Effect of Mild Aerobic Exercise in Atrial Granules of Mice with Chronic Chagas
            Disease

Ferraboli, Roberto; Ornelas, Elisabete de Marco; Fonseca, Fernando Luiz Affonso; Veiga, Gláucia Luciano da; Cardoso, Cléver Gomes; Marques, Mirian David; Maifrino, Laura Beatriz Mesiano

doi:10.5935/2359-4802.20180060

Cited by 3 publications

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“…In the acute phase of infection in Wistar rats, physical exercises are not recommended since they exacerbate inflammation in cardiac tissue and increase cytokine levels in serum (41). In experimental models of CCC, physical exercises improve morphological and morphometric parameters in heart tissue (42,43). In patients with CCC, physical exercises ameliorate cutaneous microvascular function, hemodynamics, ECHO, and clinical parameters (33,34,(44)(45)(46).…”

Section: Introductionmentioning

confidence: 99%

Physical Exercise Promotes a Reduction in Cardiac Fibrosis in the Chronic Indeterminate Form of Experimental Chagas Disease

et al. 2021

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Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, is a neglected tropical disease and a health problem in Latin America. Etiological treatment has limited effectiveness in chronic CD; thus, new therapeutic strategies are required. The practice of physical exercises has been widely advocated to improve the quality of life of CD patients. The most frequent clinical CD manifestation is the chronic indeterminate form (CIF), and the effect of physical exercises on disease progression remains unknown. Here, in a CIF model, we aimed to evaluate the effect of physical exercises on cardiac histological, parasitological, mitochondrial, and oxidative metabolism, electro and echocardiographic profiles, and immunological features. To establish a CIF model, BALB/c and C57BL/6 mice were infected with 100 and 500 trypomastigotes of the Y T. cruzi strain. At 120 days postinfection (dpi), all mouse groups showed normal PR and corrected QT intervals and QRS complexes. Compared to BALB/c mice, C57BL/6 mice showed a lower parasitemia peak, mortality rate, and less intense myocarditis. Thus, C57BL/6 mice infected with 500 parasites were used for subsequent analyses. At 120 dpi, a decrease in cardiac mitochondrial oxygen consumption and an increase in reactive oxygen species (ROS) were detected. When we increased the number of analyzed mice, a reduced heart rate and slightly prolonged corrected QT intervals were detected, at 120 and 150 dpi, which were then normalized at 180 dpi, thus characterizing the CIF. Y-infected mice were subjected to an exercise program on a treadmill for 4 weeks (from 150 to 180 dpi), five times per week in a 30–60-min daily training session. At 180 dpi, no alterations were detected in cardiac mitochondrial and oxidative metabolism, which were not affected by physical exercises, although ROS production increased. At 120 and 180 dpi, comparing infected and non-infected mice, no differences were observed in the levels of plasma cytokines, indicating that a crucial biomarker of the systemic inflammatory profile was absent and not affected by exercise. Compared with sedentary mice, trained Y-infected mice showed similar parasite loads and inflammatory cells but reduced cardiac fibrosis. Therefore, our data show that physical exercises promote beneficial changes that may prevent CD progression.

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Section: Introductionmentioning

confidence: 99%

Physical Exercise Promotes a Reduction in Cardiac Fibrosis in the Chronic Indeterminate Form of Experimental Chagas Disease

et al. 2021

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“…Plasmodium vivax is the leading cause of malaria in Latin America, responsible for thousands of malaria cases every year. In the article by Ferraboli et al , 5 the authors have conducted a comprehensive review of what is known about P. vivax transcriptomics. To that end, the authors revised important information on dominant protein expression in each life stage of the parasite, identifying transcription patterns related to pathogenesis and immune escape, as well as potential targets for vaccine development and anti-malarial therapy.…”

mentioning

confidence: 99%

Introduction to the thematic issue on infectious diseases: Highlights of the Brazilian virology conference 2022 and International Experimental Biology and Medicine Conference (IEBMC), Brazil 2022

da Fonseca,

Conran

2023

Exp Biol Med (Maywood)

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Effect of Mild Aerobic Exercise in Atrial Granules of Mice with Chronic Chagas Disease

Cited by 3 publications

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Physical Exercise Promotes a Reduction in Cardiac Fibrosis in the Chronic Indeterminate Form of Experimental Chagas Disease

Physical Exercise Promotes a Reduction in Cardiac Fibrosis in the Chronic Indeterminate Form of Experimental Chagas Disease

Introduction to the thematic issue on infectious diseases: Highlights of the Brazilian virology conference 2022 and International Experimental Biology and Medicine Conference (IEBMC), Brazil 2022

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