Heart Neoplasms in Children: Retrospective Analysis

Penha, Juliano Gomes; Zorzanelli, Leína; Barbosa-Lopes, Antônio Augusto; Aiello, Vera Demarchi; Carvalho, Vitor Oliveira; Canêo, Luiz Fernando; Riso, Arlindo de Almeida; Tanamati, Carla; Atik, Edimar; Jatene, Marcelo Biscegli

doi:10.5935/abc.20130024

Cited by 12 publications

(8 citation statements)

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“…1,4 Owing to the higher incidence of spontaneous regression, surgical intervention after birth should be undertaken when there is cardiac inflow, outflow obstruction, or intractable arrhythmia. 5 Surgery may be challenging in cases with multiple rhabdomyomas in multiple different sites. There are only two previous reports about rhabdomyoma cases that showed regression under medical treatment.…”

Section: P Rimary Cardiac Tumours Are Rare In Paediatricmentioning

confidence: 99%

Everolimus treatment of a newborn with rhabdomyoma causing severe arrhythmia

2014

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Rhabdomyoma is the most common cardiac tumour in children often associated with tuberous sclerosis. Arrhythmia caused by cardiac rhabdomyomas may be the initial sign of tuberous sclerosis. Rhabdomyomas unresponsive to other treatments could be successfully managed with everolimus, which has demonstrated benefit in tuberous sclerosis. We report a case of rhabdomyoma causing severe arrhythmia in a newborn managed successfully with everolimus.

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Section: P Rimary Cardiac Tumours Are Rare In Paediatricmentioning

confidence: 99%

Everolimus treatment of a newborn with rhabdomyoma causing severe arrhythmia

2014

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“…The other symptoms observed in heart tumors are murmur, tachypnea, cyanosis, manifestations of heart failure, and various types of arrhythmia [ 13 , 14 , 15 ]. Older patients reported a reduction in the tolerance for physical activity, as well as arrhythmia, dyspnea, fainting, and chest pain.…”

Section: Discussionmentioning

confidence: 99%

Echocardiography and Newer Imaging Techniques in Diagnosis and Long-Term Follow-Up of Primary Heart Tumors in Children

Morka

Kohut

Radzymińska-Chruściel³

et al. 2020

IJERPH

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Background: Primary heart tumors (PHTs) in the pediatric population are very rare and do not manifest any characteristic symptoms. Methods: A retrospective analysis of 61 cases was undertaken. Data from three centers for the years 2003–2018 were gathered. The tumors’ clinical course, location, number, hemodynamic, treatment, and follow-up were evaluated. Echocardiography was complemented with magnetic resonance imaging, computer tomography, and histopathological examination. Results: Out of 61 PHT diagnoses, 56 (91.8%) were circumstantial including all 16 (26.2%) prenatal tumors. The reasons for cardiological consultations were arrhythmia, syncopes, lowered physical performance, and murmurs. Only five patients (8.2%) were suspected of tumors based on previous symptoms of sclerosis tuberosa. Rhabdomyoma was the most frequently found PHT (60.7%). The tumors were predominantly located in the ventricles (49.1%) and intraventricular septum (14.9%) and tended to be single (70.5%). About 37.7% of patients suffered from coexistent multi-organ problems, two (3.28%) from congenital heart defects and one (1.64%) from Carney’s syndrome. Tumor resection was performed on 26 (42.7%) patients, of which 16 (61.5%) underwent total and 10 (38.5%) partial tumor resection. During the follow-up (mean 4.3 years), 54 patients (88.5%) have improved or were stable, while seven (11.5%) died. Conclusions: Primary pediatric heart tumors are diagnosed completely circumstantially, and the most common is rhabdomyoma, although arrhythmia may suggest fibroma. Diagnosis of a heart tumor in children is not synonymous with fatal prognosis, and most of them require only constant observation. Life-saving operation allows improvement, while the prognosis for malignant tumors in children is definitely unfavorable.

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“…The most common indication for surgery has been flow obstruction,[ 3 6 ] of which outflow obstruction is significantly more common than inflow obstruction. Surgery has been the definitive treatment, occasionally on an urgent basis.…”

Section: Discussionmentioning

confidence: 99%

“…Rhabdomyoma is considered the most common cardiac tumor in childhood. [ 1 2 3 4 5 6 7 8 ] In general, rhabdomyomas are multiple, well circumscribed, noncapsulated nodules, found most commonly in the ventricles. They may cause obstruction of blood flow and or arrhythmias.…”

Section: Introductionmentioning

confidence: 99%

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Perioperative management of critical right ventricular inflow obstruction from right atrial rhabdomyoma

Norawat

Sarkar

Maybauer³

2018

Ann Card Anaesth

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Rhabdomyoma is the most common cardiac tumor in infancy and commonly located in the ventricles causing outflow obstruction or arrhythmias. We report a rare pediatric (7 month old) case of a right atrial rhabdomyoma presenting with severe cyanosis and low cardiac output from significant tricuspid inflow obstruction with right to left shunt across a stretched patent foramen ovale. We present an emergency cardiac surgery for right atrial tumor resection, and the management of separating the patient with failing right ventricle from cardiopulmonary bypass using a Glenn shunt, since extracorporeal membrane oxygenation (ECMO) or nitric oxide was not available.

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Heart Neoplasms in Children: Retrospective Analysis

Cited by 12 publications

References 0 publications

Everolimus treatment of a newborn with rhabdomyoma causing severe arrhythmia

Everolimus treatment of a newborn with rhabdomyoma causing severe arrhythmia

Echocardiography and Newer Imaging Techniques in Diagnosis and Long-Term Follow-Up of Primary Heart Tumors in Children

Perioperative management of critical right ventricular inflow obstruction from right atrial rhabdomyoma

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