Dapagliflozin in patients with critical illness: rationale and design of the DEFENDER study
Caio de Assis Moura Tavares,
Luciano César Pontes de Azevedo,
Álvaro Rea-Neto
et al.
Abstract:Background
Critical illness is a major ongoing health care burden worldwide and is
associated with high mortality rates. Sodium-glucose cotransporter-2
inhibitors have consistently shown benefits in cardiovascular and renal
outcomes. The effects of sodium-glucose cotransporter-2 inhibitors in acute
illness have not been properly investigated.
Methods
DEFENDER is an investigator-initiated, multicenter, randomized, open-label
trial designed to evaluate the efficacy and sa… Show more
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