Multiple symmetrical lipomatosis (Madelung’s disease)✰✰Please cite this article as: Ikumi-Shibasaki I, Ikuo-Shibasaki H, Nakamoto TS, Baccan FS, Raposo LS. Multiple symmetrical lipomatosis (Madelung's disease). Braz J Otorhinolaryngol. 2014;80:90–1.

Shibasaki, Ísis Ikumi; Shibasaki, H.; Nakamoto, Tiago de Souza; Baccan, Flávia Scarinci; Raposo, Luiz Sérgio

doi:10.5935/1808-8694.20140018

Cited by 9 publications

(4 citation statements)

References 3 publications

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“…The incidence rate is approximately 1 in 25,000, and around 400 cases have been reported since the initial description by Brode in 1846. Up to 90% of MSL patients also suffer from chronic alcoholism 2 , whereas the underlying molecular mechanism is still enigmatic and there is no effective treatment for MSL.…”

mentioning

confidence: 99%

miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis

Chen

Xie

et al. 2015

Sci Rep

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Multiple symmetric lipomatosis (MSL) is a rare disease characterized by symmetric and abnormal distribution of subcutaneous adipose tissue (SAT); however, the etiology is largely unknown. We report here that miR-125a-3p and miR-483-5p are upregulated in the SAT of MSL patients, promoting adipogenesis through suppressing the RhoA/ROCK1/ERK1/2 pathway. TaqMan microRNA (miR) array analysis revealed that 18 miRs were upregulated in the SAT of MSL patients. Transfection of human adipose-derived mesenchymal stem cells (hADSCs) with the individual agomirs of these 18 miRs showed that miR-125a-3p and miR-483-5p significantly promoted adipogenesis. A dual-luciferase assay showed that RhoA and ERK1 were the targets of miR-125a-3p and miR-483-5p, respectively. Moreover, transfection of hADSCs with mimics of miR-125a-3p and miR-483-5p resulted in a pronounced decrease of ERK1/2 phosphorylation in the nucleus; conversely, transfection of hADSCs with inhibitors of miR-125a-3p and miR-483-5p led to a significant increase of ERK1/2 phosphorylation in the nucleus. Most importantly, we found that miR-125a-3p and miR-483-5p promoted de novo adipose tissue formation in nude mice. These results demonstrated that miR-125a-3p and miR-483-5p coordinately promoted adipogenesis through suppressing the RhoA/ROCK1/ERK1/2 pathway. Our findings may provide novel strategies for the management and treatment of MSL or obesity.

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mentioning

confidence: 99%

miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis

Chen

Xie

et al. 2015

Sci Rep

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“… 5 - 8 Alcoholic abuse is present in more than 90% of the cases. 9 A decrease in the beta-adrenergic receptors and disturbance in the mitochondrial DNA may be an explication of the pathogenic alcohol mechanism. 10 …”

Section: Discussionmentioning

confidence: 99%

Madelung disease (multiple symmetric lipomatosis)

Maximiano¹,

Gaspar²,

Nakahira³

2018

Autops. Case Rep.

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Madelung disease or multiple symmetric lipomatosis (MSL) is a rare entity among the overgrowth syndromes. It is characterized by painless non-encapsulated and symmetric fatty deposits in the neck, torso, mammary, and abdominal areas, and in the upper and lower limbs. The etiology of the disease is still unknown. Chronic alcohol consumption may play a role in adipocyte hyperplasia in genetically susceptible individuals. Besides the overgrowth of adipose tissue, patients with MSL present features of metabolic syndrome. Patients seek medical attention usually for esthetic reasons. We present the case of a middle-aged man who sought the outpatient clinic complaining of bulging masses in the posterior upper part of the thorax, the occipital area, and the neck. The masses grew over a period of 2 years. The physical examination and imaging study revealed the presence of symmetric lipomatosis. A two-step surgical treatment was undertaken for the excision of the lipomatous tissue. The postoperative outcome was uneventful with satisfactory esthetic results.

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“…MD type II đặc trưng bởi sự tích lũy mỡ vùng bụng và đùi, thường không liên quan đến tình trạng nghiện rượu. MD type III ít gặp hơn, liên quan đến sự tích tụ mỡ ở vùng xương chậu [5], [8]. Tỷ lệ mắc MD rất hiếm và không khó để chẩn đoán theo tiền sử và dấu hiệu thực thể của bệnh nhân.…”

Section: Bàn Luậnunclassified

Surgical treatment of huge lipoma of bilateral submandibular region spread down the neck in a patient with madelung’s disease: rare clinical case report

Nguyen Van,

Hoang Vu,

Vo Khac

2023

JMP

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Madelung disease (MD) is a disease of fat metabolism disorder that causes the formation of lipoma fatty tumors throughout the body. The disease mainly occurs in the Mediterranean population and is very rare in Asians, with a male: female ratio of 15 - 30:1, closely related to alcohol. The treatment of MD primarily is surgical resection of the tumor to management of cosmetic and functional issues. We report a rare clinical case of Madelung disease type I with bilateral submandibular lipoma tumor spreading down the neck affecting neck mobility and aesthetics, who was successfully operated at department of Maxillofacial Surgery, Hue University of Medicine and Pharmacy Hospital. Key words: madelung disease (MD), lipomas, surgical treatment.

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Multiple symmetrical lipomatosis (Madelung’s disease)✰✰Please cite this article as: Ikumi-Shibasaki I, Ikuo-Shibasaki H, Nakamoto TS, Baccan FS, Raposo LS. Multiple symmetrical lipomatosis (Madelung's disease). Braz J Otorhinolaryngol. 2014;80:90–1.

Cited by 9 publications

References 3 publications

miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis

miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis

Madelung disease (multiple symmetric lipomatosis)

Surgical treatment of huge lipoma of bilateral submandibular region spread down the neck in a patient with madelung’s disease: rare clinical case report

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