Patient-level costs of central line-associated bloodstream infections caused by
            multidrug-resistant microorganisms in a public intensive care unit in Brazil: a
            retrospective cohort study

Júnior, Antonio Paulo Nassar; Bezerra, Isabella Lott; Malheiro, Daniel Tavares; Diaz, Maria Dolores Montoya; Schettino, Guilherme; Pereira, Adriano José

doi:10.5935/0103-507x.20220313-en

Cited by 1 publication

(1 citation statement)

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“…The economic burden of ICU onset BSI is sizeable. A recent a study of 66 patients admitted to a Brazilian ICU found that while patients with CA-BSI experience increased hospital costs when compared to patients without CA-BSI, this was not different among MDR vs. non-MDR bacteria [37].…”

Section: Outcome Treatment and Costmentioning

confidence: 94%

Central line associated and primary bloodstream infections

Stewart,

Laupland,

Tabah

2023

Current Opinion in Critical Care

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Purpose of review Primary and intravascular catheter-associated bloodstream infections (CA-BSIs) represent an important clinical entity in the intensive care unit (ICU) being associated with significant morbidity and mortality. The purpose of this review was to examine the recently published data on epidemiology and management of CA-BSI and other primary BSIs specifically within the context of the ICU. Recent findings In critically ill patients, the pooled prevalence of primary and CA-BSI from contemporary studies was 19.7–40.7% and 26.4–37.3% of all BSIs, respectively. Failure to achieve source control (i.e., removal of catheter in CA-BSI) is associated with higher mortality. Higher severity scores and durations of ICU stay and catheter insertion are well established risk factors for CA-BSI. The use of prevention bundles when inserting a central venous line is able to reduce CA-BSI incidence from 4 to 1.6 episodes per 1000 central venous catheter days. Differential time-to-positivity of paired blood cultures may assist in the diagnosis of CA-BSI. Summary Primary BSI is frequently observed in ICU cohorts and has a poor effect on outcome. Surveillance for BSI among patients admitted to ICUs is fundamental to inform healthcare service delivery, design preventive approaches, to track resistance, and detect emerging pathogens.

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Section: Outcome Treatment and Costmentioning

confidence: 94%