Fungal Endocarditis

Yuan, Shi-Min

doi:10.5935/1678-9741.20160026

Cited by 44 publications

(60 citation statements)

References 34 publications

(43 reference statements)

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“…Risk factors for ocular and cardiac involvement due to invasive Candida infections include diseases leading to immunodeficiency [diabetes mellitus (DM), renal failure, malignancy], intravenous drug dependence, long-term use of multiple broad-spectrum antibiotics, long-term central venous catheterization, parenteral nutrition, previous major abdominal or cardiovascular surgery, presence of a prosthetic cardiac valve, long-term steroid or immunosuppressive therapy (6,21,25,26,31,32). However, the correct antifungal therapy at an appropriate time can prevent the development of complications such as endophthalmitis and endocarditis in patients with candidemia (33,34).…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Cardiac and Ocular Findings in Patients with Invasive Candida Infection in Intensive Care Unit

Tomak¹,

Palabıyık²,

Öztatar³

et al. 2019

Yoğun Bakım Derg

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Introduction: Invasive candidiasis (IC) is a common opportunistic infection in intensive care units (ICUs). IC may cause endocarditis by spreading hematogenously to the heart valves and endocardium or may spread to intraocular tissues and cause endophthalmitis and chorioretinitis. Therefore, echocardiography and an ocular examination should be performed in patients with IC. These complications increase morbidity and mortality. The early diagnosis and treatment of IC are important to reduce these complications. The aim of this study was to determine the prevalence of cardiac and ocular involvement in patients with IC in the ICU. Materials and Methods: This study was performed retrospectively between January 2015 and December 2017 in the 20-bed ICU. The archive files of patients diagnosed with IC were analyzed. By reviewing the consultation reports of Cardiology and Ophthalmology clinics, cardiac and ocular findings were reported. Results: Invasive Candidiasis was detected in 44 of 1746 patients who were admitted to the ICU. While the ratio of IC was 25.2 in 1000 patients, the IC rate was 2.02 in 1000 patient days. Of these patients, 41 (93.2%) had central venous catheter-related bloodstream infection, and three (6.8%) of them had urinary tract infection. The most common agents were C. albicans (n = 20, 42.6%) and C. parapsilosis (n = 20, 42.6%). The others were C. tropicalis (n = 4, 8.5%), unspecified Candida spp. (n = 2, 4.2%), and C. glabrata (n = 1, 2.1%). None of the patients had signs of cardiac involvement, such as endocardial vegetation, and signs of ocular involvement, such as chorioretinitis, endophthalmitis, and vitritis. Conclusion: In our study, we did not detect cardiac and ocular involvement in patients with IC. We believe that larger-scale prospective studies are needed to determine the prevalence of these complications in the ICU.

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Section: Discussionmentioning

confidence: 99%

The Prevalence of Cardiac and Ocular Findings in Patients with Invasive Candida Infection in Intensive Care Unit

Tomak¹,

Palabıyık²,

Öztatar³

et al. 2019

Yoğun Bakım Derg

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“…The patient had a satisfactory outcome after aortic valve replacement (Pilar, 2010). Fungal endocarditis and mycobacterial endocarditis are also causative sources of FUO (Yuan, 2015a(Yuan, , 2016. Yuan (2016) summarized the clinical features of fungal endocarditis, and found all patients presented with fever and 2 of them had FUO, eventually requiring surgical treatment.…”

Section: Infective Endocarditis (Ie)mentioning

confidence: 99%

“…Fungal endocarditis and mycobacterial endocarditis are also causative sources of FUO (Yuan, 2015a(Yuan, , 2016. Yuan (2016) summarized the clinical features of fungal endocarditis, and found all patients presented with fever and 2 of them had FUO, eventually requiring surgical treatment. Additionally, Yuan (2015a) described mycobacterial endocarditis, noting 76.1% of patients had fever with a mean body temperature of 38.9 • C and a mean CRP of 6.8 mg/dL, and 2 of them had FUO.…”

Section: Infective Endocarditis (Ie)mentioning

confidence: 99%

Cardiac and vascular causes of persistent fever: A systematic review

Yuan

2019

Reviews in Cardiovascular Medicine

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“…Особое внимание следует уделить ИЭ, вызываемому грибами родов Candida и Aspergillus [35,55]. В этом случае смертность чрезвычайно высока (50 % [56]), а клинические проявления очень сходны с таковыми при бактериальном ИЭ.…”

Section: диагностикаunclassified

“…Это может затруднить диагностику и, как следствие, своевременную адекватную терапию антимикотиками. В группу риска попадают пациенты, получающие парентеральное питание, иммуносупрессивные препараты, перенесшие имплантацию или реимплантацию протезного клапана сердца либо установку венозного катетера [55].…”

Section: диагностикаunclassified

Infective Endocarditis Causing Native and Prosthetic Heart Valve Dysfunction

et al. 2019

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Infective endocarditis (IE) is the disease that has high inhospital mortality. Heart valves dysfunction – both native and prosthetic – is the primary IE complication requiring a surgical intervention. The IE causes and its course have been discussed in this review. In particular, the role of concomitant infectious foci in the formation and development of IE have been considered, the mechanisms of mutual transition of subacute and acute clinical forms have been described. Modern diagnostic principles and methods based on the Duke criteria system have been mentioned, as well as the difficulties that follow the patient’s clinical status evaluation. The normobiotic microbiota participation, as well as the possibilities for their identification using blood culture and PCR technique, have been closely reviewed. According to modern researches and publications, there have been made the conclusion about the contribution of obligate anaerobic bacteria, fungi and viruses to the development of endocarditis. There have been described the hypothesis about the presumptive strategy for the cardiac dysfunction formation as a result of the IE causative agents cells metabolic activity based on a literature data analysis in the article: vegetation formed by Staphylococcus aureus can lead to the heart valve stenosis, and the influence of hyaluronidases, collagenases on a heart valve structure can lead to regurgitation. The pathogens cells ability to avoid the human immune system response is caused by the biofilms, fibrin vegetations formation and the enzymes production – cytotoxins (streptolysins, leukocidin, etc.). It has been suggested that the mediators of inflammation and leukocyte cells participate in the destruction of native and prosthetic tissues due to an IE pathogens inaccessibility for immunocompetent cells.

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Fungal Endocarditis

Cited by 44 publications

References 34 publications

The Prevalence of Cardiac and Ocular Findings in Patients with Invasive Candida Infection in Intensive Care Unit

The Prevalence of Cardiac and Ocular Findings in Patients with Invasive Candida Infection in Intensive Care Unit

Cardiac and vascular causes of persistent fever: A systematic review

Infective Endocarditis Causing Native and Prosthetic Heart Valve Dysfunction

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