2015
DOI: 10.5935/medicalexpress.2015.03.02
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Efficacy, efficiency and effectiveness of gonadotropin therapy for infertility treatment

Abstract: Gonadotropin therapy is an essential element in infertility treatments involving assisted reproductive technology. In recent years there have been outstanding advances in the development of new gonadotropins, particularly with the production of gonadotropins using biotechnological resources. Recombinant gonadotropins have higher specific activity compared with urinary counterparts, thus allowing subcutaneous administration of minimal amounts of glycoprotein. As a result, recombinant formulations have a better … Show more

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Cited by 10 publications
(8 citation statements)
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References 59 publications
(119 reference statements)
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“… Source: Adapted from Esteves, 80 with permission granted via Creative Commons Attribution non-commercial 4.0 copyright public licence. …”
Section: Suppression and Recovery Of Spermatogenesismentioning
confidence: 99%
“… Source: Adapted from Esteves, 80 with permission granted via Creative Commons Attribution non-commercial 4.0 copyright public licence. …”
Section: Suppression and Recovery Of Spermatogenesismentioning
confidence: 99%
“…Furthermore, through these cells, this hormone indirectly Conversely, in women presenting ovulatory dysfunction, FSH treatment has been recommended for decades; for example, using human chorionic gonadotropin (hCG) and human menopausal gonadotropin (hMG) to stimulate the growth and ovulation of the dominant follicle in patients presenting anovulatory infertility. Novel therapies using biotechnology have been introduced; for example, recombinant gonadotrophin, which is purer than urinary-derived gonadotropins and shows better clinical efficiency [35,45,46]. Recombinant human FSH (rhFSH) has been shown to be efficient in patients with polycystic ovary syndrome (PCOS), which is anovulatory, in stimulating follicular growth [47][48][49].…”
Section: Introductionmentioning
confidence: 99%
“…Later in 2000, recombinant hCG preparations became available ( 13 ). Currently, urinary and recombinant hCG preparations are widely available from several commercial sources ( 25 ), as they are commonly used in the management of infertility and prepubertal cryptorchidism, as well as for stimulating testosterone production in hypogonadal men.…”
Section: History Of Human Chorionic Gonadotropinmentioning
confidence: 99%