Transference of CALIPER total alkaline phosphatase reference interval to a
            Brazilian pediatric population

Slhessarenko, Natasha; Andriolo, Adagmar

doi:10.5935/1676-2444.20180035

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10 For alkaline phosphatase, reference values found in the CALIPER project (Canadian Laboratory Initiative in Pediatric Reference Intervals, https:// caliper.research.sickkids.ca/#/) were accepted in children and adolescents, whose reference intervals were transferred to the Brazilian population by Fontes et al in 2018. 11 A formal sample size calculation was not performed since the plan was to study all subjects in the population of interest. As it was a case-series, observational study, descriptive analysis was used to characterize the studied population.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of renal replacement therapy in children and adolescents in the state of Amazonas, Brazil

Schramm

Facincani

Carmona

2022

Rev. paul. pediatr.

View full text Add to dashboard Cite

Objective: To describe the characteristics of stage-5 chronic kidney disease (CKD) children and adolescents undergoing renal replacement therapy (RRT) in Amazonas, Brazil, estimating the frequencies of current and new cases, describing the presence of anemia and bone metabolism disorders. Methods: Thirty-five patients aged 7 to 19 years-old on hemodialysis (HD) or peritoneal dialysis (PD) were studied between June 2018 and April 2019. The frequencies of current and new cases were estimated based on the 0 to 19 years-old population of Amazonas, in the same period. Data were collected about the underlying cause and diagnosis of CKD, dialysis, and biochemical analysis. Results: The frequencies of current and new cases were 24 and 15 patients per million people of compatible age (pmpca), respectively. The causes of CKD were nephrotic syndrome (22.8%), nephritic syndrome (14.3%), and neurogenic bladder (14.3%); in 48.6%, the cause was unknown/not investigated. Ten patients underwent renal biopsy, seven with segmental and focal glomerulosclerosis. The majority (80%) were on HD, with an average kt/V of 1.4, and in 51.4% the vascular access was the double lumen catheter. Hypocalcemia was found in 82.8% of patients, hyperphosphatemia in 57.2%, vitamin D insufficiency or deficiency in 60%, and altered parathyroid hormone values in 48.6%. Hemoglobin was low in 80%, with absolute/functional iron deficiency in 28.6%. Conclusions: In children and adolescents of Amazonas, Brazil, we found 24 pmpca with stage-5 CKU currently in RRT and 16.3 pmpca per year of new cases requiring RRT. Most patients were adolescents on HD, half without a causal diagnosis of CKD, with a high frequency of anemia and bone metabolism disorder.

show abstract

Section: Methodsmentioning

confidence: 99%