Correlation between symptoms and course duration of upper aerodigestive tract cancer at early and advanced stages

Santos, Francis Balduíno Guimarães; Vasconcelos-Raposo, José; Figueiredo, Maria do Carmo Tolentino

doi:10.5935/1808-8694.20130125

Cited by 8 publications

(8 citation statements)

References 23 publications

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“…16 According to Santos et al, malignant lesions were common in males, men being more exposed to carcinogens in tobacco and alcohol which lead to the development of upper aerodigestive tract malignancy. 17 According to Suba, oral and pharyngeal cancers among men and women occur in the ratio 4:1. 18 Oral cancer is the fourth most common cancer in men and the eighth most common cancer in women.…”

Section: Discussionmentioning

confidence: 99%

Anatomical site-wise distribution of upper aerodigestive tract malignancies in a rural population

Shariff

2018

Int J Otorhinolaryngol Head Neck Surg

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Background: Upper aerodigestive tract malignancies constitute approximately 4% of all malignancies. These include cancers of the various sites of the upper aerodigestive tract where malignant lesions can be found such as the nasal cavity, paranasal sinuses, nasopharynx, oral cavity and it's sub-sites, oropharynx, larynx and hypopharynx. Malignancies of these sites are found to be common in people from lower socio-economic strata. Tobacco and alcohol are considered as risk factors for it's development. Methods: A cross-sectional study was conducted in the outpatient section for a period of 1 years 10 months from October 2014 to July 2016. During the study period, 100 cases that were diagnosed as having upper aerodigestive tract malignancy by histopathology were included in the study group. The aim of this study is to determine the epidemiology, clinical features and anatomical site-wise distribution of malignancy in the study group. Results: Oral cavity was the commonest site where malignancy developed in the upper aerodigestive tract followed by the larynx. Malignant disease was more common in males and in the elderly. Majority of the patients who developed malignancy had history of tobacco and alcohol consumption. Conclusions: Oral cavity malignancy is common in rural population, is associated with tobacco chewing and is more common in elderly male.

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Section: Discussionmentioning

confidence: 99%

Anatomical site-wise distribution of upper aerodigestive tract malignancies in a rural population

Shariff

2018

Int J Otorhinolaryngol Head Neck Surg

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“…This was supported by another study that also observed that the carcinoma of aero-digestive tract was more prevalent in the age group of 41 to 60 years (65.6%). 15 The current study group comprised predominantly males. This was observed in other studies which stated that the OSCC have male predominance.…”

Section: Discussionmentioning

confidence: 99%

Correlation of plasma lipid levels and histopathological grading in patients with oral squamous cell carcinoma and its pre-cancerous lesions

Singh

et al. 2018

Int J Otorhinolaryngol Head Neck Surg

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Background: Lower levels of lipid in proliferating tissues and in blood compartments may occur due to ongoing process of oncogenesis. The evidence regarding hypolipidemia as a predisposing factor for malignancy is scarce. Therefore, this study was undertaken to study alteration of plasma lipid levels in patients diagnosed with oral squamous cell carcinoma (OSCC) and its oral pre-cancerous (OPC) lesions and also to compare the plasma lipid profile in different grades of OSCC.Methods: A single centre prospective cross sectional study was carried out among 150 consecutive patients of OSCC and OPC lesions. The diagnosis of all lesions was confirmed histopathologically and grading was also done for each lesion based on degree of differentiation and keratinization of tumour cells. Serum total cholesterol, HDL, TG, LDL was estimated by using semi-automated chemical analyzer. The lipid levels were compared by using unpaired t-test between two strata whereas one way analysis of variance (ANOVA) with Tukey’s post-hoc tests was used among more than two strata. Results: Total cholesterol, TG, HDL, and LDL were significantly reduced in OSCC and OPC groups when compared with the reference values. Serum TC, LDL and HDL levels were found to be decreased with the loss of differentiation in histological grading but with no statistical significance.Conclusions: It can be inferred that there is an inverse relationship between the serum lipid profile values of TC, HDLC, TG, LDL and OSCC as well as OPC patients. The lower serum lipid status may be considered a useful indicator for initial changes occurring in neoplastic cells.

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“…Patients who initially present with advanced cancer usually have multiple symptoms which need to be addressed [66][67][68][69][70].…”

Section: Triggers Versus Automatic Referral For Palliative Carementioning

confidence: 99%

Promoting further use of palliative care in cancer care centers

Davis

Carrino

2016

Expert Review of Quality of Life in Cancer Care

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Palliative care has changed since its inception with Dr Balfour Mount in 1976. It is moving slowly from the care of the dying (which is still an important part of palliative care) and crisis intervention to integrated care with oncology early in the course of advanced cancer. Several studies have demonstrated the advantages to this approach. In this review we will discuss indicators of structure process and outcomes, outcomes to integration, components to successful integration of care and barriers to integrated care. Family financial toxicity related to cancer care is a growing problem that will need to be measured as an outcome to integrated care ARTICLE HISTORY

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Correlation between symptoms and course duration of upper aerodigestive tract cancer at early and advanced stages

Abstract: The results suggest a disease of insidious onset in the early stages and fast course afterwards. The long disease duration - greater than three months, was associated with worsening in general and nutritional states of patients.

Cited by 8 publications

References 23 publications

Anatomical site-wise distribution of upper aerodigestive tract malignancies in a rural population

Anatomical site-wise distribution of upper aerodigestive tract malignancies in a rural population

Correlation of plasma lipid levels and histopathological grading in patients with oral squamous cell carcinoma and its pre-cancerous lesions

Promoting further use of palliative care in cancer care centers

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