Genetic Polymorphisms and Generalized Anxiety Disorder: a systematic review

Alves, Verônica de Medeiros; Moura, Edilson Leite de; Correia, Larissa Tenório Andrade; Nardi, Antônio Egídio

doi:10.5935/medicalexpress.2017.01.01

Cited by 2 publications

(2 citation statements)

References 31 publications

(43 reference statements)

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“…More interestingly, anxiety disorder and pain share the same pathway that gives us more chance to focus on the polymorphism of the HTR3A gene to manage chronic pain [ 31 , 35 , 36 ]. DRD2 is also a risk gene related to GAD and may predict mental disorders at an early age [ 37 , 38 ]. SLC6A4 gene, which is a serotonin transporter gene, encodes a membrane protein through the transportation of serotonin to play a role in GAD [ 39 , 40 ].…”

Section: Summary and Discussionmentioning

confidence: 99%

Analysis of the Underlying Mechanism of the Jiu Wei Zhen Xin Formula for Treating Generalized Anxiety Disorder Based on Network Pharmacology of Traditional Chinese Medicine

Shao

Gan

Chen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Currently, there are many effective pharmacological treatments for generalized anxiety disorder (GAD), formulated herbal granule is also an alternative way. Our research intends to construct a pharmacological network on genetic targets and pathways between Jiu Wei Zhen Xin Formula (JWZXF) and GAD. Through the TCMSP database, we collected the active ingredients of JWZXF and potential targets of the active ingredients. The GAD-related proteins collected from GeneCards database and DisGeNET database were combined. Component-target protein networks were constructed and visualized using Cytoscape 3.8.2 software to comprehensively clarify the relationships between ingredients, components, and targets. The intersection targets were imported into the STRING database, and the protein-protein interaction (PPI) network was constructed. We constructed and analyzed the visualized “drug-target-disease” network. Gene Ontology (GO) enrichment together with Kyoto encyclopedia of genes and genomes (KEGG) enrichment analysis were conducted on the common target through R language. Forty-one effective components and 106 potential targets of JWZXF were found. There were top ten hub genes and multiple important signaling pathways involved in the treatment of GAD with the JWZXF. This study expounded the pharmacological actions and molecular mechanisms of the JWZXF in treating GAD from a holistic perspective. The potential pharmacological effects of the JWZXF are closely related to regulation because not only does it comprehensively analyze the possible mechanism of JWZXF treatment of GAD but it can also facilitate further in-depth research and provide a theoretical basis for the clinical expansion of its application.

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Section: Summary and Discussionmentioning

confidence: 99%

Analysis of the Underlying Mechanism of the Jiu Wei Zhen Xin Formula for Treating Generalized Anxiety Disorder Based on Network Pharmacology of Traditional Chinese Medicine

Shao

Gan

Chen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Although we find that environmental influences shared between twins mostly explain the overlap between anxiety and lower baroreflex control, genetic influences should not be ruled out. More recently, genome-wide association studies (GWAS) have begun highlighting common genetic variants associated with anxiety (Alves et al, 2017;Gottschalk & Domschke, 2017;Purves et al, 2019) and cardiovascular functions (Nolte et al, 2017;Sigurdsson et al, 2018). This approach provides insight into genetic etiology at a molecular level and paves the way for polygenic risk scores to identify individuals at-risk for anxiety and autonomic dysfunction.…”

Section: Limitations and Future Directionsmentioning

confidence: 99%

Higher Anxiety Is Associated with Lower Cardiovascular Autonomic Function in Female Twins

et al. 2020

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AbstractAnxiety symptoms co-occur with cardiovascular health problems, with increasing evidence suggesting the role of autonomic dysfunction. Yet, there is limited behavior genetic research on underlying mechanisms. In this twin study, we investigated the phenotypic, genetic and environmental associations between a latent anxiety factor and three cardiovascular autonomic function factors: interbeat interval (IBI, time between heart beats), heart rate variability (HRV, overall fluctuation of heart-beat intervals) and baroreflex sensitivity (BRS, efficiency in regulating blood pressure [BP]). Multivariate twin models were fit using data of female twins (N = 250) of the Twin Interdisciplinary Neuroticism Study (TWINS). A significant negative association was identified between latent anxiety and BRS factors (r = −.24, 95% CI [−.40, −.07]). Findings suggest that this relationship was mostly explained by correlated shared environmental influences, and there was no evidence for pleiotropic genetic or unique environmental effects. We also identified negative relationships between anxiety symptoms and HRV (r = −.17, 95% CI [−.34, .00]) and IBI factors (r = −.13, 95% CI [−.29, .04]), though these associations did not reach statistical significance. Findings implicate that higher anxiety scores are associated with decreased efficiency in short-term BP regulation, providing support for autonomic dysfunction with anxiety symptomatology. The baroreflex system may be a key mechanism underlying the anxiety–cardiovascular health relationship.

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Genetic Polymorphisms and Generalized Anxiety Disorder: a systematic review

Cited by 2 publications

References 31 publications

Analysis of the Underlying Mechanism of the Jiu Wei Zhen Xin Formula for Treating Generalized Anxiety Disorder Based on Network Pharmacology of Traditional Chinese Medicine

Analysis of the Underlying Mechanism of the Jiu Wei Zhen Xin Formula for Treating Generalized Anxiety Disorder Based on Network Pharmacology of Traditional Chinese Medicine

Higher Anxiety Is Associated with Lower Cardiovascular Autonomic Function in Female Twins

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