2016
DOI: 10.5935/1676-2444.20160051
|View full text |Cite
|
Sign up to set email alerts
|

Report of a case of paroxysmal nocturnal hemoglobinuria (PNH) with complex evolution and liver transplant

Abstract: The history of muscle biopsy dates back to 1860, when Duchenne first performed a biopsy on a patient with symptoms of myopathy (1) . Since then, the basic and clinical science of muscle and muscle disease has gone through three stages of development: the classical period, the modern stage and the molecular era.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3

Citation Types

0
2
0
1

Year Published

2019
2019
2021
2021

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(3 citation statements)
references
References 0 publications
0
2
0
1
Order By: Relevance
“…PNH can occur at any age, but it is generally diagnosed between third and fifth decades. [2][3][4][5] Patients experience intravascular hemolysis, smooth muscle dystonia, renal failure, arterial and pulmonary hypertension, recurrent infectious diseases, and an increased risk of notably dreadful thrombotic complications. [6] The diagnosis of PNH is made by means of clinical findings and laboratory tests to confirm the degree of hemolysis (haptoglobin, lactate dehydrogenase, direct Coombs test, reticulocyte count and total bilirubin and bilirubin fraction) and deficiency of anchored proteins of the complement system (CD55, CD59, and FLAER) in granulocytes (CD15, CD33, and CD24) and monocytes (CD14 and CD64) by flow cytometry, the gold standard method.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…PNH can occur at any age, but it is generally diagnosed between third and fifth decades. [2][3][4][5] Patients experience intravascular hemolysis, smooth muscle dystonia, renal failure, arterial and pulmonary hypertension, recurrent infectious diseases, and an increased risk of notably dreadful thrombotic complications. [6] The diagnosis of PNH is made by means of clinical findings and laboratory tests to confirm the degree of hemolysis (haptoglobin, lactate dehydrogenase, direct Coombs test, reticulocyte count and total bilirubin and bilirubin fraction) and deficiency of anchored proteins of the complement system (CD55, CD59, and FLAER) in granulocytes (CD15, CD33, and CD24) and monocytes (CD14 and CD64) by flow cytometry, the gold standard method.…”
Section: Introductionmentioning
confidence: 99%
“…As regards sex, in Europe, PNH is more common in women, whereas in Asia it is more common in men. PNH can occur at any age, but it is generally diagnosed between third and fifth decades [2–5] . Patients experience intravascular hemolysis, smooth muscle dystonia, renal failure, arterial and pulmonary hypertension, recurrent infectious diseases, and an increased risk of notably dreadful thrombotic complications [6] …”
Section: Introductionmentioning
confidence: 99%
“…O gene PIG-A é responsável pela codificação de uma enzima crítica na formação da proteína âncora glicosil-fosfatidil-inositol (GPI), a qual realiza a fixação de múltiplas proteínas na membrana citoplasmática. A deficiência de GPI conduz a uma carência de proteínas reguladoras do SC ligada à superfície dos eritrócitos, tornando-os susceptíveis a hemólise intravascular mediada pelo sistema complemento (ARAUJO CJ, et al, 2002;PARKER C, et al, 2005;ALENCAR RCB et al, 2016).…”
Section: Introductionunclassified