Yellow fever: laboratorial diagnosis and clinical manifestations

Xavier, Analúcia Rampazzo; Freitas, Gabriela Silva; Santos, Caroline Ferreira dos; Januzzi, Werlley A.; Lacerda, Gilmar S.; Carvalho, Edimilson R. M.; Kanaan, Salim

doi:10.5935/1676-2444.20180050

Cited by 3 publications

(3 citation statements)

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“…Clinical manifestation in humans varies from mild undifferentiated febrile illness to severe disease and occurs in two phases [67]. The incubation period for YFV varies from 3 to 6 days but sometimes may go up to 14 days [47].…”

Section: Viruses Previously Involved In Disease Outbreaks In Ugandamentioning

confidence: 99%

Mosquito-borne arboviruses in Uganda: history, transmission and burden

Mayanja

Mwiine

Lutwama

et al. 2021

Journal of General Virology

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Mosquito-transmitted arboviruses constitute a large proportion of emerging infectious diseases that are both a public health problem and a threat to animal populations. Many such viruses were identified in East Africa, a region where they remain important and from where new arboviruses may emerge. We set out to describe and review the relevant mosquito-borne viruses that have been identified specifically in Uganda. We focused on the discovery, burden, mode of transmission, animal hosts and clinical manifestation of those previously involved in disease outbreaks. A search for mosquito-borne arboviruses detected in Uganda was conducted using search terms ‘Arboviruses in Uganda’ and ‘Mosquitoes and Viruses in Uganda’ in PubMed and Google Scholar in 2020. Twenty-four mosquito-borne viruses from different animal hosts, humans and mosquitoes were documented. The majority of these were from family Peribunyaviridae, followed by Flaviviridae, Togaviridae, Phenuiviridae and only one each from family Rhabdoviridae and Reoviridae. Sixteen (66.7 %) of the viruses were associated with febrile illnesses. Ten (41.7 %) of them were first described locally in Uganda. Six of these are a public threat as they have been previously associated with disease outbreaks either within or outside Uganda. Historically, there is a high burden and endemicity of arboviruses in Uganda. Given the many diverse mosquito species known in the country, there is also a likelihood of many undescribed mosquito-borne viruses. New generation diagnostic platforms have great potential to identify new viruses. Indeed, four novel viruses, two of which were from humans (Ntwetwe and Nyangole viruses) and two from mosquitoes (Kibale and Mburo viruses) including the 2010 yellow fever virus (YFV) outbreak were identified in the last decade using next generation sequencing. Given the unbiased approach of detection of viruses by this technology, its use will undoubtedly be critically important in the characterization of mosquito viromes which in turn will inform other diagnostic efforts.

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Section: Viruses Previously Involved In Disease Outbreaks In Ugandamentioning

confidence: 99%

Mosquito-borne arboviruses in Uganda: history, transmission and burden

Mayanja

Mwiine

Lutwama

et al. 2021

Journal of General Virology

View full text Add to dashboard Cite

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“…Um dado clínico que pode aparecer é o chamado sinal de Faget (bradicardia acompanhada de febre elevada), entretanto, não pode ser considerado um achado específico da doença. Devemos destacar, ainda, a possibilidade de quadros assintomáticos ou oligossintomáticos, assim como o avanço da fase infecciosa diretamente para a fase toxêmica, sem passar pela etapa de remissão (Xavier et. al, 2018).…”

Section: Manifestações Clínicasunclassified

Estudos Multidisciplinares Sobre Saúde Da Criança E Do Adolescente

SOUSA¹,

BARBOSA²,

MACÊDO³

et al. 2023

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Todos os trabalhos foram avaliados pelo corpo editorial do 1º Congresso Brasileiro de Saúde da Criança e do Adolescente. O evento foi realizado de forma remota, nos dias 16, 17 e 18 de dezembro de 2022, sendo promovido pelo Instituto Academic (CNPJ: 42.698.982/0001-87). O congresso contou com a participação de vários palestrantes renomados que discutiram temáticas relevantes sobre o cuidado à saúde da criança e adolescente. O objetivo do evento foi de promover a educação, capacitação, treinamento e atualização multidisciplinar na área da saúde da criança e do adolescente, sendo destinado a discentes, docentes, profissionais de saúde e demais interessados pela discussão da temática. O e-book é composto por dezenas de estudos que abordam assuntos sobre a saúde da criança e do adolescente. Os trabalhos são frutos de pesquisas de autores de vários estados do Brasil.

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“…During the infection phase, the virus multiplies and circulates within the blood. The patient may experience non-specific symptoms such as fever confused with malaria, typhoid or viral hepatitis [66]. When the infection stage enters the intoxication phase, the virus leaves the blood and replicates in the liver, spleen, heart and lymph nodes.…”

Section: Viruses Previously Involved In Disease Outbreaks In Ugandamentioning

confidence: 99%

Mosquito-borne arboviruses in Uganda: history, transmission and burden

Mayanja

Mwiine

Lutwama

et al. 2021

Journal of General Virology

View full text Add to dashboard Cite

Mosquito-transmitted arboviruses constitute a large proportion of emerging infectious diseases that are both a public health problem and a threat to animal populations. Many such viruses were identified in East Africa, a region where they remain important and from where new arboviruses may emerge. We set out to describe and review the relevant mosquito-borne viruses that have been identified specifically in Uganda. We focused on the discovery, burden, mode of transmission, animal hosts and clinical manifestation of those previously involved in disease outbreaks. A search for mosquito-borne arboviruses detected in Uganda was conducted using search terms ‘Arboviruses in Uganda’ and ‘Mosquitoes and Viruses in Uganda’ in PubMed and Google Scholar in 2020. Twenty-four mosquito-borne viruses from different animal hosts, humans and mosquitoes were documented. The majority of these were from family Peribunyaviridae, followed by Flaviviridae, Togaviridae, Phenuiviridae and only one each from family Rhabdoviridae and Reoviridae. Sixteen (66.7%) of the viruses were associated with febrile illnesses. Ten (41.7%) of them were first described locally in Uganda. Six of these are a public threat as they have been previously associated with disease outbreaks either within or outside Uganda. Historically, there is a high burden and endemicity of arboviruses in Uganda. Given the many diverse mosquito species known in the country, there is also a likelihood of many undescribed mosquito-borne viruses. Next generation diagnostic platforms have great potential to identify new viruses. Indeed, four novel viruses, two of which were from humans (Ntwetwe and Nyangole viruses) and two from mosquitoes (Kibale and Mburo viruses) were identified in the last decade using next generation sequencing. Given the unbiased approach of detection of viruses by this technology, its use will undoubtedly be critically important in the characterization of mosquito viromes which in turn will inform other diagnostic efforts.

show abstract

Yellow fever: laboratorial diagnosis and clinical manifestations

Cited by 3 publications

References 0 publications

Mosquito-borne arboviruses in Uganda: history, transmission and burden

Mosquito-borne arboviruses in Uganda: history, transmission and burden

Estudos Multidisciplinares Sobre Saúde Da Criança E Do Adolescente

Mosquito-borne arboviruses in Uganda: history, transmission and burden

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