Variants of papillary thyroid carcinoma: association with histopathological prognostic factors

Girardi, Fábio Muradás; Barra, Marinez Bizarro; Zettler, Cláudio Galleano

doi:10.5935/1808-8694.20130135

Cited by 22 publications

(21 citation statements)

References 17 publications

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“…To date, published data about the importance of LVI for outcomes among patients with PTC have been limited to small, retrospective, single institution studies (Kim et al 2006, Girardi et al 2013. This is the first study to examine the association between LVI and mortality for PTC in a nationwide database and to demonstrate that the presence of tumor LVI is associated with compromised patient survival.…”

Section: Discussionmentioning

confidence: 99%

“…Most studies to date assessing LVI have focused on disease recurrence (Kim et al 2006, Girardi et al 2013. In an analysis of 517 patients with PTC undergoing thyroidectomy at a single institution over 11 years, Girardi and coworkers reported LVI as an important risk factor for disease recurrence, as well as cervical lymph node metastasis (Girardi et al 2013).…”

Section: Discussionmentioning

confidence: 99%

“…In an analysis of 517 patients with PTC undergoing thyroidectomy at a single institution over 11 years, Girardi and coworkers reported LVI as an important risk factor for disease recurrence, as well as cervical lymph node metastasis (Girardi et al 2013). They also demonstrated that LVI was associated with more aggressive histological subtypes of PTC, such as the diffuse sclerosing, tall cell, and solid variants.…”

Section: Discussionmentioning

confidence: 99%

“…Data regarding the impact of lymphovascular invasion (LVI) on patient outcomes in PTC have been limited, based primarily on small, retrospective institutional studies (Kim et al 2006, Girardi et al 2013. One single institution study by Kim et al, including 662 PTC patients, of whom 33 (5%) had LVI, found that there was a significant association between LVI and both lateral cervical lymph node metastases and an increased risk of disease recurrence.…”

Section: Introductionmentioning

confidence: 99%

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Lymphovascular invasion is associated with survival for papillary thyroid cancer

Pontius¹,

Youngwirth²,

Thomas³

et al. 2016

Endocrine-Related Cancer

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Data are limited regarding the association between tumor lymphovascular invasion and survival for patients with papillary thyroid cancer (PTC). This study sought to examine lymphovascular invasion as an independent prognostic factor for patients with PTC undergoing thyroid resection. The National Cancer Data Base (2010-2011) was queried for patients with PTC who underwent total thyroidectomy or lobectomy. Patients were classified into two groups based on the presence/absence of lymphovascular invasion. Demographic, clinical and pathological features were evaluated for all patients. A Cox proportional hazards model was utilized to identify factors associated with survival. Results show that 45,415 patients met inclusion criteria; 11.6% had lymphovascular invasion. Patients with lymphovascular invasion were more likely to have larger tumors (2.8 cm vs 1.5 cm, P < 0.01), metastatic lymph nodes (74.1% vs 32.5%, P < 0.01), and distant metastases (3.0% vs 0.5%, P < 0.01). They were also more likely to receive radioactive iodine (69.3% vs 44.9%, P < 0.01). Unadjusted overall 5-year survival was lower for patients who had tumors with lymphovascular invasion (86.6% vs 94.5%) (log-rank P < 0.01). After adjustment, increasing patient age (HR = 1.06, P < 0.01), male gender (HR = 1.68, P < 0.01), presence of metastatic lymph nodes (HR = 1.77, P < 0.01), distant metastases (HR = 3.49, P < 0.01), and lymphovascular invasion (HR = 1.88, P < 0.01) were associated with compromised survival. For patients with lymphovascular invasion, treatment with RAI was associated with reduced mortality (HR = 0.43, P < 0.01). The presence of lymphovascular invasion among patients with PTC is independently associated with compromised survival. Patients who have PTC with lymphovascular invasion should be considered higher risk, and adjuvant RAI should be more strongly considered.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Lymphovascular invasion is associated with survival for papillary thyroid cancer

Pontius¹,

Youngwirth²,

Thomas³

et al. 2016

Endocrine-Related Cancer

View full text Add to dashboard Cite

show abstract

“…Pathological subtype is another factor affecting prognosis of papillary thyroid cancer. Girardi et al (8) evaluated 517 patients with papillary thyroid cancer in their study, in which papillary microcarcinoma, classical type and follicular subtype accounted for 82.9% of the patients. These three subtypes accounted for 92.7% of the patients in the present study; however, different from this study, follicular subtype was more prevalent than the classical subtype (7).…”

Section: Discussionmentioning

confidence: 99%