Clinical characteristics and predictors of mechanical ventilation in patients with COVID-19 hospitalized in Southern Brazil

Bastos, Gisele Alsina Nader; Azambuja, Aline Zimmermann de; Polanczyk, Carísi Anne; Gräf, Débora Dalmas; Zorzo, Isabelle Weschenfelder; Maccari, Juçara Gasparetto; Haygert, Lúcia Schnor; Nasi, Luiz Antônio; Gazzana, Marcelo Basso; Bessel, Marina; Pitrez, Paulo Márcio; Oliveira, Roselaine Pinheiro de; Scottá, Marcelo Comerlato

doi:10.5935/0103-507x.20200082

Cited by 21 publications

(15 citation statements)

References 23 publications

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“…The characteristics of our sample are consistent with other cohorts of patients hospitalized during the first wave of the COVID-19 pandemic in different countries. Therefore, the mean age of our sample (63.0) and the sex distribution (53.7% of men) are similar to previous studies such as the recently published Mediterranean cohort study [18], studies conducted in Italy [21] and Brazil [22] and other Spanish multicentre studies [23], although slightly different from other national reports [24]. For example, Carfi et al showed 56.5 mean age and 63% of men [20] and Garrigues et al showed 58 mean age and 63% of women [12].…”

Section: Characteristics Of the Cohortsupporting

confidence: 90%

Sequelae, persistent symptomatology and outcomes after COVID-19 hospitalization: the ANCOHVID multicentre 6-month follow-up study

Romero-Duarte

Rivera-Izquierdo

Alba

et al. 2021

BMC Med

115

103

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Background Long-term effects of COVID-19, also called Long COVID, affect more than 10% of patients. The most severe cases (i.e. those requiring hospitalization) present a higher frequency of sequelae, but detailed information on these effects is still lacking. The objective of this study is to identify and quantify the frequency and outcomes associated with the presence of sequelae or persistent symptomatology (SPS) during the 6 months after discharge for COVID-19. Methods Retrospective observational 6-month follow-up study conducted in four hospitals of Spain. A cohort of all 969 patients who were hospitalized with PCR-confirmed SARS-CoV-2 from March 1 to April 15, 2020, was included. We collected all the SPS during the 6 months after discharge reported by patients during follow-up from primary care records. Cluster analyses were performed to validate the measures. The main outcome measures were return to the Emergency Services, hospital readmission and post-discharge death. Surviving patients’ outcomes were collected through clinical histories and primary care reports. Multiple logistic regression models were applied. Results The 797 (82.2%) patients who survived constituted the sample followed, while the rest died from COVID-19. The mean age was 63.0 years, 53.7% of them were men and 509 (63.9%) reported some sequelae during the first 6 months after discharge. These sequelae were very diverse, but the most frequent were respiratory (42.0%), systemic (36.1%), neurological (20.8%), mental health (12.2%) and infectious (7.9%) SPS, with some differences by sex. Women presented higher frequencies of headache and mental health SPS, among others. A total of 160 (20.1%) patients returned to the Emergency Services, 35 (4.4%) required hospital readmission and 8 (1.0%) died during follow-up. The main factors independently associated with the return to Emergency Services were persistent fever, dermatological SPS, arrythmia or palpitations, thoracic pain and pneumonia. Conclusions COVID-19 cases requiring hospitalization during the first wave of the pandemic developed a significant range of mid- to long-term SPS. A detailed list of symptoms and outcomes is provided in this multicentre study. Identification of possible factors associated with these SPS could be useful to optimize preventive follow-up strategies in primary care for the coming months of the pandemic.

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Section: Characteristics Of the Cohortsupporting

confidence: 90%

Sequelae, persistent symptomatology and outcomes after COVID-19 hospitalization: the ANCOHVID multicentre 6-month follow-up study

Romero-Duarte

Rivera-Izquierdo

Alba

et al. 2021

BMC Med

115

103

View full text Add to dashboard Cite

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“…A similar pattern also manifested itself among the older patients, but less pronouncedly, possibly due to the prevalent accumulation of comorbidities among individuals in these strata. Our results confirmed the association of aging with the demand for healthcare resources and COVID-19-related deaths reported in different Brazilian states, ( Sousa et al, 2020 , Macedo et al, 2020 , Cobre et al, 2020 , Escosteguy et al, 2020 , Moura et al, 2020 , Leal et al, 2021 , Policarpo et al, 2021 , Bastos et al, 2020 ) in population restricted to a clinical condition or not, or even in national population studies, ( Santos et al, 2021 , de Souza et al, 2020 , Nascimento et al, 2020 , Marcolino et al, 2021 , Castro et al, 2021 ) but also reported in studies in Latin America, ( Escalera-Antezana et al, 2020 , Araujo et al, 2020 , Elizondo et al, 2021 , Galindo et al, 2021 , Yacobitti et al, 2021 , Ortiz-Prado et al, 2021 ) and in international cohorts ( Pepe et al, 2021 ). Overall, frailty and the high prevalence of comorbidities made the elderly more susceptible to severe infection by COVID-19.…”

Section: Discussionsupporting

confidence: 90%

Risk assessment and rationalization of health resource allocation: Lessons from the Brazilian COVID-19 cohort in 2020

Cattani

Santos

Castro-Alves

et al. 2022

Preventive Medicine Reports

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“…Despite the large number of studies published since the beginning of the pandemic, the knowledge of SARS-CoV-2 infection test accuracy is still evolving. As critical cases of COVID-19 were far more common in older adults and patients with comorbidities, most studies assessing the accuracy of diagnostic tests were performed in this population 7 , 8 , 9 , 10 .…”

Section: Introductionmentioning

confidence: 99%

Low performance of a SARS-CoV-2 point-of-care lateral flow immunoassay in symptomatic children during the pandemic

Scottá

David

Varela

et al. 2022

Jornal de Pediatria

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Objective To evaluate the accuracy of an antibody point-of-care lateral flow immunoassay (LFI - Wondfo Biotech Co., Guangzhou, China) in a pediatric population. Methods Children and adolescents (2 months to 18 years) with signs and symptoms suggestive of acute SARS-CoV-2 infection were prospectively investigated with nasopharyngeal RT-PCR and LFI at the emergency room. RT-PCR was performed at baseline, and LFI at the same time or scheduled for those with less than 7 days of the clinical picture. Overall accuracy, sensitivity and specificity were assessed, as well as according to the onset of symptoms (7-13 or ≥14 days) at the time of LFI test. Results In 175 children included, RT-PCR and LFI were positive in 51 (29.14%) and 36 (20.57%), respectively. The overall sensitivity, specificity, positive and negative predictive value was of 70.6% (95%CI 56.2-82.5), 96.8% (95%CI 91.9-99.1), 90.0% (95%CI 77.2-96.0), and 88.9% (95%CI 83.9-92.5), respectively. At 7-13 and ≥14 days after the onset of symptoms, sensitivity was 60.0% (95%CI 26.2-87.8) and 73.2% (95%CI 57.1-85.8) and specificity was 97.9% (95%CI 88.7-99.9) and 96.1% (95%CI 89.0-99.2), respectively. Conclusion Despite its high specificity, in the present study, the sensitivity of LFI in children was lower (around 70%) than most reports in adults. In acute care settings, although a positive result is informative, a negative LFI test cannot rule out COVID-19 in children.

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Clinical characteristics and predictors of mechanical ventilation in patients with COVID-19 hospitalized in Southern Brazil

Cited by 21 publications

References 23 publications

Sequelae, persistent symptomatology and outcomes after COVID-19 hospitalization: the ANCOHVID multicentre 6-month follow-up study

Sequelae, persistent symptomatology and outcomes after COVID-19 hospitalization: the ANCOHVID multicentre 6-month follow-up study

Risk assessment and rationalization of health resource allocation: Lessons from the Brazilian COVID-19 cohort in 2020

Low performance of a SARS-CoV-2 point-of-care lateral flow immunoassay in symptomatic children during the pandemic

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