Parameters involved and viability of immunosuppression on islet allotransplantation procedure in rodents

Iuamoto, Leandro Ryuchi; Meyer, Alberto; Chaib, Eleazar; D’Albuquerque, Luiz Carneiro

doi:10.5935/medicalexpress.2014.04.06

Cited by 1 publication

(2 citation statements)

References 22 publications

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“…The islet transplantation technique has been developed to provide an adequate supply of insulin, which solves the problem of donor shortage for diabetic patients 17 . From 1991 to 2000, 450 islet transplantation attempts were performed in patients with type 1 diabetes with only an 8% success rate.…”

Section: Discussionmentioning

confidence: 99%

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Human islet xenotransplantation in rodents: A literature review of experimental model trends

Iuamoto¹,

Franco²,

Suguita³

et al. 2017

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Among the innovations for the treatment of type 1 diabetes, islet transplantation is a less invasive method of treatment, although it is still in development. One of the greatest barriers to this technique is the low number of pancreas donors and the low number of pancreases that are available for transplantation. Rodent models have been chosen in most studies of islet rejection and type 1 diabetes prevention to evaluate the quality and function of isolated human islets and to identify alternative solutions to the problem of islet scarcity. The purpose of this study is to conduct a review of islet xenotransplantation experiments from humans to rodents, to organize and analyze the parameters of these experiments, to describe trends in experimental modeling and to assess the viability of this procedure. In this study, we reviewed recently published research regarding islet xenotransplantation from humans to rodents, and we summarized the findings and organized the relevant data. The included studies were recent reports that involved xenotransplantation using human islets in a rodent model. We excluded the studies that related to isotransplantation, autotransplantation and allotransplantation. A total of 34 studies that related to xenotransplantation were selected for review based on their relevance and current data. Advances in the use of different graft sites may overcome autoimmunity and rejection after transplantation, which may solve the problem of the scarcity of islet donors in patients with type 1 diabetes.

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Section: Discussionmentioning

confidence: 99%

“…Although immunosuppressive drugs may increase the survival rates of islet allotransplantation in rodents by reducing the side effects 17 , few studies have used immunosuppressants. It was therefore not possible to perform an analysis of the immunosuppressive effect in islet xenotransplantation.…”

Section: Discussionmentioning

confidence: 99%