Head and neck cancer: causes, prevention and treatment

Galbiatti, Ana Lívia Silva; Padovani-Junior, João Armando; Maníglia, José Victor; Rodrigues, Cléa Dometilde Soares; Pavarino, Érika Cristina; Goloni-Bertollo, Eny Maria

doi:10.5935/1808-8694.20130041

Cited by 135 publications

(161 citation statements)

References 49 publications

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“…This measure of agreement has as maximum value one, which represents total agreement. Close values and even below zero indicate no agreement (18) .…”

Section: Analysis Of Results and Statisticsmentioning

confidence: 99%

“…In addition, it is usual that the demand for specific and complex care tends to increase during the treatment of patients with head and neck cancers, depending on the treatments used and the evolution of the disease itself (18) . Therefore, the transmission of health information is most effective when its contents are specifically designed for a person or a population group and when the message is well delimited, highlighting the benefits (gains) and costs (losses) associated with the behaviors and decision-making.…”

Section: Discussionmentioning

confidence: 99%

“…Further clarification on the different types of treatment may assist in more conscious decision-making about the conditions, risks and benefits of each therapeutic modality (18)(19)(21)(22) .…”

Section: -Surgical Treatment -Radiotherapy -Cytotoxic Chemotherapymentioning

confidence: 99%

“…To inform the patient, family member and / or caregiver about cancer and head and neck cancer, with an approach that enables them to understand their disease, clarifying the implications and consequences of the established diagnosis (18,(21)(22) .…”

Section: Selected Content Justification Presentationmentioning

confidence: 99%

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Construction and validation of clinical contents for development of learning objects

2018

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Objective: to describe the process of construction and validation of clinical contents for health learning objects, aimed at patients in the treatment of head and neck cancer. Method: descriptive, methodological study. The development of the script and the storyboard were based on scientifi c evidence and submitted to the appreciation of specialists for validation of content. The agreement index was checked quantitatively and the suggestions were qualitatively evaluated. Results: The items described in the roadmap were approved by 99% of expert experts. The suggestions for adjustments were inserted in their entirety in the fi nal version. The free-marginal kappa statistical test, for multiple evaluators, presented value equal to 0.68%, granting a substantial agreement. Conclusion: The steps taken in the construction and validation of the content for the production of educational material for patients with head and neck cancer were adequate, relevant and suitable for use in other subjects. Descriptors: Nursing; Nursing Care; Validation Studies; Health Education; Head and Neck Neoplasms. RESUMO Objetivo: descrever o processo de construção e validação de conteúdos clínicos para objetos de aprendizagem em saúde, direcionados aos pacientes em tratamento do câncer de cabeça e pescoço. Método: estudo descritivo, metodológico. O desenvolvimento do roteiro e o storyboard foram fundamentados em evidências científi cas e submetidos à apreciação de especialistas para validação de conteúdo. Verifi cou-se o índice de concordância, quantitativamente, e avaliaram-se qualitativamente as sugestões. Resultados: os itens descritos no roteiro foram aprovados por 99% dos especialistas peritos. As sugestões de ajustes foram inseridas, em sua totalidade, na versão fi nal. O teste estatístico kappa free-marginal, para múltiplos avaliadores, apresentou valor igual a 0,68%, conferindo uma concordância substancial. Conclusão: os passos adotados no percurso de construção e validação do conteúdo para produção de material educativo destinado aos pacientes com câncer de cabeça e pescoço mostraram-se adequados, relevantes e passíveis de serem utilizados em outras temáticas. Descritores: Enfermagem; Cuidados de Enfermagem; Estudos de Validação; Educação em Saúde; Neoplasia de Cabeça e Pescoço. RESUMENObjetivo: describir el proceso de construcción y validación de contenidos clínicos para objetos de aprendizaje en salud, direccionado a los pacientes en tratamiento de cáncer de cabeza y cuello. Método: estudio descriptivo, metodológico. El desarrollo del guion y storyboard fueron fundamentados en evidencias científi cas, y sometidos a la apreciación de especialistas para validación de contenido. Se verifi có el índice de concordancia, cuantitativamente, y se evaluaron cualitativamente las sugerencias. Resultados: los ítems descriptos en el guion fueron aprobados por 99% de los especialistas peritos. Las sugerencias de ajustes fueron inseridas en su totalidad en la versión fi nal. El test estadístico kappa free-marginal para múltiplos evalu...

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“…This measure of agreement has as maximum value one, which represents total agreement. Close values and even below zero indicate no agreement (18) .…”

Section: Analysis Of Results and Statisticsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: -Surgical Treatment -Radiotherapy -Cytotoxic Chemotherapymentioning

confidence: 99%

Section: Selected Content Justification Presentationmentioning

confidence: 99%

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Construction and validation of clinical contents for development of learning objects

2018

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“…The classical risk factors of HNSCC include tobacco, alcohol, and human papillomavirus (HPV) (Farris et al, 2013;Galbiatti et al, 2013). Nevertheless, only some smokers, alcohol users, and HPV-infected individuals develop HNSCC, suggesting that the genetic susceptibility of individuals is a possible influencing factor (Liang et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Association Between p53 Arg72Pro Polymorphism and the Risk of Human Papillomavirus-related Head and Neck Squamous Cell Carcinoma: A Meta-analysis

Xia

Zeng²,

Li³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Epidermal growth factor receptor (EGFR) involvement in epithelial‐derived cancers and its current antibody‐based immunotherapies

London

Gallo

2020

Cell Biology International

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The epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that is part of the family of tyrosine kinase receptors. The binding of EGFR to its cognate ligands leads to its autophosphorylation and subsequent activation of the signal transduction pathways involved in regulating cellular proliferation, differentiation, and survival. Accordingly, this receptor carries out both redundant and restricted functions in the germline development of mammals and in the maintenance of various adult tissues. Correspondingly, the loss of EGFR regulation results in many human diseases, with the most notable cancer. This receptor is overexpressed and/or mutated in multiple epithelial-derived tumors, and associated with poor prognosis and survival in cancer patients. Here, we discuss in detail the role of EGFR in specific epithelial-derived cancer pathologies; these include lung cancer, colorectal cancer, and squamous cell carcinomas. The development of multiple anticancer agents against EGFR diminished the progression and metastasis of tumors. Some of the most versatile therapeutic anti-EGFR agents include the monoclonal antibodies (mAbs), demonstrating success in clinical settings when used in combination with cytotoxic treatments, such as chemotherapy and/or radiation. We thus discuss the development and application of two of the most notable therapeutic mAbs, cetuximab, and panitumumab, currently utilized in various EGFR-related epithelial cancers.

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Head and neck cancer: causes, prevention and treatment

Abstract: Additional research is needed for a more thorough understanding of the development of head and neck carcinomas and to shed light on new ways to improve therapeutic approaches and interventions.

Cited by 135 publications

References 49 publications

Construction and validation of clinical contents for development of learning objects

Construction and validation of clinical contents for development of learning objects

Association Between p53 Arg72Pro Polymorphism and the Risk of Human Papillomavirus-related Head and Neck Squamous Cell Carcinoma: A Meta-analysis

Epidermal growth factor receptor (EGFR) involvement in epithelial‐derived cancers and its current antibody‐based immunotherapies

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