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“…Despite the powerful analgesic effect of morphine, this drug induces severe reactions, including tolerance, respiratory depression, and physical and psychological dependence ( Yamanaka and Sadikot, 2013 ; Esfandyari et al, 2018 ). Given this, the pharmaceutical industry is committed to developing new drugs with therapeutic activity similar to morphine but with reduced side effects, which are considered limiting factors to their use ( Hess et al, 2010 ; Vilella, 2018 ).…”
Section: Discussionmentioning
confidence: 99%
“…Despite the powerful analgesic effect of morphine, this drug induces severe reactions, including tolerance, respiratory depression, and physical and psychological dependence ( Yamanaka and Sadikot, 2013 ; Esfandyari et al, 2018 ). Given this, the pharmaceutical industry is committed to developing new drugs with therapeutic activity similar to morphine but with reduced side effects, which are considered limiting factors to their use ( Hess et al, 2010 ; Vilella, 2018 ).…”
Section: Discussionmentioning
confidence: 99%