Ear injury as the only manifestation of amyloidosis

Domingos, Catia Rodrigues; Sousa, Rubiana Ferreira; Becker, Helena Maria Gonçalves; Crosara, Paulo Fernando Tormin Borges; Guimarães, Roberto Eustáquio Santos

doi:10.5935/1808-8694.20130020

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…In the head and neck, amyloidosis occurs in 19% of cases [38] and can affect skin [5,6], oral cavity [7,8], nasal cavity [9,10,39], pharinx [11,40], parotid gland [2], ear [12,13] and larynx [3,4].…”

Section: Discussion/literature Reviewmentioning

confidence: 99%

“…Regarding Parotid only two cases were found in literature review [2,49]. Moreover, ear amyloidosis case reports [12,13,50] emphasize that ear involvement relates to localized form, it´s usually associated with lower morbidity and, most of times, there is possibility of clinical treatment.…”

Section: Discussion/literature Reviewmentioning

confidence: 99%

“…In this universe, there is preferential involvement of upper airways, being the larynx the most affected organ [3,4]. Other affected sites are: skin [5,6], oral cavity [7,8], nasal cavity [9,10], pharynx [11], parotid gland [2] and ear [12,13]. No reports on multiple sites involvement in head and neck were found in literature review.…”

Section: Introductionmentioning

confidence: 99%

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Disseminated Amyloidosis in Head and Neck - Literature Review and Discussion of an Unusual Case

Farias¹

2016

GJO

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Primary amyloidosis of head and neck is an extremely rare event and there are few cases reported in the literature. Amyloidosis is a group of diseases that have as etiology the extracellular proteins deposition in many organs, causing architectural and functional damage to them. This article´s objective is to report a case of primary amyloidosis localized in skin, tongue, parotid and upper airways simultaneously in one patient and do a literature review on the topic. Patient W.K.Y. 72 years-old, from China, living in Brazil for 6 months, come out with vesicles in the head and neck about one year ago. The disease had been spreading to face and neck skin as well as lips, oral mucosa and tongue. Because of oral feeding impairment and dyspnoea, the patient was taken to an emergency service, where clinical investigation started. As previous treatment, It was reported the use of Chinese medicine, acupuncture and herbs. Patient had no diabetes, hypertension, Alzheimer's disease or nephropathy. Also, he had no family history of any degenerative or infectious disease. Patient diagnosis was: primary amyloidosis with secondary rheumatoid component. For treatment, a prednisolone pulse therapy associated with colchicine was elected, causing regression edema of tongue, suprahyoid region, lips and parotid glands, likewise about 50% of skin neck vesicles disappeared Head and neck Amyloidosis occurs in 19% of cases and may affect the skin, ear, nasal cavity, oral cavity, parotid, pharynx and larynx. Larynx is the most commonly affected organ in this region, accounting for the largest number of case reports and case series in the literature, with treatment and well-established management. The diagnosis is made based on histopathologycal examination and biochemical characterization of amyloid type. The treatment is based on the surgical resection with variable recurrence rates, according to affected organ.

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Section: Discussion/literature Reviewmentioning

confidence: 99%

Section: Discussion/literature Reviewmentioning

confidence: 99%

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Disseminated Amyloidosis in Head and Neck - Literature Review and Discussion of an Unusual Case

Farias¹

2016

GJO

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The evaluation of cochlear functions in Familial Mediterranean Fever

Eryılmaz

Yücel²,

Cüre

et al. 2016

Eur Arch Otorhinolaryngol

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Familial Mediterranean Fever (FMF) is a progressive disease characterized by chronic inflammation, which also has negative effects on cochlear functions and hearing levels. We investigated whether the cochlear functions and hearing levels of FMF patients were different than healthy controls and also evaluated the relationship of hearing levels with the age at diagnosis, duration without treatment, and inflammation and lipid parameters in this study. A total of 60 patients diagnosed with FMF and 48 age, gender and body mass index (BMI)-matched healthy controls were included in the study. The hemogram, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and lipid parameters of the subjects were studied and they all underwent pure tone audiometry and Transient evoked otoacoustic emission tests after an otologic examination. The hearing levels of the FMF group were significantly higher than those of the control group. The TEOAE signal/noise (S/N) ratios were similar in both groups. A positive relationship was present between the audiometric test results and the age, BMI, low-density lipoprotein and triglyceride levels and a negative relationship with the high-density lipoprotein levels. A negative relationship was present between the TEOAE S/N ratios and the age of the patients, duration without treatment, lipid parameters, inflammation markers and the creatinine level. FMF patients are exposed to chronic inflammation and this can influence their hearing levels. The age at diagnosis, duration without treatment, chronic inflammation, unfavorable lipid parameters, and obesity can affect hearing tests negatively.

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