied, being the most obvious skin hypermotility and increased joint flexibility, although other systems - such as cardiovascular, respiratory and neurological - may also be affected. This paper presents the report of a patient who sought medical attention with complaints of atypical chest pain. Clinical evaluation enabled hypothetical diagnosis of hypertrophic obstructive cardiomyopathy and Ehlers-Danlos syndrome. Initial electrocardiogram, echocardiogram and 24 hours holter allowed the confirmation of the first hypothesis. A skin biopsy performed later associated clinical data and confirmed the second hypothesis.

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“…Ventricular arrhythmia is a typical characteristic of HOCM, a disease that is considered unpredictable due to its arrhythmogenic potential [11]. Severe left ventricular hypertrophy is associated with a higher incidence of SCD [4,5].…”

Section: Discussionmentioning

confidence: 99%

Long-Term Prognosis after Myectomy in Hypertrophic Obstructive Cardiomyopathy with Severe Left Ventricular Hypertrophy

An¹,

Fan²,

Yang³

et al. 2018

Cardiology

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Objectives: Patients with hypertrophic obstructive cardiomyopathy (HOCM) and severe left ventricular hypertrophy (maximal left ventricular wall thickness ≥30 mm) are at high risk of sudden cardiac death (SCD). In this study, we aimed to determine whether HOCM patients with severe hypertrophy had a lower incidence of SCD after myectomy. Methods: HOCM patients with severe hypertrophy were consecutively enrolled from Fuwai Hospital in China between 2000 and 2013. Long-term outcomes were retrospectively compared between the 2 groups, namely the myectomy group and medical group. Results: A total of 244 patients (118 in the myectomy group and 126 in the medical group) were involved. The mean follow-up durations for the myectomy and medical groups were 5.07 ± 3.73 and 6.23 ± 4.15 years, respectively. During the follow-up period, the annual cardiovascular mortality rate was 0.84% in the myectomy group and 2.04% in the medical group (p = 0.041). The annual SCD rate was 0.33% in the myectomy group and 1.40% in the medical group (p = 0.040). Multivariate Cox regression analysis showed that myectomy was independently associated with lower rates of cardiovascular death and SCD. Conclusions: In HOCM patients with severe hypertrophy, those that underwent myectomy had a lower risk of cardiovascular death and SCD than those treated with medicines only.

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Ventricular Arrhythmias and Left Ventricular Hypertrophy in Hypertrophic Cardiomyopathy

Abstract: In HCM, occurrence of ventricular arrhythmias by Holter was associated with the degree of LVH assessed by echocardiography through MWT and BMI.

Cited by 5 publications

References 37 publications

Discordância entre Diretrizes Internacionais sobre Critérios de Prevenção Primária de Morte Súbita na Cardiomiopatia Hipertrófica

Discordância entre Diretrizes Internacionais sobre Critérios de Prevenção Primária de Morte Súbita na Cardiomiopatia Hipertrófica

Ehlers-Danlos Syndrome associated with cardiomyopathy hypertrophic obstructive

Long-Term Prognosis after Myectomy in Hypertrophic Obstructive Cardiomyopathy with Severe Left Ventricular Hypertrophy

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