Chondroblastic osteosarcoma of the mandible: case report

Oliveira, Loara Gabriela R.; Cunha, John Lennon Silva; Bezerra, Bruno Torres; Melo, Matheus Santos; Fonte, Juliana Batista Melo Da; Albuquerque, Ricardo Luiz Cavalcanti de

doi:10.5935/1676-2444.20180021

Cited by 4 publications

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“…(Figure 1) Extraoral facial swelling near right body of mandible was bony hard and slow growing. (Figure 2) Despite of striking differences both were painless which was contrary to previous reports from literature 4,5,6 .…”

Section: Case Reportcontrasting

confidence: 84%

Chondroblastic Osteosarcoma in Adolescent: Crucial Decision of Site of Biopsy to Avoid Diagnostic Adversity.

Dhiman

Mahajan

Jain

et al. 2023

Preprint

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Section: Case Reportcontrasting

confidence: 84%

Chondroblastic Osteosarcoma in Adolescent: Crucial Decision of Site of Biopsy to Avoid Diagnostic Adversity.

Dhiman

Mahajan

Jain

et al. 2023

Preprint

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“…In the center of the lobules, chondrocytes show severe atypia while the peripheral areas are more cellular, containing spindle cells that surround tumor osteoid deposits [ 6 , 15 ]. Thereby, the presence of a large amount of chondroid matrix makes the distinction between chondroblastic osteosarcoma and grade III chondrosarcoma difficult [ 18 ]. The identification of osteoid matrix deposits is the most determinant factor that leads to the diagnosis of chondroblastic osteosarcoma [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…The identification of osteoid matrix deposits is the most determinant factor that leads to the diagnosis of chondroblastic osteosarcoma [ 15 ]. However, in grade III chondrosarcoma, endochondral ossification can lead to the formation of metaplastic bone in the form of trabecular eosinophilic matrix within the cartilage lobules that may be misinterpreted as osteoid deposit, leading to the diagnosis of chondroblastic osteosarcoma [ 16 , 18 ]. In this case, the distinction between metaplastic bone and osteoid is the cornerstone of the differential diagnosis [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

A cartilage-forming tumor of the mandibular angle: a case report

et al. 2022

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Background Mandible can be the site of benign or malignant lesions of different origins, including odontogenic and non-odontogenic lesions. Cartilage-forming tumors have been rarely reported at this site. Chondrosarcoma is a rare malignant cartilage-producing neoplasm that is extremely rare in the mandible. The rarity of cartilage-forming tumor occurrence in the mandible can make diagnosis difficult for pathologists, as they do not expect this type of tumor at this anatomical site. Here we report a case of chondrosarcoma of mandibular angle. Case presentation A 70-year-old Moroccan male patient consulted a dentist for wisdom tooth pain. Wisdom tooth extraction was conducted. After 6 months, the patient reported the recurrence of pain associated with swelling in the mandibular area and paresthesia along the path of the mandibular nerve. A panoramic radiograph demonstrated a mixed radiolucent–opaque lesion involving the mandibular angle. Computed tomography showed a large osteolytic spontaneously hypointense and multilobulated lesion. A biopsy was done. Histopathological examination revealed sheets and irregular lobules of atypical cells presenting cartilaginous differentiation. Tumor cells showed severe nuclear atypia and were located within a hyaline cartilage matrix. Some foci of necrosis were noted. Osteoid deposits were not found. The patient was diagnosed with grade III chondrosarcoma and underwent a right segmental mandibulectomy with submandibular lymph node dissection. Macroscopically, the tumor was localized in the mandibular angle with extension in the mandibular body. Histopathology confirmed the previous diagnosis of grade III chondrosarcoma and did not show any lymph node metastasis. Conclusions Owing to many histological similarities, grade III chondrosarcoma must be distinguished from chondroblastic osteosarcoma and metastatic lesions. In addition, chondroblastic osteosarcoma of the jawbones has a worse prognosis than chondrosarcoma, making the distinction between these two malignant tumors the most important concern of the pathologist when dealing with a cartilage-forming tumor at this site. Surgery with wide excision margins remains the best therapeutic approach, while the role of radiotherapy is controversial. The management of mandibular chondrosarcoma requires a multidisciplinary approach involving maxillofacial surgeons, radiologists, pathologists, and oncologists.

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Chondroblastic osteosarcoma of the mandible: case report

Cited by 4 publications

References 0 publications

Chondroblastic Osteosarcoma in Adolescent: Crucial Decision of Site of Biopsy to Avoid Diagnostic Adversity.

Chondroblastic Osteosarcoma in Adolescent: Crucial Decision of Site of Biopsy to Avoid Diagnostic Adversity.

A cartilage-forming tumor of the mandibular angle: a case report

Prevalence and prognostic merit of paraesthesia in lower jaw osteosarcoma: A meta-analysis

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