Surgical treatment and adjuvant therapies of recurrent respiratory papillomatosis

Abstract

The choice of surgical technique varies among studies, but there is a trend to use the microdebrider. The newer adjuvant therapies, such as cidofovir, quadrivalent vaccine against human papilloma virus and bevacizumab, require further studies.

Is recurrent respiratory papillomatosis a manageable or curable disease?

“…Recurrent respiratory papillomatosis is the most common benign tumor of the larynx that recurs very frequently. It is usually treated surgically with concurrent adjuvant therapies, such as antiviral agents and PDL or a KTP laser . Recurrent respiratory papillomatosis recurs due to the multiple extensibility based on the histological characteristics of the papilloma, as well as the invasiveness and differences in the papilloma clinical course according to the viral subtypes .…”

“…The intralesional injection of cidofovir as adjuvant therapy was not effective for inhibiting recurrence, although many reports have indicated the safety and anticancer effects of cidofovir in various type of tumor cells …”

“…It is usually treated surgically with concurrent adjuvant therapies, such as antiviral agents and PDL or a KTP laser. 1,[5][6][7][8]10 Recurrent respiratory papillomatosis recurs due to the multiple extensibility based on the histological characteristics of the papilloma, as well as the invasiveness and differences in the papilloma clinical course according to the viral subtypes. 11 Therefore, RRP is considered a manageable disease rather than a curable one.…”

“…The intralesional injection of cidofovir as adjuvant therapy was not effective for inhibiting recurrence, although many reports have indicated the safety and anticancer effects of cidofovir in various type of tumor cells. 7,10,15 CONCLUSION Recurrent respiratory papillomatosis is an intractable disease that is very difficult to cure. Although various adjuvant and combined concurrent therapies have been studied, RRP is a benign laryngeal tumor that is very difficult to cure completely because of the histopathological characteristics of papilloma and the complexity of laryngeal anatomy.…”

Dysphonia as a sign of HPV laryngeal infection: a case report

“…The injury is typically diagnosed as benign squamous papilloma and can lead to discomfort in speaking, affecting mainly the vocal folds, epiglottis and vestibular folds, with possible recurrence [9–11]. …”