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“…The extravasation leads to chronic edema of the dermal interstitium leading to local inflammation, fibrosis, and dermal and sebaceous gland hyperplasia [3,12,16]. There is evidence of associated genetic factors as cases of twins, uncles, or grandparents of patients affected have been described [18]. This goes with our two brother patients with rhinophyma.…”
Section: Discussionmentioning
confidence: 53%
“…The extravasation leads to chronic edema of the dermal interstitium leading to local inflammation, fibrosis, and dermal and sebaceous gland hyperplasia [3,12,16]. There is evidence of associated genetic factors as cases of twins, uncles, or grandparents of patients affected have been described [18]. This goes with our two brother patients with rhinophyma.…”
Section: Discussionmentioning
confidence: 53%