Association of angiotensin converting enzyme genotype insertion/deletion polymorphism and saphenous vein graft atherosclerosis in Iranian patients

Zeinali, Neda; Hashemi, Mohammad; Mirmohammadsadeghi, Mohsen; Mirmohammad-Sadeghi, Hamid; Eskandari, Nahid; Sabzghabaee, Ali Mohammad

doi:10.5935/1678-9741.20150069

Cited by 2 publications

(3 citation statements)

References 34 publications

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“…The presence (insertion) or absence (deletion) of an Alu repetitive element (287-bp repeat sequence) in intron 16 results in I and D alleles, respectively [92]. This common polymorphism accounts for 47% of variations within ACE gene [94]. The results of the current study showed that DD genotype could be a considerable risk factor for CAD susceptibility, particularly in females.…”

Section: Discussionmentioning

confidence: 76%

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Atherosclerotic and thrombotic genetic and environmental determinants in Egyptian coronary artery disease patients: a pilot study

Fawzy

Toraih

Aly

et al. 2017

BMC Cardiovasc Disord

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BackgroundCoronary artery disease (CAD) is the leading cause of morbidity and mortality worldwide. Multiple genetic variants in combination with various environmental risk factors have been implicated. This study aimed to investigate the association of twelve thrombotic and atherosclerotic gene variants in combination with other environmental risk factors with CAD risk in a preliminary sample of Egyptian CAD patients.MethodsTwenty three consecutive CAD patients undergoing diagnostic coronary angiography and 34 unrelated controls, have been enrolled in the study. Genotyping was based on polymerase chain reaction and reverse multiplex hybridization. Five genetic association models were tested. Data distribution and variance homogeneity have been checked by Shapiro-Wilk test and Levene test, respectively; then the appropriate comparison test was applied. Spearman’s rank correlation coefficient was used for correlation analysis and logistic regression has been performed to adjust for significant risk factors. Clustering the study participants according to gene-gene and gene-environment interaction has been done by Detrended Correspondence Analysis (DCA).ResultsThe univariate analysis indicated that the five variants; rs1800595 (FVR2; factor 5), rs1801133 (MTHFR; 5,10-methylenetetrahydrofolate reductase), rs5918 (HPA-1; human platelet antigen 1), rs1799752 (ACE; angiotensin-converting enzyme), and rs7412 and rs429358 (ApoE; apolipoprotein E) were significantly associated with CAD susceptibility under different genetic models. Multivariate analysis revealed clustering of the study population into three patient groups (P) and one control group. FVR2 was the most variant associated with CAD patients, combined with the factor V Leiden (FVL) variant in P1 cluster and with both ACE and MTHFR 667C > T in P2. Whereas, P3 was mostly affected by both MTHFR 667C > T and FXIII (factor 13) V89L mutations. When combined with traditional risk factors, P1 was mostly affected by dyslipidemia, smoking and hypertension, while P2 was mostly affected by their fasting blood sugar levels and ApoE variant.ConclusionsTaken together, these preliminary results could have predictive value to be applied in refining a risk profile for our CAD patients, in order to implement early preventive interventions including specific antithrombotic therapy. Further large scale and follow-up studies are highly recommended to confirm the study findings.Electronic supplementary materialThe online version of this article (doi:10.1186/s12872-016-0456-3) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 76%

“…One of the most popular genetic risk factors in CAD is the ACE insertion/deletion (rs1799752) polymorphism [94]. The ACE gene is located on chromosome 17q23.3 with 26 exons and 25 introns spreading over about 2 Kb [95].…”

Section: Discussionmentioning

confidence: 99%

Atherosclerotic and thrombotic genetic and environmental determinants in Egyptian coronary artery disease patients: a pilot study

Fawzy

Toraih

Aly

et al. 2017

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

“…Previously, in the Iranian population, it has been shown that the D allele is associated with cardiovascular dysfunction [43], and left ventricular hypertrophy (LVH) [44]. Moreover, the reports about Iranian subjects showing the association of II genotype with severity of vein graft atherosclerosis [45], the independent association of DD polymorphism with hypertension in the diabetic population [42], further add to the confusion. All of which suggest the role of genetic factors in cardiac function.…”

Section: Discussionmentioning

confidence: 99%

Association of ACE gene polymorphism with cardiovascular determinants of trained and untrained Iranian men

Falahati

Arazi

2019

Genes and Environ

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Background The insertion (I) rather than deletion (D) of human angiotensin converting enzyme gene (ACE) is associated with lower circulating ACE activity and with endurance performance among Caucasians. The frequency of the ACE gene I/D allele in Iranian sample seems to be more similar to the Caucasians. To assess the possible relationship between I/D polymorphism of ACE gene with athletic status and selected cardiovascular indices and VO 2max in an Iranian population, DNA samples were obtained from 57 trained and untrained men, with soccer as their main training modality. Genotyping for ACE I/D polymorphism was performed using polymerase chain reaction. VO 2max was determined by an incremental test to volitional exhaustion on a motorized treadmill. Results I/D genotype was neither associated with elite athlete status nor with VO 2max , resting heart rate, systolic and diastolic blood pressure. There was no interaction effect of training statue x ACE genotype for each of the examined indices. Conclusions ACE gene variation was not a determinant of cardiovascular function and VO 2max in either trained or untrained Iranian participating in soccer. The absence of an association between either I/D genotype and elite Iranian athlete status and better cardiovascular function also suggests that the ACE gene does not contribute significantly to the phenomenal success of Iranian soccer players.

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Association of angiotensin converting enzyme genotype insertion/deletion polymorphism and saphenous vein graft atherosclerosis in Iranian patients

Cited by 2 publications

References 34 publications

Atherosclerotic and thrombotic genetic and environmental determinants in Egyptian coronary artery disease patients: a pilot study

Atherosclerotic and thrombotic genetic and environmental determinants in Egyptian coronary artery disease patients: a pilot study

Association of ACE gene polymorphism with cardiovascular determinants of trained and untrained Iranian men

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