Is there any effect of coenzyme Q10 on prevention of myringosclerosis? Experimental study with rats

Aydoğan, Filiz; Aydın, Esra; Taştan, Eren; Akgedik, Şükran; Tekeli, Ahmet; Üstün, Hüseyin

doi:10.5935/1808-8694.20130053

Cited by 6 publications

(1 citation statement)

References 17 publications

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“…It is characterized histologically by an increase in collagenous fibers, decreased vascularization and cell formation hyalinization calcification and degeneration of the collagen layer. 1 , 2 TS is usually identified as white chalky patches either in the middle ear mucosa or in the tympanic membrane (TM). At the beginning of the pathology it consists of cheese-like masses of tympanosclerotic material and by the time similar to bone it gets harder.…”

Section: Introductionmentioning

confidence: 99%

The effect of melatonin and vitamin C treatment on the experimentally induced tympanosclerosis: study in rats

Koç

Kiyici

Toker

et al. 2017

Brazilian Journal of Otorhinolaryngology

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Section: Introductionmentioning

confidence: 99%

The effect of melatonin and vitamin C treatment on the experimentally induced tympanosclerosis: study in rats

Koç

Kiyici

Toker

et al. 2017

Brazilian Journal of Otorhinolaryngology

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Formulation development and in vivo hepatoprotective activity of self nanoemulsifying drug delivery system of antioxidant coenzyme Q10

Agrawal¹,

Kumar²,

Gide³

2014

Arch. Pharm. Res.

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Coenzyme Q (CQ) is known as an endogenous cellular antioxidant, naturally found in every cell of the human body and plays an important role in maintaining human health. It is widely used as a nutritional supplement and pharmaceutical drug for various disorders like diabetes mellitus, carcinomas, neurodegenerative disorders etc. However, CQ is practically insoluble even in the presence of 5 % sodium lauryl sulfate in water and poorly absorbed from the gastrointestinal tract. The present research is aimed to formulate and evaluate self nanoemulsifying drug delivery system (SNEDDS) of CQ primarily to improve its aqueous solubility, dissolution velocity as well as hepatoprotective activity and thus enhancing its nutraceutical and pharmaceutical values. Robustness to dilution, thermodynamic stability study, droplet size analysis and drug release were adopted to optimize liquid SNEDDS. Droplet size of the SNEDDS was found to be size less than 200 nm and appeared round in shape without aggregation under transmission electron microscopy examination. Liquid SNEDDS were adsorbed on porous carrier to get solid SNEDDS (S-SNEDDS). S-SNEDDS gave rapid (>90 %) drug release within 30 min while pure drug was not practically dissolved within 1 h. In vivo hepatoprotective activity showed that S-SNEDDS achieved the most liver protection as compared to the pure drug. Further S-SNEDDS was successfully converted to self nanoemulsifying mouth dissolving tablet. The enhanced solubility, dissolution velocity as well as hepatoprotective activity of CQ, unravels the potential of S-SNEDDS as suitable carrier for enhancing nutraceutical and pharmaceutical values of CQ.

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Inhibitory effect of N-acetyl cysteine and ascorbic acid on the development of myringosclerosis: An experimental study

Dündar

İnan

Muluk

et al. 2014

International Journal of Pediatric Otorhinolaryngology

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Is there any effect of coenzyme Q10 on prevention of myringosclerosis? Experimental study with rats

Abstract: Oral administration of coenzyme Q10 did not reduce myringosclerosis formation in myringotomized rats.

Cited by 6 publications

References 17 publications

The effect of melatonin and vitamin C treatment on the experimentally induced tympanosclerosis: study in rats

The effect of melatonin and vitamin C treatment on the experimentally induced tympanosclerosis: study in rats

Formulation development and in vivo hepatoprotective activity of self nanoemulsifying drug delivery system of antioxidant coenzyme Q10

Inhibitory effect of N-acetyl cysteine and ascorbic acid on the development of myringosclerosis: An experimental study

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