From the International Pediatric Sepsis Conference 2005 to the Sepsis-3 Consensus

Souza, Daniela Carla de; Brandão, Marcelo Barciela; Piva, Jefferson Pedro

doi:10.5935/0103-507x.20180005

Cited by 12 publications

(9 citation statements)

References 38 publications

(68 reference statements)

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“…Although improvements in neonatal care have decreased the impact of early-onset sepsis in term infants, preterm babies remain at high risk for both early-onset and late-onset sepsis and their sequelae. According to the guidelines of the International Pediatric Sepsis Consensus Conference 104 , neonatal sepsis is defined as a clinical syndrome characterized by the presence of both infection and systemic inflammatory response syndrome (SIRS) and can cause severe neurological complications due to brain infection, as well as secondary hypoxemia resulting from septic shock, pulmonary hypertension and severe lung disease.…”

Section: Clinical Utility In Newbornsmentioning

confidence: 99%

Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care

et al. 2019

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Melatonin, more commonly known as the sleep hormone, is mainly secreted by the pineal gland in dark conditions and regulates the circadian rhythm of the organism. Its intrinsic properties, including high cell permeability, the ability to easily cross both the blood–brain and placenta barriers, and its role as an endogenous reservoir of free radical scavengers (with indirect extra activities), confer it beneficial uses as an adjuvant in the biomedical field. Melatonin can exert its effects by acting through specific cellular receptors on the plasma membrane, similar to other hormones, or through receptor-independent mechanisms that involve complex molecular cross talk with other players. There is increasing evidence regarding the extraordinary beneficial effects of melatonin, also via exogenous administration. Here, we summarize molecular pathways in which melatonin is considered a master regulator, with attention to cell death and inflammation mechanisms from basic, translational and clinical points of view in the context of newborn care.

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Section: Clinical Utility In Newbornsmentioning

confidence: 99%

Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care

et al. 2019

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“…Eighty children with sepsis-related encephalopathy, admitted to the PICU of the Children's Hospital Affiliated to Zhengzhou University from January 2015 to January 2018, were enrolled. Inclusion criteria: patients who met the diagnostic criteria for sepsis in children established by the International Children's Sepsis Conference (7). Patients with sepsis-associated encephalopathy were selected according to their symptoms.…”

Section: Methodsmentioning

confidence: 99%

Changes of rScO2 and ScvO2 in childrenwith sepsis‑related encephalopathywith different prognoses and clinical features

et al. 2019

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Clinical features of sepsis-associated encephalopathy in children with different prognoses were analyzed and the changes of regional cerebral oxygen saturation (rScO 2 ) and central venous oxygen saturation (ScvO 2 ) were measured. Eighty children with sepsis-related encephalopathy, admitted to the Pediatric Intensive Care Unit (PICU) of the Children's Hospital Affiliated to Zhengzhou University, were enrolled in this study and post-intensive care syndrome (PICS) scoring was performed within 24 h after admission. Patients were separated into groups according to the score results and treatment outcomes. Clinical features, functional tests, imaging examinations, PICS scores, and modified Glasgow Coma Scale (GCS) scores were compared among children with varying severities and prognoses. The changes of rScO 2 and ScvO 2 at different time-points among children with different prognoses were measured and compared. According to PICS scores, there were 8 non-critically ill children, 42 critically ill children, and 30 extremely critically ill children. Fifty-two children survived, and the survival rate was 65%. Comparison of the clinical characteristics of children with different conditions showed that deep coma, generalized seizure, severe electroencephalogram (EEG) abnormalities, and the survival of children were significantly associated with the severity of disease (P<0.05). At the same time, compared to the survivors group, the rates of generalized seizures and severe EEG abnormalities were significantly increased in the deceased children group, while the PICS and GCS scores were significantly decreased (P<0.05). rScO 2 values in the deceased group were lower than those in the survival group at different time-points, but the differences were not significant (P>0.05). On the contrary, ScvO 2 values were significantly higher in the deceased group than those in the survivors group (P<0.05). The lower the PICS and GCS scores in children with sepsis-related encephalopathy, the more serious the condition, and the more likely to develop disturbance of consciousness, epileptic seizures, and abnormal EEG changes. Whereas, changes of ScvO 2 are closely related to prognosis.

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“…It is also interesting that the majority of patients (77%) were diagnosed with concomitant diseases, among which the most common were respiratory disorders. The most common foci of infection were the respiratory system (40%) and blood flow (19%) [1], [13], [14], [15].…”

Section: Epidemiology Of Sepsismentioning

confidence: 99%

Modern Diagnostics of Sepsis and Septic Shock in Children

Bulatova

Maltabarova

Zhumabayev

et al. 2020

Open Access Maced J Med Sci

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Sepsis is still one of the leading causes of child mortality worldwide, despite advances in its diagnosis and treatment. Difficulties in recognizing the transition of a localized infectious-inflammatory process to a generalized one lead to a belated diagnosis and the beginning of therapy. Meanwhile, the earlier treatment is started, the higher the patients’ chances of life. Early diagnosis of sepsis, which corresponds to modern ideas about this condition, is one of the main tasks for both scientists and practitioners. The aim of this review is to study modern recommendations for the diagnosis of sepsis and septic shock in children. The article reflects the epidemiology, etiological features, modern definitions, and methods of diagnosis of pediatric sepsis.

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From the International Pediatric Sepsis Conference 2005 to the Sepsis-3 Consensus

Cited by 12 publications

References 38 publications

Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care

Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care

Changes of rScO2 and ScvO2 in childrenwith sepsis‑related encephalopathywith different prognoses and clinical features

Modern Diagnostics of Sepsis and Septic Shock in Children

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