Aggressive fibromatosis (desmoid tumor) associated with breast implant: literature
            review and presentation of three new cases

Filho, Aloísio Ferreira da Silva; Alves, José Carlos Ribeiro Resende; Portugal, Erick Horta; Fonseca, Rebeca Paohwa Liu da; Almeida, Augusto César de Melo; Pereira, Nárlei Amarante; Silva, Frederico Lins E; Calsavara, Eduardo Ferreira; Filho, José de Souza Andrade

doi:10.5935/2177-1235.2017rbcp0060

Cited by 2 publications

(5 citation statements)

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“…2,4,6,7 To date, fewer than 50 cases of implant-related breast fibromatosis have been reported. [2][3][4][6][7][8][9][10][11][12][13] Reported cases are seen more often with silicone implants than saline implants, possibly due to the higher prevalence of the former. 6 Fibromatoses are usually reported to develop within 2 to 3 years of implant surgery.…”

Section: Discussionmentioning

confidence: 99%

“…2,6 The exact causal relationship between implants and fibromatosis is nonetheless unclear. 6,7,10 The implant material and trauma related to the surgery may both play a role in the development of fibromatoses in patients with breast implants; fibromatoses arising close to or adjacent to the fibrous capsule of a breast implant have been reported. 6,10,13 Our literature search revealed one case with silicone implant and intracapsular rupture.…”

Section: Discussionmentioning

confidence: 99%

“…6,7,10 The implant material and trauma related to the surgery may both play a role in the development of fibromatoses in patients with breast implants; fibromatoses arising close to or adjacent to the fibrous capsule of a breast implant have been reported. 6,10,13 Our literature search revealed one case with silicone implant and intracapsular rupture. 7 To the best of our knowledge, there has been no reported case of breast fibromatosis associated with free silicone injection.…”

Section: Discussionmentioning

confidence: 99%

“…The treatment of breast fibromatoses is evolving and remains controversial, but there had been discussion of surgery (most commonly described is wide local excision with clear margins), and systemic therapy with nonsteroidal anti-inflammatory drugs such as sulindac, hormone therapy with tamoxifen, and tyrosine kinase inhibitors have been used. [4][5][6][7][8]10,12,14 Radiotherapy is suggested to also play a role in management. [5][6][7][8]12 It should be kept in mind that local recurrence is not uncommon despite treatment, and follow-up is required.…”

Section: Discussionmentioning

confidence: 99%

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Breast-Implant-Related Fibromatosis in a Patient with Free Silicone Injection: a Case Report

Chan

Tsoi

Hung

et al. 2023

Hong Kong Journal of Radiology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Breast-Implant-Related Fibromatosis in a Patient with Free Silicone Injection: a Case Report

Chan

Tsoi

Hung

et al. 2023

Hong Kong Journal of Radiology

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“…Cell atypia and other signs of malignancy are not expected [5]. Immunohistochemistry is important for diagnosis, being positive for betacatenin and smooth muscle actin [10].…”

Section: Discussionmentioning

confidence: 99%

Axillary fibromatosis with radiological-pathological correlation: a case report and literature review

Sprenger

Kluppel

Filho

et al. 2021

Egypt J Radiol Nucl Med

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Background The term fibromatosis refers to a spectrum of soft tissue tumors resulting from the unbridled proliferation of fibroblasts, with high infiltrative power. It is a rare neoplasm, with an incidence of about 3 cases per million. Most common sites include the abdominal wall and cavity, chest wall, scapular area, and the limbs, rarely affecting the axilla. Imaging plays a major role in surgical planning and clinical follow-up. Differential diagnosis with other soft tissue tumors may be arduous, but a correct evaluation is fundamental. Case presentation A 33-year-old case is reported for the evaluation of a palpable hardened and immobile left axillary nodule. The ultrasound reveals a solid, elongated, heterogeneous, poorly delimited, infiltrative lesion observed in the left axillary hollow, with no detectable flow in the color Doppler mode. At magnetic resonance imaging, the same elongated and expansive lesion was better defined, revealing its irregular contours, alternating areas of hypo- and hyperintense on T2, heterogeneous enhancement, and no signs of signal decay on in- and out-of-phase sequences. Due to its growth and local invasion potential, surgical excision was performed. The microscopic analysis showed long and uniform spindle cell fascicles, with clear cytoplasm and wavy nuclei, arranged in different directions, included in collagen stroma. Immunohistochemistry was positive for nuclear beta-catenin, confirming the diagnosis of fibromatosis. Conclusion Imaging methods reflect the heterogeneous nature of the lesion. This study demonstrates the importance of using a multidisciplinary approach in addition to imaging tests and histopathological study for better diagnosis and therapeutic planning. The high infiltrative power always must be reminded of, since it affects young patients and diagnosis delay can lead to mutilating surgeries.

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Aggressive fibromatosis (desmoid tumor) associated with breast implant: literature review and presentation of three new cases

Cited by 2 publications

References 0 publications

Breast-Implant-Related Fibromatosis in a Patient with Free Silicone Injection: a Case Report

Breast-Implant-Related Fibromatosis in a Patient with Free Silicone Injection: a Case Report

Axillary fibromatosis with radiological-pathological correlation: a case report and literature review

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