“…In more advanced forms (Stage V), total destruction of the columella may occur and may drop, thus transforming the nasal cavity into a similar cloaca and sometimes there is perforation of the dorsum of the nasal pyramid [17]. For some researchers, the specific destruction of the nasal cartilage could also indicate an autoimmune reaction that would explain why some patients undergo severe tissue destruction and others only present mucosal involvement years later [21]. In some cases there may be total destruction of the anterior septum, only the entire columella remaining, with the nose being sealed.…”